Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Monica Florio"'
Autor:
Babak Basiri, Fang Xie, Bin Wu, Sara C. Humphreys, Julie M. Lade, Mai B. Thayer, Pam Yamaguchi, Monica Florio, Brooke M. Rock
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 725-736 (2020)
There has been a renewed interest in therapeutic small interfering RNAs (siRNAs) over the past few years. This is particularly the result of successful and efficient delivery of N-acetylgalactosamine (GalNAc)-conjugated siRNAs to the liver. In genera
Externí odkaz:
https://doaj.org/article/31612adf3dbc4f6d9346df118252c413
Autor:
Monica Florio, Kannan Gunasekaran, Marina Stolina, Xiaodong Li, Ling Liu, Barbara Tipton, Hossein Salimi-Moosavi, Franklin J. Asuncion, Chaoyang Li, Banghua Sun, Hong Lin Tan, Li Zhang, Chun-Ya Han, Ryan Case, Amy N. Duguay, Mario Grisanti, Jennitte Stevens, James K. Pretorius, Efrain Pacheco, Heidi Jones, Qing Chen, Brian D. Soriano, Jie Wen, Brenda Heron, Frederick W. Jacobsen, Emil Brisan, William G. Richards, Hua Zhu Ke, Michael S. Ominsky
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bi
Externí odkaz:
https://doaj.org/article/5b80b8c1d296447f878d119b9b8140cb
Autor:
Monica Florio, Paul J. Kostenuik, Marina Stolina, Franklin J. Asuncion, Mario Grisanti, Hua Zhu Ke, Michael S. Ominsky
Publikováno v:
Journal of Bone and Joint Surgery.
Autor:
Michael J. Koren, Patrick Maurice Moriarty, Seth J. Baum, Joel Neutel, Martha Hernandez-Illas, Howard S. Weintraub, Monica Florio, Helina Kassahun, Stacey Melquist, Tracy Varrieur, Saptarsi M. Haldar, Winnie Sohn, Huei Wang, Mary Elliott-Davey, Brooke M. Rock, Tao Pei, Oliver Homann, Jennifer Hellawell, Gerald F. Watts
Publikováno v:
Nature Medicine. 28:96-103
Compelling evidence supports a causal role for lipoprotein(a) (Lp(a)) in cardiovascular disease. No pharmacotherapies directly targeting Lp(a) are currently available for clinical use. Here we report the discovery and development of olpasiran, a firs
Autor:
Lei Liu, Jason Long, Ingrid C. Rulifson, Brad Herberich, Miki Hardy, Oliver Homann, Monica Florio, Mei-Chu Lo, Jerry Ryan Holder, Shivani Singh, Hui Dou, Michael Ollmann, Elissa Swearingen, Danielle Pruitt, Kelvin K. C. Sham, Bin Wu, Justin K. Murray, Artem Shkumatov
Publikováno v:
Nucleic Acid Therapeutics. 31:324-340
Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA...
Autor:
Ignacio Anegon, Mélanie Lambert, Séverine Remy, Marc Humbert, Fabrice Antigny, Florent Soubrier, Olaf Mercier, Elie Fadel, Barbara Girerd, David Montani, Bahgat Soilih, Juliette Bignard, Sophie Nadaud, Grégoire Manaud, Frédéric Perros, Stjin Verleden, Monica Florio, Florence Lecerf, Banghua Sun, Gérald Simmoneau, Olivier Claude
Publikováno v:
Pulmonary hypertension.
