Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Monica Diez"'
Autor:
Pablo García-González, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcón-Martín, Inés Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, María Teresa Periñán, Ignacio Alvarez, Monica Diez-Fairen, Raul Nuñez Llaves, Claudia Olivé Roig, Guillermo Garcia-Ribas, Manuel Menéndez-González, Carmen Martínez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macías, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodríguez-Rodríguez, Jose Luís Royo, Victoria Álvarez, Pau Pastor, Gerard Piñol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sánchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tàrraga, Alfredo Ramirez, Mercé Boada, Agustín Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 898 (2023)
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at the mo
Externí odkaz:
https://doaj.org/article/c8c4eaad08a8470cafc3738e4c60364f
Autor:
Laura Ibanez, Jorge A. Bahena, Chengran Yang, Umber Dube, Fabiana H. G. Farias, John P. Budde, Kristy Bergmann, Carol Brenner-Webster, John C. Morris, Richard J. Perrin, Nigel J. Cairns, John O’Donnell, Ignacio Álvarez, Monica Diez-Fairen, Miquel Aguilar, Rebecca Miller, Albert A. Davis, Pau Pastor, Paul Kotzbauer, Meghan C. Campbell, Joel S. Perlmutter, Herve Rhinn, Oscar Harari, Carlos Cruchaga, Bruno A. Benitez
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Alpha-synuclein is the main protein component of Lewy bodies, the pathological hallmark of Parkinson’s disease. However, genetic modifiers of cerebrospinal fluid (CSF) alpha-synuclein levels remain unknown. The use of CSF levels of amyloid
Externí odkaz:
https://doaj.org/article/2077762f363c437892ba2473c6937bd7
Autor:
Rita Guerreiro, Valentina Escott-Price, Dena G. Hernandez, Celia Kun-Rodrigues, Owen A. Ross, Tatiana Orme, Joao Luis Neto, Susana Carmona, Nadia Dehghani, John D. Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, Juan C. Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimon, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St. George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda M. Halliday, John Hardy, John Q. Trojanowski, Dennis W. Dickson, Andrew Singleton, David J. Stone, Jose Bras
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 492-501 (2019)
Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established
Externí odkaz:
https://doaj.org/article/8a8a606f7f4c49d690647ef64ba97f82
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104782- (2020)
ABSTRACT: A substantial proportion of risk for Parkinson's disease (PD) is driven by genetics. Progress in understanding the genetic basis of PD has been significant. So far, highly-penetrant rare genetic alterations in SNCA, LRRK2, VPS35, PRKN, PINK
Externí odkaz:
https://doaj.org/article/3b60f047456b44f781a3f9660c916131
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8100 (2021)
In recent decades, genetic research has nominated promising pathways and biological insights contributing to the etiological landscape of parkinsonism-related dystonias and atypical parkinsonism-related syndromes. Several disease-causing mutations an
Externí odkaz:
https://doaj.org/article/c3ffd2f81dfb4a778ce1e48340fbbddf
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7332 (2020)
Parkinson’s disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic
Externí odkaz:
https://doaj.org/article/5bc9616bc3ce4a68ab3dab964eadac42
Autor:
Laia Lidón, Laura Urrea, Franc Llorens, Vanessa Gil, Ignacio Alvarez, Monica Diez-Fairen, Miguel Aguilar, Pau Pastor, Inga Zerr, Daniel Alcolea, Alberto Lleó, Enric Vidal, Rosalina Gavín, Isidre Ferrer, Jose Antonio Del Rio
Publikováno v:
Cells, Vol 9, Iss 5, p 1252 (2020)
Reelin is an extracellular glycoprotein that modulates neuronal function and synaptic plasticity in the adult brain. Decreased levels of Reelin activity have been postulated as a key factor during neurodegeneration in Alzheimer’s disease (AD) and i
Externí odkaz:
https://doaj.org/article/f1cc810480224948ae90f211bd73ce37
Autor:
Laura Ibanez, Umber Dube, Albert A. Davis, Maria V. Fernandez, John Budde, Breanna Cooper, Monica Diez-Fairen, Sara Ortega-Cubero, Pau Pastor, Joel S. Perlmutter, Carlos Cruchaga, Bruno A. Benitez
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Background: The prevalence of dementia in Parkinson disease (PD) increases dramatically with advancing age, approaching 80% in patients who survive 20 years with the disease. Increasing evidence suggests clinical, pathological and genetic overlap bet
Externí odkaz:
https://doaj.org/article/38ad410771764cc98017f4fcc283ee0f
Autor:
Alex Rodrigo Espinoza Giacomozzi, Alexander Parajeles Vindas, Ariovaldo Alberto da Silva Junior, Carlos Alberto Bordini, Carlos Federico Buonanotte, Celia Aparecida de Paula Roesler, Claudio Manoel Brito, Cristina Perez, Deusvenir de Souza Carvalho, Djacir Dantas Pereira de Macedo, Elcio Juliato Piovesan, Elder Machado Sarmento, Eliana Meire Melhado, Fabiola Dach Eckeli, Fernando Kowacs, Fidel Sobrino, Getulio Dare Rabello, Grisel Rada, Jano Alves de Souza, Juana Rosa Casanovas, Juan Carlos Duran, Leandro Cotoni Calia, Luis Roberto Partida Medina, Luiz Paulo de Queiroz, Marcelo Cedrinho Ciciarelli, Marcelo Moraes Valenca, Maria Cusicanqui, Maria Karina Velez Jimenez, Maria Tereza Goycochea, Mario Fernando Prieto Peres, Mario Victor Fuentealba Sandoval, Maurice Borges Vincent, Michel Volcy Gomes, Monica Diez, Nayeska Aranaga, Nelson Barrientos, Pedro Andre Kowacs, Pedro Ferreira Moreira Filho
Publikováno v:
Arquivos de Neuro-Psiquiatria, Vol 71, Iss 7, Pp 478-486 (2013)
Chronic migraine is a condition with significant prevalence all around the world and high socioeconomic impact, and its handling has been challenging neurologists. Developments for understanding its mechanisms and associated conditions, as well as th
Externí odkaz:
https://doaj.org/article/40063349cd204be980e6aaa48d014d36
Autor:
Rajesh Chandramohanadas, YongKeun Park, Lena Lui, Ang Li, David Quinn, Kingsley Liew, Monica Diez-Silva, Yongjin Sung, Ming Dao, Chwee Teck Lim, Peter Rainer Preiser, Subra Suresh
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20869 (2011)
Upon infection and development within human erythrocytes, P. falciparum induces alterations to the infected RBC morphology and bio-mechanical properties to eventually rupture the host cells through parasitic and host derived proteases of cysteine and
Externí odkaz:
https://doaj.org/article/c80e62bb8ec94890847210c1a3952ce4