Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Monica J Killen"'
Autor:
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancre
Externí odkaz:
https://doaj.org/article/1dd7417190fc4a1586f84ed7e4b76935
Autor:
Farah Alimagham, Tanya Hutter, Núria Marco-García, Stephen R. Elliott, Dan Hutter, Anna Huefner, Peter J. Hutchinson, Keri L. H. Carpenter, Susan Giorgi-Coll, Monica J Killen, Victoria H. Highland, Agnieszka P. Zakrzewska, Emma Gould
Publikováno v:
Analytical Chemistry
Funder: Wellcome Trust
The brains of patients suffering from traumatic brain-injury (TBI) undergo dynamic chemical changes in the days following the initial trauma. Accurate and timely monitoring of these changes is of paramount importance for i
The brains of patients suffering from traumatic brain-injury (TBI) undergo dynamic chemical changes in the days following the initial trauma. Accurate and timely monitoring of these changes is of paramount importance for i
Autor:
Matthew G Stovell, Ari Ercole, Ivan Timofeev, T. Adrian Carpenter, Monica J Killen, Ibrahim Jalloh, Peter J. Hutchinson, Keri L. H. Carpenter, David K. Menon, Mathew R. Guilfoyle, Aftab Alam, Tamara Tajsic, Adel Helmy, Abdelhakim Khellaf, Duncan J. Howe, Eric Peter Thelin, Michael P. Murphy, Nuria Marco Garcia
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects impaired energy metabolism. Raised LPR correlates with poor outcome and mortality following TBI. We prospectively recruited patients with TBI requiring neur
Autor:
Robert F. Shearer, Paul Timpson, Pauline Mélénec, Kendelle J. Murphy, Mark Pinese, David R. Croucher, Aurélie Cazet, Arne S.A. Adam, Anaiis Zaratzian, C. Elizabeth Caldon, Yingxiao Wang, Jody J. Haigh, Richard P. Harvey, Alice Boulghourjian, Gonzalo del Monte-Nieto, Claire Vennin, Marina Pajic, Owen J. Sansom, Andrew M. Da Silva, David Herrmann, James R.W. Conway, Sean C. Warren, Monica J. Killen, Jennifer P. Morton, Astrid Magenau, Max Nobis
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Cell Reports
Cell Reports
Summary Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancrea
A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
Autor:
Max Nobis, Tatyana Chtanova, Marina Pajic, Douglas Strathdee, Peter W. Gunning, Stacey N. Walters, Peter I. Croucher, Juliane P. Schwarz, Edna C. Hardeman, Julian M. W. Quinn, Kurt I. Anderson, Alice Boulghourjian, Agata Mrowinska, James R.W. Conway, Owen J. Sansom, Christopher J. Ormandy, Nadine Reischmann, David Herrmann, Paul Timpson, Monica J. Killen, Heidi C.E. Welch, Lei Zhang, Jennifer P. Morton, Michael S. Samuel, Andrius Masedunskas, Claire Vennin, Paul A. Baldock, Shereen Kadir, Jacqueline Bailey, Anna-Karin E. Johnsson, Richard P. Harvey, Andrew M. K. Law, Wilfred Leung, Ewan J. McGhee, Morghan C. Lucas, Gonzalo del Monte-Nieto, Anaiis Zaratzian, Herbert Herzog, Astrid Magenau, David A. Stevenson, Shane T. Grey, Sean C. Warren, David Gallego-Ortega
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 274-288 (2017)
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to govern mechanosensing, growth, and motility of cells, while its deregulation is associated with disease development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5ae14f85f6dbaec756cfb97ddafd72
Introduction: Traumatic Brain Injury (TBI) is a leading cause of death and disability in young people, affecting 69 million people annually, worldwide. The initial trauma disrupts brain homeostasis resulting in metabolic dysfunction and an inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8dee02bc9c948b8c0c3dcd629f6e92