Introduction: Pulmonary veno-occlusive disease (PVOD) is an orphan fatal disease. The identification of biallelic inactivating mutations of EIF2AK4 (encoding GCN2) as the major genetic cause of PVOD has clarified the nosology of the disease. On the o
Autor:
Séverine Remy, Juliette Bignard, Audrey Courboulin, Gérald Simonneau, Maria-Rosa Ghigna, Marc Humbert, Ignacio Anegon, Mélanie Lambert, Fabrice Antigny, Monica Florio, Esther J. Nossent, Banghua Sun, Harm Jan Bogaard, Elie Fadel, Aurélie Hautefort, Anton Vonk Noordegraaf, Angèle Boet, Barbara Girerd, Maria-Candida Vinhas, Grégoire Manaud, Sophie Nadaud, Frédéric Perros, Stijn E. Verleden, Olivier Claude, Sébastien J. Dumas, Florent Soubrier, Peter Dorfmüller, Benoit Ranchoux, Florence Lecerf, Olaf Mercier, David Montani, Katrien Grünberg
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
American Journal of Respiratory Cell and Molecular Biology, 2020, Epub ahead of print. ⟨10.1165/rcmb.2019-0015OC⟩
American Journal of Respiratory Cell and Molecular Biology, 63(1), 118-131. American Thoracic Society
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2020, Epub ahead of print. ⟨10.1165/rcmb.2019-0015OC⟩
Manaud, G, Nossent, E J, Lambert, M, Ghigna, M R, Boet, A, Vinhas, M C, Ranchoux, B, Dumas, S J, Courboulin, A, Girerd, B, Soubrier, F, Bignard, J, Claude, O, Lecerf, F, Hautefort, A, Florio, M, Sun, B, Nadaud, S, Verleden, S E, Remy, S, Anegon, I, Bogaard, H J, Mercier, O, Fadel, E, Simonneau, G, Noordegraaf, A V, Grunberg, K, Humbert, M, Montani, D, Dorfmuller, P, Antigny, F & Perros, F 2020, ' Comparison of human and experimental pulmonary veno-occlusive disease ', American Journal of Respiratory Cell and Molecular Biology, vol. 63, no. 1, pp. 118-131 . https://doi.org/10.1165/rcmb.2019-0015OC
American journal of respiratory cell and molecular biology
American Journal of Respiratory Cell and Molecular Biology, 2020, Epub ahead of print. ⟨10.1165/rcmb.2019-0015OC⟩
American Journal of Respiratory Cell and Molecular Biology, 63(1), 118-131. American Thoracic Society
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society, 2020, Epub ahead of print. ⟨10.1165/rcmb.2019-0015OC⟩
Manaud, G, Nossent, E J, Lambert, M, Ghigna, M R, Boet, A, Vinhas, M C, Ranchoux, B, Dumas, S J, Courboulin, A, Girerd, B, Soubrier, F, Bignard, J, Claude, O, Lecerf, F, Hautefort, A, Florio, M, Sun, B, Nadaud, S, Verleden, S E, Remy, S, Anegon, I, Bogaard, H J, Mercier, O, Fadel, E, Simonneau, G, Noordegraaf, A V, Grunberg, K, Humbert, M, Montani, D, Dorfmuller, P, Antigny, F & Perros, F 2020, ' Comparison of human and experimental pulmonary veno-occlusive disease ', American Journal of Respiratory Cell and Molecular Biology, vol. 63, no. 1, pp. 118-131 . https://doi.org/10.1165/rcmb.2019-0015OC
American journal of respiratory cell and molecular biology
Pulmonary veno-occlusive disease (PVOD) occurs in humans either as a heritable form (hPVOD) due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2) or as a sporadic form in older age (sPVOD). The chemotherapeutic agent mitomycin C (MMC) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6a44aa70dbdb40b0e9cfded999f5f8
https://lirias.kuleuven.be/handle/123456789/653108
https://lirias.kuleuven.be/handle/123456789/653108
Autor:
Pam Yamaguchi, Sara C. Humphreys, Mai B. Thayer, Bin Wu, Julie M. Lade, Fang Xie, Babak Basiri, Monica Florio, Brooke M. Rock
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 725-736 (2020)
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 725-736 (2020)
There has been a renewed interest in therapeutic small interfering RNAs (siRNAs) over the past few years. This is particularly the result of successful and efficient delivery of N-acetylgalactosamine (GalNAc)-conjugated siRNAs to the liver. In genera
Autor:
Werner Seeger, Friedrich Grimminger, Baktybek Kojonazarov, Rajkumar Savai, Norbert Weissmann, Ralph T. Schermuly, Soni Savai Pullamsetti, Jan Sun, Swati Dabral, Lavinia Maegel, Hossein Ardeschir Ghofrani, Monica Florio, Danny Jonigk, Xia Tian
Publikováno v:
European Respiratory Journal. 48:1137-1149
Pulmonary arterial hypertension (PAH) is characterised by excessive pulmonary vascular remodelling involving deregulated proliferation of cells in intima, media as well as adventitia. Pulmonary arterial endothelial cell (PAEC) hyperproliferation and
Autor:
J. Bignard, Sophie Nadaud, Florent Soubrier, Séverine Remy, Grégoire Manaud, V. Stijn, Marc Humbert, Ignacio Anegon, B. Abdoulkarim, Fabrice Antigny, Monica Florio, Maria-Candida Vinhas, O. Claude, Frédéric Perros, David Montani, Olaf Mercier, S. Banghua
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 12:217
Introduction Pulmonary veno-occlusive disease (PVOD) occurs in humans as heritable form due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2), or as a sporadic form. The pathobiology of this orphan fatal disease is currently unknown. How