Chimeric Antigen by the Fusion of SARS-CoV-2 Receptor Binding Domain with the Extracellular Domain of Human CD154: A Promising Improved Vaccine Candidate

Autor: Ileanet Ávalos, Thailin Lao, Elsa María Rodríguez, Yasser Zamora, Alianet Rodríguez, Ailyn Ramón, Gilda Lemos, Ania Cabrales, Monica Bequet-Romero, Dionne Casillas, Ivan Andújar, Luis Ariel Espinosa, Luis Javier González, Yanitza Alvarez, Yamila Carpio, Mario Pablo Estrada

Publikováno v: Vaccines, Vol 10, Iss 6, p 897 (2022)

COVID-19 is a respiratory viral disease caused by a new coronavirus called SARS-CoV-2. This disease has spread rapidly worldwide with a high rate of morbidity and mortality. The receptor-binding domain (RBD) of protein spike (S) mediates the attachme

Externí odkaz: https://doaj.org/article/0e5e344f03334568b68b67f412e3b629

A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice

Autor: Laura Lazo, Monica Bequet-Romero, Gilda Lemos, Alexis Musacchio, Ania Cabrales, Andy J. Bruno, Luis Ariel Espinosa, Markku Saloheimo, Marika Vitikainen, Amalia Hernández, Mark Emalfarb, Ronen Tchelet, Edith Suzarte, Gerardo Guillén

Publikováno v: Lazo, L, Bequet-Romero, M, Lemos, G, Musacchio, A, Cabrales, A, Bruno, A J, Ariel Espinosa, L, Saloheimo, M, Vitikainen, M, Hernández, A, Emalfarb, M, Tchelet, R, Suzarte, E & Guillén, G 2022, ' A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice ', Vaccine, vol. 40, no. 8, pp. 1162-1169 . https://doi.org/10.1016/j.vaccine.2022.01.007
Vaccine

Since the beginning of the COVID-19 pandemic, the development of effective vaccines against this pathogen has been a priority for the scientific community. Several strategies have been developed including vaccines based on recombinant viral protein f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b4676512e1c3ec90c66b344e1ed72
https://cris.vtt.fi/en/publications/4fad051f-5c73-4ba6-bf06-b46a09dfb115

Nasalferon, a new nasal formulation of IFNα2b, modulates cellular and molecular elements associated with an antiviral response in mucosa and blood

Autor: Dania Vázquez-Blomquist, PhD, Mónica Bequet-Romero, PhD, Yssel Mendoza-Marí, PhD, Gilda Lemos, MSc, Iris Valdés, PhD, Camila Canaán-Haden Ayala, Isabel Gonzáles Moya, Ricardo Martínez Rosales, Giselle Freyre Corrales, Gerardo Guillén-Nieto, PhD

Publikováno v: Clinical Immunology Communications, Vol 2, Iss , Pp 39-45 (2022)

We conducted an experimental protocol with a nasal recombinant IFNα-2b formulation (Nasalferon) in 12 healthy volunteers who received 1 MIU per nostril twice a day, three consecutive days, and studied the induction of biomarkers related to antiviral

Externí odkaz: https://doaj.org/article/69e507cf31c44ef7a982bbeb3e996e9c

Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program

Autor: Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Yenima Martín Bauta, Katty-Hind Selman-Housein Bernal, Ana Victoria de la Torre Santos, Mariela Pérez de la Iglesia, Lian Trimiño Lorenzo, Team of Investigators of Compassionate use Program, Marta Ayala Avila

Publikováno v: BMC Immunology, Vol 21, Iss 1, Pp 1-17 (2020)

Abstract Background CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterially-derived adjuvant VSSP. CIGB-247 has been already evaluated in two phase I clinic

Externí odkaz: https://doaj.org/article/83a311ff8965457cb22be1b5e3513a13

Efectos sistémicos del tratamiento intralesional con factor de crecimiento epidérmico (Heberprot-P) en pacientes con úlceras de pie diabético

Autor: Ariana García Ojalvo, Jorge Berlanga Acosta, Yssel Mendoza Marí, Maday Fernández Mayola, Mónica Béquet Romero, Calixto Valdés Pérez, William Savigne Gutiérrez, Alain Figueroa Martínez, Ileydis Iglesias Marichal, Eduardo Álvarez Seijas, Amirelia Fabelo Martínez, Gerardo Guillén Nieto

Publikováno v: Anales de la Academia de Ciencias de Cuba, Vol 12, Iss 1 (2022)

Introducción. La infiltración intralesional con factor de crecimiento epidérmico (EGF) ha emergido como alternativa terapéutica para la cicatrización de las úlceras de pie diabético (UPD). Los objetivos de esta investigación fueron: determina

Externí odkaz: https://doaj.org/article/4e2b89f51ef54edd8da8bc4d126c32c2