Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Monica A. Istrate"'
Autor:
Hiltrud Brauch, Damjan Glavač, Yon-Dschun Ko, Ute Hamann, Thomas Illig, Caren Vollmert, Hans-Peter Fischer, Susanne Haas, Monica Adina Istrate, Werner Schroth, Christina Justenhoven, Matjaž Rokavec
Supplementary Data from A Novel Polymorphism in the Promoter Region of ERBB4 Is Associated with Breast and Colorectal Cancer Risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212fa24f0b5f43320159bad1a2beb9c
https://doi.org/10.1158/1078-0432.22441386.v1
https://doi.org/10.1158/1078-0432.22441386.v1
Autor:
Hiltrud Brauch, Damjan Glavač, Yon-Dschun Ko, Ute Hamann, Thomas Illig, Caren Vollmert, Hans-Peter Fischer, Susanne Haas, Monica Adina Istrate, Werner Schroth, Christina Justenhoven, Matjaž Rokavec
Purpose: The receptor tyrosine kinase ERBB4/HER4 plays a role in cell division, migration, differentiation, as well as apoptosis, and is frequently overexpressed in breast and colorectal tumors. To understand the role of genetic variations in the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace01008569869ab97848849e3d93f3d
https://doi.org/10.1158/1078-0432.c.6518466.v1
https://doi.org/10.1158/1078-0432.c.6518466.v1
Autor:
Thomas P. Burris, Bruce D. Pascal, Ruben D. Garcia-Ordonez, Jeffrey Alan Dodge, Monica A. Istrate, Michael J. Chalmers, Scott A. Busby, Yongjun Wang, Keith R. Stayrook, Patrick R. Griffin, Jun Zhang, Lorri L Burris, John B. Bruning, Douglas J. Kojetin
Publikováno v:
Nature structural & molecular biology
The vitamin D receptor (VDR) functions as an obligate heterodimer in complex with the retinoid X receptor (RXR). These nuclear receptors are multidomain proteins, and it is unclear how various domains interact with one another within the nuclear rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a2a0ab05cf6084e88a0f79db27f1b
http://europepmc.org/articles/PMC3087838
http://europepmc.org/articles/PMC3087838
Autor:
Jihong Xu, Stephan C. Schürer, Thomas P. Burris, William R. Roush, P. Naresh Kumar, J. J. Liu, Janelle L. Lauer, Yongjun Wang, Dusica Vidovic, Gail Wagoner, Laura A. Solt, Theodore M. Kamenecka, Patrick R. Griffin, Monica A. Istrate, Paul D. Drew, Philippe Nuhant
Publikováno v:
Nature
T-helper cells that produce interleukin-17 (T(H)17 cells) are a recently identified CD4(+) T-cell subset with characterized pathological roles in autoimmune diseases. The nuclear receptors retinoic-acid-receptor-related orphan receptors α and γt (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c1e09ccf1cd48da66039b764a08c22
http://europepmc.org/articles/PMC3148894
http://europepmc.org/articles/PMC3148894
Autor:
Wayne P. Bocchinfuso, Leah M. Helvering, Timothy P. Spicer, Monica A. Istrate, Peter Hodder, Jerrold A. Bernard, Yan Wang, Chahrzad Montrose-Rafizadeh, Naresh Kumar, Patrick R. Griffin, Timothy Ivo Richardson, Jeffrey Alan Dodge, Richard W. Zink
Publikováno v:
SLAS Discovery. 16:183-191
The retinoid acid receptor-related orphan receptors (RORs) represent important targets for the treatment of metabolic and immune disorders. Here the authors describe the application of AlphaScreen(®) technology to develop a high-throughput screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c3f60d6fe73b980a84b7e778c2b283
https://doi.org/10.1177/1087057110389040
https://doi.org/10.1177/1087057110389040
Autor:
Monica A. Istrate, Philippe Nuhant, Naresh Kumar, Yongjun Wang, Patrick R. Griffin, Michael D. Cameron, Thomas P. Burris, William R. Roush
Publikováno v:
ACS Chemical Biology. 5:1029-1034
The retinoic acid receptor-related receptors (RORs) are members of the nuclear receptor (NR) superfamily of transcription factors. Several NRs are still characterized as orphan receptors because ligands have not yet been identified for these proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc7cdabe19a5d300047724cc18d2dc7a
https://doi.org/10.1021/cb100223d
https://doi.org/10.1021/cb100223d
Autor:
Christina Justenhoven, Monica Adina Istrate, Hiltrud Brauch, Matjaž Rokavec, Susanne Haas, Werner Schroth, Hans-Peter Fischer, Ute Hamann, Damjan Glavač, Thomas Illig, Caren Vollmert, Yon-Dschun Ko
Publikováno v:
Clinical Cancer Research. 13:7506-7514
Purpose: The receptor tyrosine kinase ERBB4/HER4 plays a role in cell division, migration, differentiation, as well as apoptosis, and is frequently overexpressed in breast and colorectal tumors. To understand the role of genetic variations in the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9050be7d4a49d39111b28397e0ae95a
https://doi.org/10.1158/1078-0432.ccr-07-0457
https://doi.org/10.1158/1078-0432.ccr-07-0457
Autor:
Juliana J. Conkright, Thomas P. Burris, William R. Roush, Monica A. Istrate, Naresh Kumar, Dana S. Kuruvilla, Patrick R. Griffin, Theodore M. Kamenecka, Yongjun Wang, Scott A. Busby, Michael D. Cameron
Publikováno v:
ACS chemical biology. 6(6)
Retinoids are potent forms of vitamin A and are involved in a broad range of physiological processes and the pharmacological effects of retinoids are primarily mediated by the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs). Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972d32f6de11ea138b451c49314b6dc7
https://pubmed.ncbi.nlm.nih.gov/21381756
https://pubmed.ncbi.nlm.nih.gov/21381756
Publikováno v:
Biochemical and biophysical research communications. 393(4)
Induction of the major drug metabolizing enzyme CYP3A4 by xenobiotics contributes to the pronounced interindividual variability of its expression and often results in clinically relevant drug-drug interactions. It is mainly mediated by PXR, which reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb93801006028578b5ac645a99ec6c8
https://pubmed.ncbi.nlm.nih.gov/20171174
https://pubmed.ncbi.nlm.nih.gov/20171174
Autor:
Yongjun Wang, Thomas P. Burris, Monica A. Istrate, Laura A. Solt, Ruben D. Garcia-Ordonez, Patrick R. Griffin, Naresh Kumar, Juliana J. Conkright, Scott A. Busby
Publikováno v:
Molecular pharmacology. 77(2)
Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological processes including hepatic gluconeogenesis, lipid metabolism, circadian rhythm, and immune function. Here we present the first high-affinity synthetic ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e869c625ef5e72f74745328f37e21ce
https://pubmed.ncbi.nlm.nih.gov/19887649
https://pubmed.ncbi.nlm.nih.gov/19887649