Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Monica Hecht"'
Publikováno v:
British Journal of Haematology. 138:446-458
Formation of osteolytic lesions is a key pathophysiological feature in multiple myeloma and results from the interaction of myeloma cells with the bone marrow microenvironment. Matrix metalloproteinases (MMPs) and plasmin may be involved in bone dest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93455de81bc76f554c04d6cb47960dd3
https://doi.org/10.1111/j.1365-2141.2007.06665.x
https://doi.org/10.1111/j.1365-2141.2007.06665.x
Autor:
Claudia Fleissner, Maren Mieth, Monica Hecht, Jan Sterz, Christian Jakob, Orhan Sezer, Martin Kaiser, Holger Krebbel, R A Manz, I von Metzler, Lorenz Kleeberg, Ulrike Heider
Publikováno v:
Leukemia. 21:2025-2034
In multiple myeloma, the overexpression of receptor activator of nuclear factor kappa B (NF-kappaB) ligand (RANKL) leads to the induction of NF-kappaB and activator protein-1 (AP-1)-related osteoclast activation and enhanced bone resorption. The purp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e83071be02fcf8adb163e56ec2806b
https://doi.org/10.1038/sj.leu.2404806
https://doi.org/10.1038/sj.leu.2404806
Autor:
Orhan Sezer, Ulrike Heider, Ivana Zavrski, Christian Jakob, Christian Müller, Martin Kaiser, Monica Hecht, Claudia Fleissner, Carsten-Oliver Schulz
Publikováno v:
European journal of haematology. 77(3)
Objectives: Myeloma bone disease is a result of excessive osteoclast activation and impaired osteoblast function. Recent in vitro studies suggested that proteasome inhibitors might increase osteoblast function. Methods: We analyzed serum markers of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488ea827780adbe411b2aed212cee910
https://pubmed.ncbi.nlm.nih.gov/16923110
https://pubmed.ncbi.nlm.nih.gov/16923110
Publikováno v:
Current medicinal chemistry. 12(26)
In human solid cancer, the lymph node status is the most important prognostic indicator for the clinical outcome of patients. Follow-up data has shown that about 80% of metastasis follows an orderly pattern of progression via the lymphatic network wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851b766a6fad63ccd904e398c8ff2e6a
https://pubmed.ncbi.nlm.nih.gov/16375699
https://pubmed.ncbi.nlm.nih.gov/16375699
Autor:
Monica Hecht, Ivana Zavrski, Claudia Fleissner, Martin Kaiser, Christian Jakob, Ulrike Heider, Orhan Sezer
Publikováno v:
European journal of cancer (Oxford, England : 1990). 42(11)
Bone disease, a hallmark of multiple myeloma occurs in the majority of the patients, is associated with bone pain, fractures, hypercalcemia and has major impacts on quality of life. Myeloma is characterized by a unique form of bone disease with osteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f87dca7879969aeab38b99f62f1da77
https://pubmed.ncbi.nlm.nih.gov/16765040
https://pubmed.ncbi.nlm.nih.gov/16765040
Publikováno v:
Carcinogenesis. 26(12)
Neuroblastoma is the most frequent extracranial solid malignancy of childhood with a high mortality in advanced tumour stages. The hallmark of neuroblastoma is its clinical and biological heterogeneity. The molecular mechanisms leading to favourable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f685bb93fc9af02b5092bb2c60389ff
https://pubmed.ncbi.nlm.nih.gov/16051641
https://pubmed.ncbi.nlm.nih.gov/16051641
Publikováno v:
Biochemical and biophysical research communications. 330(3)
Neuroblastoma is the most frequent extracranial solid tumour of childhood. Despite multiple clinical efforts, clinical outcome has remained poor. Neuroblastoma is considered to be radiosensitive, but some clinical studies including the German trial N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01271202f0a581462816d289165480a7
https://pubmed.ncbi.nlm.nih.gov/15809092
https://pubmed.ncbi.nlm.nih.gov/15809092
Publikováno v:
Cancer research. 64(17)
Neuroblastoma is the most frequent solid childhood malignancy. Despite aggressive therapy, mortality is high due to rapid tumor progression to advanced stages. The molecules and mechanisms underlying poor prognosis are not well understood. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0165cba9493396901c04e74abf52990
https://pubmed.ncbi.nlm.nih.gov/15342394
https://pubmed.ncbi.nlm.nih.gov/15342394
Autor:
A. Elmaouhoub, Maria Papoutsi, Joerg Wilting, Giuliano Ramadori, C. S. von Kaisenberg, Bodo Christ, Monica Hecht, Bernhard Saile, Lothar Schweigerer, Jozsef Dudas, Stanislav I. Tomarev
Publikováno v:
Anatomy and Embryology. 208
Prox1 is a transcription factor with two highly conserved domains, a homeobox and a prospero domain. It has been shown that Prox1 knock-out mice die during early embryonic stages and display a rudimentary liver. We have studied the expression of Prox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee36e958caab217c5259c7056fc2d041
https://doi.org/10.1007/s00429-004-0403-4
https://doi.org/10.1007/s00429-004-0403-4
Publikováno v:
Klinische Pädiatrie. 216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2e7bb627b599d5b223142dc7af50e25
https://doi.org/10.1055/s-2004-828572
https://doi.org/10.1055/s-2004-828572