Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Monica Driscol"'
Autor:
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll
Publikováno v:
eLife, Vol 13 (2024)
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as e
Externí odkaz:
https://doaj.org/article/c7cece9d67354cd59c1a7a7f1b5a4181
Autor:
Francis R. G. Amrit, Nikki Naim, Ramesh Ratnappan, Julia Loose, Carter Mason, Laura Steenberge, Brooke T. McClendon, Guoqiang Wang, Monica Driscoll, Judith L. Yanowitz, Arjumand Ghazi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Resistance to stress is often associated with increased longevity. Using the model organism C. elegans the authors here show that TCER-1 enhances lifespan while at the same time increasing sensitivity to a number of biotic and abiotic stressors.
Externí odkaz:
https://doaj.org/article/854db20aa1e64954adf08377385046bf
Autor:
Haelim Jeong, Jun Young Park, Ji-Hyun Lee, Ja-Hyun Baik, Chae-Yeon Kim, Jin-Young Cho, Monica Driscoll, Young-Ki Paik
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2393 (2022)
When animals are faced with food depletion, food search-associated locomotion is crucial for their survival. Although food search-associated locomotion is known to be regulated by dopamine, it has yet to investigate the potential molecular mechanisms
Externí odkaz:
https://doaj.org/article/eedb3c6942ae40fab10fbd3dcbf529c2
Autor:
Jessica H. Hartman, Latasha L. Smith, Kacy L. Gordon, Ricardo Laranjeiro, Monica Driscoll, David R. Sherwood, Joel N. Meyer
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Abstract Exercise and caloric restriction improve health, including reducing risk of cardiovascular disease, neurological disease, and cancer. However, molecular mechanisms underlying these protections are poorly understood, partly due to the cost an
Externí odkaz:
https://doaj.org/article/72d3f1ab341c44bab535ac51b4bbcded
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-7 (2018)
Abstract Caenorhabditis elegans neurons have recently been found to throw out cellular debris for remote degradation and/or storage, adding an “extracellular garbage elimination” option to known intracellular protein and organelle degradation pat
Externí odkaz:
https://doaj.org/article/30eec02dc5424365823aaa6f8d7dd382
Publikováno v:
BMC Biology, Vol 15, Iss 1, Pp 1-17 (2017)
Abstract Background Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedentary and the aging pop
Externí odkaz:
https://doaj.org/article/e7cb0c14d61e40dea61122862eec8848
Autor:
Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face
Externí odkaz:
https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
Autor:
Christophe Restif, Carolina Ibáñez-Ventoso, Mehul M Vora, Suzhen Guo, Dimitris Metaxas, Monica Driscoll
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 7, p e1003702 (2014)
In the effort to define genes and specific neuronal circuits that control behavior and plasticity, the capacity for high-precision automated analysis of behavior is essential. We report on comprehensive computer vision software for analysis of swimmi
Externí odkaz:
https://doaj.org/article/b7ea62d0e4ad4e0bac5d97e36960f219
Autor:
Mehul Vora, Mitalie Shah, Silvana Ostafi, Brian Onken, Jian Xue, Julie Zhouli Ni, Sam Gu, Monica Driscoll
Publikováno v:
PLoS Genetics, Vol 9, Iss 8, p e1003737 (2013)
Caloric/dietary restriction (CR/DR) can promote longevity and protect against age-associated disease across species. The molecular mechanisms coordinating food intake with health-promoting metabolism are thus of significant medical interest. We repor
Externí odkaz:
https://doaj.org/article/681881f70e31431a88d94fc2ab2b1037
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e24 (2008)
In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy, the large-scale recycling of cytoplasmic macromolecules and organ
Externí odkaz:
https://doaj.org/article/a6fa573a97ca435d8cee88cb9e1048da