Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Monica Einav"'
Autor:
Ekaterina Eremenko, Anastasia Golova, Daniel Stein, Monica Einav, Ekaterina Khrameeva, Debra Toiber
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100643- (2021)
Summary: The organization of chromatin structure plays a crucial role in gene expression, DNA replication, and repair. Chromatin alterations influence gene expression, and modifications could be associated with genomic instability in the cells during
Externí odkaz:
https://doaj.org/article/c92e1ebf26644423be94ea7e8551b60e
Autor:
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Publikováno v:
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://doaj.org/article/8ec54c204be64101928f8e9ebb75bef6
Autor:
Shai Kaluski, Miguel Portillo, Antoine Besnard, Daniel Stein, Monica Einav, Lei Zhong, Uwe Ueberham, Thomas Arendt, Raul Mostoslavsky, Amar Sahay, Debra Toiber
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3052-3062 (2017)
The histone deacetylase SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. Furthermore, SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. Here, we report that bra
Externí odkaz:
https://doaj.org/article/2d6330c2933042aeba10c132fa2db6f9
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-12 (2015)
Abstract Background The parasite composition of wild host individuals often impacts their behavior and physiology, and the transmission dynamics of pathogenic species thereby determines disease risk in natural communities. Yet, the determinants of pa
Externí odkaz:
https://doaj.org/article/57f6a4aad26c4d63a235d248424f4a6b
Autor:
Daniel Stein, Zeev Slobodnik, Benjamin Tam, Monica Einav, Barak Akabayov, Shimon Berstein, Debra Toiber
Publikováno v:
Aging Cell. 21
Loss of proteostasis can occur due to mutations, the formation of aggregates, or general deficiency in the correct translation and folding of proteins. These phenomena are commonly observed in pathologies, but most significantly, loss of proteostasis
Autor:
Alfredo Garcia Venzor, Debra Toiber, Ekaterina Khrameeva, Anastasia Golova, Daniel Stein, Monica Einav, Shai Kaluski, Amir Mizrahi, Adam Saretzky, Zeev Slobodnik
Publikováno v:
Aging
Aging (Albany NY)
Aging (Albany NY)
Brain-specific SIRT6-KO mice present increased DNA damage, learning impairments, and neurodegenerative phenotypes, placing SIRT6 as a key protein in preventing neurodegeneration. In the aging brain, SIRT6 levels/activity decline, which is accentuated
Publikováno v:
Cell Reports
Autor:
Ekaterina Eremenko, Lior Onn, Shai Kaluski, Thomas Arendt, Debra Toiber, Martina K. Brückner, Monica Einav, Uwe Ueberham, Miguel Portillo, Daniel Stein, Zeev Slobodnik
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee3d9894f875469e06ca354859dabb1
https://doi.org/10.1101/2020.09.01.276782
https://doi.org/10.1101/2020.09.01.276782
Autor:
Zeev Slobodnik, Daniel Stein, Miguel Portillo, Gal Cleitman, Ido Shirat, Fabian Erdel, Barak Akabayov, Stefan Ilic, Lior Onn, Debra Toiber, Shai Kaluski, Monica Einav
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Autor:
Zeev Slobodnik, Debra Toiber, Daniel Stein, Lior Onn, Gal Cleitman, Monica Einav, Miguel Portillo, Barak Akabayov, Fabian Erdel, Stefan Ilic, Shai Kaluski, Ido Shirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0fc6ba377eed6bc1ac4e7de6254a0e2
https://doi.org/10.7554/elife.51636.sa2
https://doi.org/10.7554/elife.51636.sa2