Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Monica F. Tolosa"'
Autor:
Xiaolin He, Monica F. Tolosa, Tianzhou Zhang, Santosh Kumar Goru, Luisa Ulloa Severino, Paraish S. Misra, Caitríona M. McEvoy, Lauren Caldwell, Stephen G. Szeto, Feng Gao, Xiaolan Chen, Cassandra Atin, Victoria Ki, Noah Vukosa, Catherine Hu, Johnny Zhang, Christopher Yip, Adriana Krizova, Jeffrey L. Wrana, Darren A. Yuen
Publikováno v:
JCI Insight, Vol 7, Iss 4 (2022)
Fibrotic diseases account for nearly half of all deaths in the developed world. Despite its importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two mechanosensitive transcription cofactors YAP and TAZ have emerged as imp
Externí odkaz:
https://doaj.org/article/4fe66df753c24722aff314855974d52f
Autor:
Tianzhou Zhang, Xiaolin He, Lauren Caldwell, Santosh Kumar Goru, Luisa Ulloa Severino, Monica F. Tolosa, Paraish S. Misra, Caitríona M. McEvoy, Tania Christova, Yong Liu, Cassandra Atin, Johnny Zhang, Catherine Hu, Noah Vukosa, Xiaolan Chen, Adriana Krizova, Anish Kirpalani, Alex Gregorieff, Ruoyu Ni, Kin Chan, Mandeep K. Gill, Liliana Attisano, Jeffrey L. Wrana, Darren A. Yuen
Publikováno v:
Science Translational Medicine. 14
Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming growth factor–β (TGF-β)–driven scarring is an importa
Autor:
Moustafa Abdalla, Claudia C. dos Santos, Laurette Geldenhuys, Sri N. Batchu, Darren A. Yuen, Monica F. Tolosa, Mohamed Abdalla, Andrew Advani, Ferhan S. Siddiqi
Publikováno v:
Current research in translational medicine. 68(4)
Background Current uncertainties about the similarity between human diseases and their experimental models are hampering the development of new therapies. This is especially the case for diabetic kidney disease (DKD), the most common cause of end-sta
Autor:
Monica F. Tolosa, Lisa A. Robinson, Xiaolin He, Santosh Kumar Goru, Paraish S. Misra, Xiaolan Chen, Tianzhou Zhang, Darren A. Yuen
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Our understanding of diabetic kidney disease pathogenesis has been hampered by the lack of easily generated pre-clinical animal models that faithfully recapitulate critical features of human disease. While most standard animal models develop manifest
Autor:
Stellar Boo, Krystale De Freitas, Rohan John, Mingliang Lu, Ahmad M. Sidiqi, Qinghong Dan, Janne Folke Bialik, Xiaolin He, Darren A. Yuen, Andrew Advani, Stephen G. Szeto, Masahiro Narimatsu, Jeffrey L. Wrana, Syamantak Majumder, Lauren Chan, Boris Hinz, Andras Kapus, Monica F. Tolosa
Publikováno v:
Journal of the American Society of Nephrology. 27:3117-3128
Like many organs, the kidney stiffens after injury, a process that is increasingly recognized as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are related mechanosensory