Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Monica Cacho Izquierdo"'
Autor:
Monica Cacho-Izquierdo, Marissa Lindman, Joël Lelièvre, Ruben Gonzalez Del Rio, Martin Gengenbacher, Véronique Dartois, Fátima Ortega, Uday S. Ganapathy, Thomas Dick, David Barros-Aguirre
Publikováno v:
Antimicrobial Agents and Chemotherapy
Global infections by nontuberculous mycobacteria (NTM) are steadily rising. New drugs are needed to treat NTM infections, but the NTM drug pipeline remains poorly populated and focused on repurposing or reformulating approved antibiotics.
Global
Global
Autor:
David Barros Aguirre, Lluis Ballell, Sarah M. Batt, Gurdyal S. Besra, John D. McKinney, Laura Vela-Glez Del Peral, Mike Rees, Bernadette Mouzon, Robert J. Young, Christopher D. Stubbs, Esther Pérez-Herrán, Julia Castro Pichel, Argyrides Argyrou, Jonathan P. Hutchinson, Neeraj Dhar, Monica Cacho Izquierdo
Publikováno v:
ACS Infectious Diseases. 1:615-626
We have targeted the Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose oxidase (Mt-DprE1) for potential chemotherapeutic intervention of tuberculosis. A multicopy suppression strategy that overexpressed Mt-DprE1 in M. bovis BCG was used to
Autor:
Robert H. Bates, Alfonso Mendoza, Joaquín Rullas, Joël Lelièvre, Chun Wa Chung, Ruth Casanueva, Sudagar S. Gurcha, Maria Santos Martinez-Martinez, Patrick J. Moynihan, Margarete Neu, Nicholas Cammack, Gurdyal S. Besra, Nicholas J. Loman, Jonathan A. G. Cox, Katherine A. Abrahams, Paul Homes, Marcus Bantscheff, Anthony Shillings, Gerard Drewes, Elena Jimenez-Navarro, Lluis Ballell, Matthew Axtman, Carolyn Selenski, Argyrides Argyrou, Monica Cacho Izquierdo, Iñigo Angulo-Barturen, Laurent Kremer, María José Rebollo-López, David Barros, Sonja Ghidelli-Disse
Publikováno v:
Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies sever
Autor:
Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inh
Externí odkaz:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e