Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Monica Hirsch-Kauffmann"'
Publikováno v:
bchm. 389:1327-1332
Fanconi anemia is a fatal, hereditary chromosome instability syndrome of early childhood with progressive pancytopenia and cancer-proneness. Hypersensitivity to alkylating agents points to DNA repair inefficiency. Excess reactive oxygen intermediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f07463ea17cbc9dc6d11b50bc88acd7
https://doi.org/10.1515/bc.2008.151
https://doi.org/10.1515/bc.2008.151
Publikováno v:
Cell Biology International. 29:1032-1037
Mutations in the lamin A gene have been shown, among other defects, to give rise to Hutchinson-Gilford progeria syndrome (HGPS) and to atypical Werner syndrome (WS), both of which are progeroid disorders. Here, we have investigated well-characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbfb516015eadc40d478f2e98ab9b4b5
https://doi.org/10.1016/j.cellbi.2005.10.011
https://doi.org/10.1016/j.cellbi.2005.10.011
Autor:
Annemarie Poustka, Maria Kontou, Rainer Wittig, Manfred Schweiger, Rainer Will, Monica Hirsch-Kauffmann, Caroline Adelfalk
Publikováno v:
Oncogene. 23:2146-2152
Cancer cells have high levels of thioredoxin (Trx) and of glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Cells from patients with the cancer-prone disease Fanconi anemia (FA) exhibit reduced Trx levels. We found the activity of GAPDH to correlate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389c2039afdbe454c6d65c071fe6e9a5
https://doi.org/10.1038/sj.onc.1207334
https://doi.org/10.1038/sj.onc.1207334
Autor:
Manfred Schweiger, Caroline Adelfalk, Maria Kontou, Monica Hirsch-Kauffmann, Maria Helena Ramirez
Publikováno v:
Biological Chemistry. 384:169-174
Fanconi anemia (FA) is a hereditary disease of unknown pathogenic mechanisms, although mutations in seven different genes can be causative. Six of these genes have been cloned and sequenced. Only slight homology to the DNA of any other known gene has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270e5e544c903cea790fbeb4783b1697
https://doi.org/10.1515/bc.2003.018
https://doi.org/10.1515/bc.2003.018
Autor:
Maria Helena Ramirez, Manfred Schweiger, Monica Hirsch-Kauffmann, Caroline Adelfalk, Maria Kontou, Werner Ruppitsch
Publikováno v:
Oncogene. 21:2406-2412
The cause of the molecular defect of Fanconi anemia (FA) remains unknown. Cells from patients with FA exert an elevated spontaneous chromosomal instability which is further triggered by mitomycin C. The induced lability is reduced by overexpression o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96c62f155925e9849e4b2675ba7640f
https://doi.org/10.1038/sj.onc.1205299
https://doi.org/10.1038/sj.onc.1205299
Autor:
Manfred Schweiger, Thomas von Zglinicki, Caroline Adelfalk, Violeta Serra, Monica Hirsch-Kauffmann, Mario Lorenz
Publikováno v:
FEBS Letters. 506:22-26
Fanconi anemia (FA) is a fatal inherited disease displaying chromosomal instability, disturbances in oxygen metabolism and a high burden of intracellular radical oxygen species. Oxygen radicals can damage DNA including telomeric regions. Insufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326fe0e82bc0b52f624d2a9f8cadf328
https://doi.org/10.1016/s0014-5793(01)02869-1
https://doi.org/10.1016/s0014-5793(01)02869-1
Autor:
Christoph Weise, Monica Hirsch-Kauffmann, Felicitas Lerner, Mathias Ziegler, Thomas Specht, Shiao Li Oei, Klaus Hennig, Manfred Schweiger, Marc Niere
Publikováno v:
FEBS Letters. 492:95-100
Nicotinamide mononucleotide adenylyl transferase (NMNAT) is an essential enzyme in all organisms, because it catalyzes a key step of NAD synthesis. However, little is known about the structure and regulation of this enzyme. In this study we establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68782612d9426bad0591169c84c29fc
https://doi.org/10.1016/s0014-5793(01)02180-9
https://doi.org/10.1016/s0014-5793(01)02180-9
Autor:
Manfred Schweiger, Monica Hirsch-Kauffmann, Dagmar Lackinger, Werner Ruppitsch, Maria Helena Ramirez
Publikováno v:
FEBS Letters. 440:103-106
Fanconi anemia (FA) is an autosomal recessive disorder characterized by skeletal abnormalities, pancytopenia and a marked predisposition to cancer. FA cells exhibit chromosomal instability and hypersensitivity towards oxygen and cross-linking agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a511999f437e306915267c5c160e08e
https://doi.org/10.1016/s0014-5793(98)01442-2
https://doi.org/10.1016/s0014-5793(98)01442-2
Regulation of the human poly(ADP-ribosyl) transferase promoter via alternative DNA racket structures
Autor:
Herbert Herzog, Monica Hirsch-Kauffmann, C. Menardi, Manfred Schweiger, Bernhard Auer, Shiao Li Oei, Rainer Schneider
Publikováno v:
Biochimie. 77:480-485
Human nuclear poly(ADP-ribosyl) transferase (ADPRT) protein content in cells suggests that ADPRT expression is stringently controlled. Analysis of the 3 kb promoter sequence, which is required for high level expression, revealed an extraordinary arch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad4d3c4edc6aab58ee871385068ebfb
https://doi.org/10.1016/0300-9084(96)88164-8
https://doi.org/10.1016/0300-9084(96)88164-8
Autor:
Monica Hirsch-Kauffmann, Shiao Li Oei, Herbert Herzog, Rainer Schneider, Manfred Schweiger, Bernhard Auer
Publikováno v:
Molecular and Cellular Biochemistry. 138:99-104
Human nuclear poly(ADP-ribosyl)transferase (ADPRT) modifies proteins with branched ADP-ribose-polymers. Various proteins, including ADPRT itself, serve as acceptors for polyADP-ribose. Target proteins include those controlling basic cellular processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a966ddcaa04bc61dea91f11fbf2af3df
https://doi.org/10.1007/bf00928449
https://doi.org/10.1007/bf00928449