Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Monica, Bubenik"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Autor:
Sui Xiong Cai, Serge Lamothe, Candace Crogan-Grundy, Shailaja Kasibhatla, Monica Bubenik, William Kemnitzer, John Drewe, Henriette Gourdeau, Giorgio Attardo, Yan Wang, Songchun Jiang, Real Denis, Denis Labrecque, Ben Tseng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:603-607
As a continuation of our efforts to discover and develop apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored modifications at the 2- and 3-positions. It was found that replacement of the 3-cyano group by an ester, including
Autor:
Jian Wang, Anne-Laure Grillot, Carl Poisson, Simon Giroux, Nigel Ewing, Youssef L. Bennani, Rebecca S. Shawgo, Ronald Grey, Louis Vaillancourt, Nathalie Chauret, Darius Bilimoria, Olivier Nicolas, Lucille L’Heureux, Subajini Selliah, Kevin M. Cottrell, B. Govinda Rao, Constantin Yannopoulos, Guy Falardeau, Monica Bubenik, Laval C. Chan, James A. Henderson, Sanjoy Kumar Das, Francois Denis, T. Jagadeeswar Reddy, Caroline Cadilhac, Morris Mark A, Oswy Z. Pereira, Evelyne Dietrich, Nagraj Mani, John Maxwell, Francoise Berlioz-Seux, Bingcan Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
The treatment of HCV with highly efficacious, well-tolerated, interferon-free regimens is a compelling clinical goal. Trials employing combinations of direct-acting antivirals that include NS5A inhibitors have shown significant promise in meeting thi
Autor:
Anne-Laure Grillot, Nigel Ewing, Youssef L. Bennani, Simon Giroux, Nathalie Chauret, Caroline Cadilhac, Kevin M. Cottrell, Olivier Nicolas, T. Jagadeeswar Reddy, Evelyne Dietrich, Lucille L’Heureux, Francois Denis, Oswy Z. Pereira, Rebecca S. Shawgo, Jinwang Xu, Nagraj Mani, Francoise Berlioz-Seux, Jian Wang, Sanjoy Kumar Das, John Maxwell, Bingcan Liu, James A. Henderson, Louis Vaillancourt, Subajini Selliah, Guy Falardeau, Laval C. Chan, Morris Mark A, Carl Poisson, Darius Bilimoria, Monica Bubenik
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
Inhibitors of the HCV NS5A nonstructural protein are showing promising clinical potential in the treatment of hepatitis C when used in combination with other direct-acting antiviral agents. Current NS5A clinical candidates such as daclatasvir, ledipa
Publikováno v:
Tetrahedron Letters. 44:8261-8263
Recently we have reported a novel class of tetrahydrofuran phosphonates of which trans guanine nucleotide analog 1a showed potent antiviral activity as well as antitumor activity. In this paper we describe a stereoselective route where the key step i
Publikováno v:
Inorganic Chemistry. 32:4621-4631
Autor:
Monica Bubenik, Frédéric Bergeron, Cathy Poirier, Giorgio Attardo, Brigitte Grouix, Lorraine Leblond, Karen Meerovitch, Terry L. Bowlin, Laval Chan, Henriette Gourdeau
Publikováno v:
Vascular pharmacology. 40(2)
Integrin-mediated cell adhesion is necessary for endothelial cell proliferation and apoptosis, which is a major determinant in tumor-induced angiogenesis. In this study, we compared two novel, structurally similar, Arg-Gly-Asp (RGD) peptidomimetic co
Publikováno v:
ChemInform. 34
We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC 50 values in the μM range. The synthesis as well as structure–activity relationship are described.
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(3)
A series of alpha(v)beta(3) antagonists based on a thiophene scaffold were synthesized via two routes and evaluated for in vitro biological activity. We have identified several structurally similar antagonists with different selectivities towards alp