Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Monica Guma"'
Autor:
Kwanghoon Lee, Marina Banuls-Mirete, Alecio F. Lombardi, Alexander I.B. Posis, Eric Y. Chang, Nancy E. Lane, Monica Guma
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)
Abstract Objectives Adipose tissue has been associated with knee osteoarthritis (KOA) pathogenesis, but the longitudinal changes in adipose tissue with KOA progression have not been carefully evaluated. This study aimed to determine if longitudinal c
Externí odkaz:
https://doaj.org/article/ef9f80152e8140819338a8102365dfad
Autor:
Stefan Siebert, Georg Schett, Siba P. Raychaudhuri, Monica Guma, Warner Chen, Sheng Gao, Soumya D. Chakravarty, Frederic Lavie, Proton Rahman
Publikováno v:
Therapeutic Advances in Musculoskeletal Disease, Vol 16 (2024)
Background: Guselkumab (human monoclonal antibody) selectively inhibits the interleukin (IL)-23p19 subunit. Objectives: Assess the longer-term pharmacodynamic effects of guselkumab and explore associations between such effects and clinical responses
Externí odkaz:
https://doaj.org/article/5fabba911e814e3b861bb0ca24ddd72f
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent progression of OA. In this sense,
Externí odkaz:
https://doaj.org/article/b12025d97c9742b480683588472500b1
Autor:
Shanzay Ahmed, Christopher B. Mahony, Alyssa Torres, Jessica Murillo-Saich, Samuel Kemble, Martha Cedeno, Peter John, Attya Bhatti, Adam P. Croft, Monica Guma
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition of these pathways by phytobiological compound c28MS ha
Externí odkaz:
https://doaj.org/article/af32fe3ff392445c91651d974582a84f
Autor:
Alyssa Torres, Sarah Kang, Christopher B. Mahony, Martha Cedeño, Patricia G. Oliveira, Marta Fernandez-Bustamante, Samuel Kemble, Teresina Laragione, Percio S. Gulko, Adam P. Croft, Elsa Sanchez-Lopez, Shigeki Miyamoto, Monica Guma
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundGlucose metabolism, specifically, hexokinase 2 (HK2), has a critical role in rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) phenotype. HK2 localizes not only in the cytosol but also in the mitochondria, where it protects mitoch
Externí odkaz:
https://doaj.org/article/56bc636062be4eb9b0e55981ccd93727
Autor:
Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan, Robert Terkeltaub
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Objective Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inhibitor urate-lowering
Externí odkaz:
https://doaj.org/article/2e001f3b06a94a069b0f462242812c21
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Metabolomic studies show that rheumatoid arthritis (RA) is associated with metabolic disruption. Metabolic changes in fibroblast-like synoviocytes (FLS) likely contribute to FLS abnormal response and strongly contribute to joint destruction. These ch
Externí odkaz:
https://doaj.org/article/13f918f75d264016b96dd93d232b105c
Autor:
Jessica D. Murillo-Saich, Roxana Coras, Robert Meyer, Cristina Llorente, Nancy E. Lane, Monica Guma
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100295- (2022)
Objective: Inflammatory responses are associated with changes in tissue metabolism. Prior studies find altered metabolomic profiles in both the synovial fluid (SF) and serum of osteoarthritis subjects. Our study determined the metabolomic profile of
Externí odkaz:
https://doaj.org/article/897185ef11bc41f4955f6bc01943ee38
Autor:
Roxana Coras, Arthur Kavanaugh, Angela Kluzniak, Dustina Holt, Amy Weilgosz, Armando Aaron, Oswald Quehenberger, Christopher Ritchlin, Monica Guma
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Oxylipins are biological lipids that have been implicated in inflammation. We previously found that certain oxylipins correlated with clinical manifestations in psoriatic arthritis (PsA) patients. Here, we compare oxylipin profile
Externí odkaz:
https://doaj.org/article/070e850d2dcc42cd8ed7ed2d8b367286
Autor:
Roxana Coras, Cameron Martino, Julia M. Gauglitz, Francesca Cedola, Anupriya Tripathi, Alan K. Jarmusch, Maram Alharthi, Marta Fernandez‐Bustamante, Meritxell Agustin‐Perez, Abha Singh, Soo‐In Choi, Tania Rivera, Katherine Nguyen, Tatyana Shekhtman, Tiffany Holt, Susan Lee, Shahrokh Golshan, Pieter C. Dorrestein, Rob Knight, Monica Guma
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/060d7b5c223449169399b643b94f466f