Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Monica C. Gestal"'
Publikováno v:
mSphere, Vol 9, Iss 7 (2024)
ABSTRACT Host-microbe biology (HMB) stands on the cusp of redefinition, challenging conventional paradigms to instead embrace a more holistic understanding of the microbial sciences. The American Society for Microbiology (ASM) Council on Microbial Sc
Externí odkaz:
https://doaj.org/article/7b0284c0f5374de79289af69556b0117
Autor:
Nicholas J. First, Katelyn M. Parrish, Amparo Martínez-Pérez, África González-Fernández, Sushma Bharrhan, Matthew Woolard, James B. McLachlan, Rona S. Scott, Jian Wang, Monica C. Gestal
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113294- (2023)
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting
Externí odkaz:
https://doaj.org/article/1873108fec1342a0bbb5576abc0ed691
Autor:
José E. Villacís, Hugo G. Castelán-Sánchez, Jorge Rojas-Vargas, Ulises E. Rodríguez-Cruz, Viviana Albán, Jorge A. Reyes, Pablo M. Meza-Rodríguez, Sonia Dávila-Ramos, Fernando Villavicencio, Margarita Galarza, Monica C. Gestal
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
PurposeThe purpose of this study was to highlight the clinical and molecular features of 13 Raoultella ornithinolytica strains isolated from clinical environments in Ecuador, and to perform comparative genomics with previously published genomes of Ra
Externí odkaz:
https://doaj.org/article/87fa3d3a8d0b46e58f8673a648482aa1
Autor:
Nicholas J. First, Jose Pedreira-Lopez, Manuel R. F. San-Silvestre, Katelyn M. Parrish, Xiao-Hong Lu, Monica C. Gestal
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionBordetella are respiratory pathogens comprised of three classical Bordetella species: B. pertussis, B. parapertussis, and B. bronchiseptica. With recent surges in Bordetella spp. cases and antibiotics becoming less effective to combat inf
Externí odkaz:
https://doaj.org/article/3ede5c1a80774cbb95aefd9b643a2ba9
Autor:
Illiassou Hamidou Soumana, Bodo Linz, Kalyan K. Dewan, Demba Sarr, Monica C. Gestal, Laura K. Howard, Amanda D. Caulfield, Balázs Rada, Eric T. Harvill
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 8, Pp 2107-2116 (2021)
Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonizati
Externí odkaz:
https://doaj.org/article/52a1e2134579466bb858aae3afc08231
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
When bacteria sense cues from the host environment, stress responses are activated. Two component systems, sigma factors, small RNAs, ppGpp stringent response, and chaperones start coordinate the expression of virulence factors or immunomodulators to
Externí odkaz:
https://doaj.org/article/aadef8f738d84d99b3454e9d612be8ab
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Acute pathogens such as Bordetella pertussis can cause severe disease but are ultimately cleared by the immune response. This has led to the accepted paradigm that convalescent immunity is optimal and therefore broadly accepted as the “gol
Externí odkaz:
https://doaj.org/article/2d1d5cca2eaf4b079fdd3afe638a8a25
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Well-adapted pathogens have evolved to survive the many challenges of a robust immune response. Defending against all host antimicrobials simultaneously would be exceedingly difficult, if not impossible, so many co-evolved organisms utilize immunomod
Externí odkaz:
https://doaj.org/article/4fb81d48269a4c4089d42f003ea2e9bc
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8004 (2021)
Eosinophils are granulocytes primarily associated with TH2 responses to parasites or immune hyper-reactive states, such as asthma, allergies, or eosinophilic esophagitis. However, it does not make sense from an evolutionary standpoint to maintain a c
Externí odkaz:
https://doaj.org/article/c9fdf28525ce475e9ae2eed3a6804b4e
Publikováno v:
Microorganisms, Vol 8, Iss 12, p 1925 (2020)
Neutrophils and eosinophils are granulocytes that have very distinct functions. Neutrophils are first responders to external threats, and they use different mechanisms to control pathogens. Phagocytosis, reactive oxygen species, and neutrophil extrac
Externí odkaz:
https://doaj.org/article/4bf71a4b83f04579be1abb3c44f3f1d5