Výsledky vyhledávání - "Monica Bisbocci"

Akademický článek

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

Autor: Giacomo Paonessa, Giulia Siciliano, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)

High-throughput screening of 120,000 compounds followed by counter-screening and validation assays reveals candidate antimalarial drugs that kill Plasmodium falciparum sexual and asexual blood stages blocking parasite transmission through mosquito.

Externí odkaz: https://doaj.org/article/59fe7c35684348d7a872e3a5b86d2bef

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Akademický článek

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models

Autor: Valentina Fodale, Roberta Pintauro, Manuel Daldin, Roberta Altobelli, Maria Carolina Spiezia, Monica Bisbocci, Douglas Macdonald, Alberto Bresciani

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Abstract Huntington’s disease (HD) is a monogenetic neurodegenerative disorder that is caused by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete understanding of the molecular mechanisms

Externí odkaz: https://doaj.org/article/f0f9716e3bb54bde98e7f84e35b5a6f0

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Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome

Autor: Sergio Altamura, Antonio Baldini, Monica Bisbocci, Gabriella Lania, Vincenza Colonna, Alberto Bresciani, Alessandra Francone

Publikováno v: Scopus-Elsevier
Human Molecular Genetics
Human molecular genetics
(2017). doi:10.1093/hmg/ddx353
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddx353/rivista:Human molecular genetics (Print)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume
25 (2016): 4369–4375. doi:10.1093/hmg/ddw267
info:cnr-pdr/source/autori:Lania G, Bresciani A, Bisbocci M, Francone A, Colonna V, Altamura S, Baldini A./titolo:Vitamin B12 ameliorates the phenotype of a mouse model of DiGeorge syndrome./doi:10.1093%2Fhmg%2Fddw267/rivista:Human molecular genetics (Print)/anno:2016/pagina_da:4369/pagina_a:4375/intervallo_pagine:4369–4375/volume:25

Pathological conditions caused by reduced dosage of a gene, such as gene haploinsufficiency, can potentially be reverted by enhancing the expression of the functional allele. In practice, low specificity of therapeutic agents, or their toxicity reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65403d77703fedaac64046b8d33dc720
http://hdl.handle.net/11588/643539

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Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase

Autor: Michael Rowley, Sergio Altamura, Ian Stansfield, Giovanni Migliaccio, Licia Tomei, Alessandra Ceccacci, Laura Orsatti, Laura Pacini, Raffaele De Francesco, Nadia Gennari, Linda Bartholomew, Monica Bisbocci, Steven Harper, Antonino Biroccio, Frank Narjes, Ilario Incitti

Publikováno v: Journal of Virology. 77:13225-13231

The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is the catalytic subunit of the viral RNA amplification machinery and is an appealing target for the development of new therapeutic agents against HCV infection. Nonnucleoside inhibitors bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6633dcd14c2e4cd9d742de8b746bdd4e
https://doi.org/10.1128/jvi.77.24.13225-13231.2003

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Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)

Autor: Carsten Schultz-Fademrecht, Raffaele Ingenito, Jesus Maria Ontoria Ontoria, Carlo Toniatti, Monica Bisbocci, Michael Rowley, Philip Jones, Caterina Torrisi

Publikováno v: Bioorganicmedicinal chemistry letters. 20(2)

A novel hexahydrobenzonaphthyridinone PARP-1 pharmacophore is reported, subsequent SAR exploration around this scaffold led to selective PARP-1 inhibitors with low nanomolar enzyme potency, displaying good cellular activity and promising rat PK prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdc65b84669ed63b04c21dcab993125
https://pubmed.ncbi.nlm.nih.gov/20015648

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Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides

Autor: Linda Bartholomew, Monica Bisbocci, Michele Bosserman, Ilario Incitti, Sergio Altamura, Steven S. Carroll, David B. Olsen, Antonella Cellucci, Raffaele De Francesco, Licia Tomei, Uwe Koch, Giovanni Migliaccio, Carolyn Bailey, Laura Orsatti, Eleonora Forte

Publikováno v: Journal of virology. 78(2)

The RNA-dependent RNA polymerase of hepatitis C virus (HCV) is necessary for the replication of viral RNA and thus represents an attractive target for drug development. Several structural classes of nonnucleoside inhibitors (NNIs) of HCV RNA polymera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9419e38eae5cc3d86c5092fa78cd44bc
https://pubmed.ncbi.nlm.nih.gov/14694125

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