Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Monica Devi Prakash"'
Autor:
Matthias Regner, Katrina Louise Scarff, Monica Devi Prakash, Carolina R. Melo-Silva, Aulikki Koskinen, Arno Müllbacher, Alexandra Rizzitelli, Jennii Luu, Matthew Mangan, Catherina H. Bird, Phillip I. Bird
Publikováno v:
Immunology & Cell Biology. 95:884-894
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc01edb63dbf69bf11e623810448c815
https://doi.org/10.1038/icb.2017.59
https://doi.org/10.1038/icb.2017.59
Autor:
Brendan R Wilding, Caitlin Williams, Connie Fung, Phillip I. Bird, Evelyn Yip, Robert J. Bryson-Richardson, Heather Verkade, Aminah Giousoh, Monica Devi Prakash
Publikováno v:
Biological chemistryReferences. 400(12)
In human α1-antitrypsin deficiency, homozygous carriers of the Z (E324K) mutation in the gene SERPINA1 have insufficient circulating α1-antitrypsin and are predisposed to emphysema. Misfolding and accumulation of the mutant protein in hepatocytes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219c071671265c78c8518d3b9690f2b0
https://pubmed.ncbi.nlm.nih.gov/31091192
https://pubmed.ncbi.nlm.nih.gov/31091192
Autor:
Paulus Mrass, Stephen J. Turner, Bosco K. Ho, Marcia A. Munoz, Matthew R. Olson, Philip L. Tong, Monica Devi Prakash, Aulikki Koskinen, Phillip I. Bird, Rohit Jain, Oded Kleifeld, Wolfgang Weninger, Matthias Regner
Publikováno v:
Immunity. 41:960-972
SummaryGranzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e485919d8d92afe1d02865775c763230
https://doi.org/10.1016/j.immuni.2014.11.012
https://doi.org/10.1016/j.immuni.2014.11.012
Publikováno v:
The American Journal of Pathology. 183:49-59
A homozygous mutation of SERPINB6, a gene encoding an intracellular protease inhibitor, has recently been associated with post-lingual, autosomal-recessive, nonsyndromic hearing loss in humans (DFNB91). Herein, we describe the physiological changes u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53664ba383df5f67f857bc8194ad5cc
https://doi.org/10.1016/j.ajpath.2013.03.009
https://doi.org/10.1016/j.ajpath.2013.03.009
Autor:
Monica Devi Prakash, Jessica L. Vieusseux, Jennii Luu, Susan R. Berkowicz, James C. Whisstock, John T. Price, Phillip I. Bird, Sonia S.Y. Teoh, Carlos J. Rosado, Ruby H. P. Law, Catherina H. Bird
Publikováno v:
Nature Communications
Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9deaab4a91916cc55f76f0f9493b851
http://europepmc.org/articles/PMC3905777
http://europepmc.org/articles/PMC3905777
Autor:
Melinda E. Christensen, Nigel J. Waterhouse, Matthew Mangan, Monica Devi Prakash, Karin A Sedelies, Phillip I. Bird, Catherina H. Bird, Ian S. Harper, Mark J. Smyth
Publikováno v:
Cell death and differentiation. 21(6)
Cytotoxic lymphocytes (CLs) contain lysosome-related organelles (LROs) that perform the normal degradative functions of the lysosome, in addition to storage and release of powerful cytotoxins employed to kill virally infected or abnormal cells. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7250fb79f20636470b8b9ae753428723
https://pubmed.ncbi.nlm.nih.gov/24488096
https://pubmed.ncbi.nlm.nih.gov/24488096
Publikováno v:
Monash University
Granzyme B (GrB) plays a well-established intracellular role in cytotoxic lymphocyte (CL)-mediated killing of abnormal cells; however, emerging evidence suggests that it participates in extracellular matrix remodeling and target cell destruction thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3d4adfe15c7fa758a53e836ec44fa7
https://research.monash.edu/en/publications/30174b1a-48fc-4e32-bbee-5487f6a31803
https://research.monash.edu/en/publications/30174b1a-48fc-4e32-bbee-5487f6a31803
