Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Monica B. Kirby"'
Autor:
Brian M. Petersen, Monica B. Kirby, Karson M. Chrispens, Olivia M. Irvin, Isabell K. Strawn, Cyrus M. Haas, Alexis M. Walker, Zachary T. Baumer, Sophia A. Ulmer, Edgardo Ayala, Emily R. Rhodes, Jenna J. Guthmiller, Paul J. Steiner, Timothy A. Whitehead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antibodies are engineerable quantities in medicine. Learning antibody molecular recognition would enable the in silico design of high affinity binders against nearly any proteinaceous surface. Yet, publicly available experiment antibody sequ
Externí odkaz:
https://doaj.org/article/ad885af6bfcd4b0ba2768a7ecb7b47e4
Autor:
Monica B, Kirby, Timothy A, Whitehead
Publikováno v:
Methods in Molecular Biology ISBN: 9781071621516
Methods Mol Biol
Methods Mol Biol
Combinatorial mutagenesis is a method where multiple user-defined mutations are encoded at defined positions in a sequence. Combinatorial mutagenic libraries can be used in a variety of applications including evaluating fundamental questions about mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d93452d065058708a5dc593d6fe0ed
https://doi.org/10.1007/978-1-0716-2152-3_6
https://doi.org/10.1007/978-1-0716-2152-3_6
Autor:
Sean R. Cutler, Matthew S. Faber, Paul J. Steiner, Alexandra N. Borelli, Jesús Beltrán, Angélica V Medina-Cucurella, Monica B Kirby, Timothy A. Whitehead
Publikováno v:
Protein Eng Des Sel
User-defined mutagenic libraries are fundamental for applied protein engineering workflows. Here we show that unamplified oligo pools can be used to prepare site saturation mutagenesis libraries from plasmid DNA with near-complete coverage of desired
Publikováno v:
Protein Eng Des Sel
Generating combinatorial libraries of specific sets of mutations are essential for addressing protein engineering questions involving contingency in molecular evolution, epistatic relationships between mutations, as well as functional antibody and en
Autor:
Linghang Peng, Paul J. Steiner, Irene M. Francino-Urdaniz, Alison C. Leonard, Shawn Barman, Emily R. Rhodes, Cyrus M. Haas, Fangzhu Zhao, Monica B Kirby, Joseph G. Jardine, Timothy A. Whitehead, Kayla G. Sprenger
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell Reports
article-version (status) pre
article-version (number) 1
Cell Reports
The potential emergence of SARS-CoV-2 Spike (S) escape mutants is a threat to reduce the efficacy of existing vaccines and neutralizing antibody (nAb) therapies. An understanding of the antibody/S escape mutation landscape is urgently needed to preem