Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Monica B, Norton"'
1
Discovery of a Simple Picomolar Inhibitor of Cholesteryl Ester Transfer Protein
Autor: Jane L. Wang, Michael B. Tollefson, Margaret L. Grapperhaus, James A. Sikorski, Richard C. Durley, Monica B. Norton, Michele A. Promo, Michele A. Melton, Mark A. Massa, Emily J. Reinhard, Brian S. Hickory, William F. Vernier, Mark E. Smith, Yvette M. Fobian, Karen Regina, Bryan J. Witherbee, Daniel T. Connolly
Publikováno v: Journal of Medicinal Chemistry. 46:2152-2168
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b10e457203bbb1110208e3911dfa6aac
https://doi.org/10.1021/jm020528+
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2
Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents
Autor: Peter C. Isakson, James J. Li, David B. Reitz, G. D. Anderson, Monica B. Norton, Carol M. Koboldt, Jaime L. Masferrer, Gregory Susan A, Emily J. Reinhard, Karen Seibert, Yan Zhang, Ben S. Zweifel, William Perkins
Publikováno v: Journal of Medicinal Chemistry. 39:1846-1856
A novel series of terphenyl methyl sulfones and sulfonamides have been shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. The sulfonamide analogs 17 and 21 were found to be much more potent COX-2 inhibitors and orally active
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a6917aad0904e60acdaab0eb7bd0ed
https://doi.org/10.1021/jm950878e
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3
Lithiation and electrophilic substitution of 8-chlorodibenz[b,f][1,4]-oxazepine-10-tert-butylcarbamate: The preparation of novel fused heterocyclic derivatives of 8-chlorodibenzoxazepine
Autor: E. Ann Hallinan, David B. Reitz, Timothy J. Hagen, Sofya Tsymbalov, James J. Li, R. Alan Chrusciel, Monica B. Norton
Publikováno v: Journal of Heterocyclic Chemistry. 31:1689-1696
Lithiation of 8-chlorodibenz[b,f][1,4]oxazepine-10-tert-butylcarbamate (1) is described. Electrophilic substitution of the resulting N-Boc dibenzoxazepine α- lithioamine 2 with ketones, aldehydes, nitriles, iso-cyanates and imines, followed by an in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79d77e7138d302a566a1d27299084cb5
https://doi.org/10.1002/jhet.5570310670
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4
N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists
Autor: Maria A. Palomo, Danny J. Garland, Konrad F. Koehler, David B. Reitz, Monica B. Norton, Emily J. Reinhard, Gillian M. Olins, Susan T. Chen, Robert E. Manning, J. T. Collins, Ellen G. McMahon
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:1055-1060
The surmountable (competitive) N 1 -(2-methylphenyl)-2H-imidazol-2-one angiotensin II receptor antagonist SC-54628 is converted to an insurmountable (noncompetitive) antagonist SC-54629 by the addition of a methyl group at the 6-position of the pheny
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45e31096603038f887f225236b63745d
https://doi.org/10.1016/s0960-894x(00)80286-3
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9
ChemInform Abstract: Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active anti-Inflammatory Agents
Autor: Karen Seibert, Emily J. Reinhard, G. D. Anderson, David B. Reitz, William Perkins, Yan Zhang, Carol M. Koboldt, Gregory Susan A, James J. Li, Ben S. Zweifel, Monica B. Norton, Peter C. Isakson, Jaime L. Masferrer
Publikováno v: ChemInform. 27
A novel series of terphenyl methyl sulfones and sulfonamides have been shown to be highly potent and selective cyclooxygenase-2 (COX-2) inhibitors. The sulfonamide analogs 17 and 21 were found to be much more potent COX-2 inhibitors and orally active
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::133ae4b04e237650b8a7ea462b6ffb21
https://doi.org/10.1002/chin.199633109
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10
Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity
Autor: Olga V. Nemirovskiy, Mihir D. Parikh, Monica B. Norton, Jay M. Wendling, Michael S. Davies, Robert J. Mourey, Lakshman E. Rajagopalan, Toni A. Steiner, Ben S. Zweifel, Hideaki Shimada, Christine M. Kornmeier, Thomas P. Misko, Jaime L. Masferrer, Maria A. Payne, Larry E. Kahn, Stephen A. Kolodziej, Richard F Loeffler, Brenda L. Case
Publikováno v: The Journal of pharmacology and experimental therapeutics. 333(3)
Rho kinase, is the most widely studied downstream effector of the small Rho GTPase RhoA. Two Rho kinase isoforms have been described and are frequently referred to in the literature as ROCK1 and ROCK2. The RhoA-Rho kinase pathway has been implicated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a050f8933535407b1ce23153cb1f8587
https://pubmed.ncbi.nlm.nih.gov/20228155
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