Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Monica, Borgatti"'
Autor:
Valentino Bezzerri, Valentina Gentili, Martina Api, Alessia Finotti, Chiara Papi, Anna Tamanini, Christian Boni, Elena Baldisseri, Debora Olioso, Martina Duca, Erika Tedesco, Sara Leo, Monica Borgatti, Sonia Volpi, Paolo Pinton, Giulio Cabrini, Roberto Gambari, Francesco Blasi, Giuseppe Lippi, Alessandro Rimessi, Roberta Rizzo, Marco Cipolli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Patients with cystic fibrosis are not reporting particularly sever outcomes upon SARS-CoV-2 infection. Here, the authors demonstrate decreased ACE2 levels is cystic fibrosis airway epithelia associated with impaired viral entry and replication.
Externí odkaz:
https://doaj.org/article/469ec52418bc4d8eb0ef6499688e03e5
Autor:
Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Cristina Zuccato, Marco Prosdocimi, Monica Borgatti, Lucia Carmela Cosenza
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug re
Externí odkaz:
https://doaj.org/article/39076482c34641b6a1f45b12ca0a19af
Autor:
M.L.P. Michele Lipucci Di Paola, C.Z. Cristina Zuccato, L.C.C. Lucia Carmela Cosenza, M.Z. Matteo Zurlo, M.B. Monica Borgatti, I.L. Ilaria Lampronti, C.T.S. Chris Sotirelis, M.P. Marco Prosdocimi, R.G. Roberto Gambari, A.F. Alessia Finotti
Publikováno v:
HemaSphere, Vol 7, Iss S1, Pp 42-42 (2023)
Externí odkaz:
https://doaj.org/article/356268a7eee34d0eb3d62fbccf371ab2
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1248-1257 (2021)
In certain cancers, such as breast, prostate and some lung and skin cancers, the gene for the enzyme catalysing the second and last step in proline synthesis, δ1-pyrroline-5-carboxylate (P5C) reductase, has been found upregulated. This leads to a hi
Externí odkaz:
https://doaj.org/article/cf5422752dd54a28a05e0754b06ba4e9
Autor:
Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Chiara Papi, Elisabetta D’Aversa, Giulia Breveglieri, Ilaria Lampronti, Alessia Finotti, Monica Borgatti, Chiara Scapoli, Alice Stievano, Monica Fortini, Eric Ramazzotti, Nicola Marchetti, Marco Prosdocimi, Maria Rita Gamberini, Roberto Gambari
Publikováno v:
Therapeutic Advances in Hematology, Vol 13 (2022)
Introduction: β-thalassemia is caused by autosomal mutations in the β-globin gene, which induce the absence or low-level synthesis of β-globin in erythroid cells. It is widely accepted that a high production of fetal hemoglobin (HbF) is beneficial
Externí odkaz:
https://doaj.org/article/3a428c6ac29340b587bac650085e82e1
Autor:
Salvatore Novello, Daniela Mercatelli, Federica Albanese, Chiara Domenicale, Alberto Brugnoli, Elisabetta D'Aversa, Silvia Vantaggiato, Sandra Dovero, Valentina Murtaj, Luca Presotto, Monica Borgatti, Derya R. Shimshek, Erwan Bezard, Rosa Maria Moresco, Sara Belloli, Michele Morari
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105579- (2022)
The G2019S mutation of LRRK2 represents a risk factor for idiopathic Parkinson's disease. Here, we investigate whether LRRK2 kinase activity regulates susceptibility to the environmental toxin 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP). G201
Externí odkaz:
https://doaj.org/article/055453400ae74341863a1b9645ff1160
Autor:
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for
Externí odkaz:
https://doaj.org/article/63d4e9c8bcee492a904682a88820f723
Autor:
Giulio Cabrini, Alessandro Rimessi, Monica Borgatti, Ilaria Lampronti, Alessia Finotti, Paolo Pinton, Roberto Gambari
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
A hallmark of cystic fibrosis (CF) chronic respiratory disease is an extensive neutrophil infiltrate in the mucosa filling the bronchial lumen, starting early in life for CF infants. The genetic defect of the CF Transmembrane conductance Regulator (C
Externí odkaz:
https://doaj.org/article/e68c38e6d01e43e7ab8b32eae9b32f8c
Autor:
Jessica Gasparello, Matteo Allegretti, Elisa Tremante, Enrica Fabbri, Carla Azzurra Amoreo, Paolo Romania, Elisa Melucci, Katia Messana, Monica Borgatti, Patrizio Giacomini, Roberto Gambari, Alessia Finotti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-11 (2018)
Abstract Background Circulating tumor DNA (ctDNA) and miRNA (ctmiRNA) are promising biomarkers for early tumor diagnosis, prognosis and monitoring, and to predict therapeutic response. However, a clear understanding of the fine control on their circu
Externí odkaz:
https://doaj.org/article/225dc0b409264df2ace9470eb1cb5864
Autor:
Francesca Salvatori, Mariangela Pappadà, Giulia Breveglieri, Elisabetta D’Aversa, Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Monica Borgatti
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Nonsense mutations promote premature translational termination, introducing stop codons within the coding region of mRNAs and causing inherited diseases, including thalassemia. For instance, in β039 thalassemia the CAG (glutamine
Externí odkaz:
https://doaj.org/article/f62c4bbe71144bcc957913ef4e54766e