Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease

Autor: Amrisha Bhosle, Sena Bae, Yancong Zhang, Eunyoung Chun, Julian Avila-Pacheco, Ludwig Geistlinger, Gleb Pishchany, Jonathan N Glickman, Monia Michaud, Levi Waldron, Clary B Clish, Ramnik J Xavier, Hera Vlamakis, Eric A Franzosa, Wendy S Garrett, Curtis Huttenhower

Publikováno v: Molecular Systems Biology, Vol 20, Iss 4, Pp 338-361 (2024)

Abstract Microbial biochemistry is central to the pathophysiology of inflammatory bowel diseases (IBD). Improved knowledge of microbial metabolites and their immunomodulatory roles is thus necessary for diagnosis and management. Here, we systematical

Externí odkaz: https://doaj.org/article/9dc7c22482b749b1948ab95a7d3ce206

Comparative genomics and genome biology of Campylobacter showae

Autor: Tiffany Hsu, Matthew R. Gemmell, Eric A. Franzosa, Susan Berry, Indrani Mukhopadhya, Richard Hansen, Monia Michaud, Hans Nielsen, William G. Miller, Henrik Nielsen, Mona Bajaj-Elliott, Curtis Huttenhower, Wendy S. Garrett, Georgina L. Hold

Publikováno v: Emerging Microbes and Infections, Vol 8, Iss 1, Pp 827-840 (2019)

ABSTRACTCampylobacter showae a bacterium historically linked to gingivitis and periodontitis, has recently been associated with inflammatory bowel disease and colorectal cancer. Our aim was to generate genome sequences for new clinical C. showae stra

Externí odkaz: https://doaj.org/article/72621a9f99264a12a5ca4b5b044904e0

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

Autor: Eunyoung Chun, Sydney Lavoie, Monia Michaud, Carey Ann Gallini, Jason Kim, Genevieve Soucy, Robert Odze, Jonathan N. Glickman, Wendy S. Garrett

Publikováno v: Cell Reports, Vol 12, Iss 2, Pp 244-257 (2015)

Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that intratumoral CCL2 levels increased i

Externí odkaz: https://doaj.org/article/964985b2b52640db904814df283c194f

Comparative genomics and genome biology of Campylobacter showae

Autor: Georgina L. Hold, Wendy S. Garrett, Indrani Mukhopadhya, Monia Michaud, Hans Ove Nielsen, Mona Bajaj-Elliott, Curtis Huttenhower, Henrik Nielsen, William G. Miller, Susan H. Berry, Tiffany Hsu, Matthew Gemmell, Eric A. Franzosa, Richard Hansen

Publikováno v: Emerging Microbes & Infections
Hsu, T, Gemmell, M R, Franzosa, E A, Berry, S, Mukhopadhya, I, Hansen, R, Michaud, M, Nielsen, H, Miller, W G, Nielsen, H, Bajaj-Elliott, M, Huttenhower, C, Garrett, W S & Hold, G L 2019, ' Comparative genomics and genome biology of Campylobacter showae ', Emerging microbes & infections, vol. 8, no. 1, pp. 827-840 . https://doi.org/10.1080/22221751.2019.1622455

Campylobacter showae a bacterium historically linked to gingivitis and periodontitis, has recently been associated with inflammatory bowel disease and colorectal cancer. Our aim was to generate genome sequences for new clinical C. showae strains and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd7388dedcea6812ca04a3fefebb197
http://europepmc.org/articles/PMC6567213

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Autor: Talia Golan, Alexander Brandis, Judith Sandbank, Zachary A. Cooper, Matteo Ligorio, Sangeeta N. Bhatia, Jonathan Livny, Noam Shental, Jason B. Fleming, Sarah P. Thayer, Alexandre Reuben, Tal Danino, Candice Gurbatri, Sunia A. Trauger, Anna Mandinova, Vancheswaran Gopalakrishnan, Iris Barshack, Mark W. Hurd, Dirk Gevers, Deborah Nejman, Matthew Skalak, Jennifer A. Wargo, Carrie M. Mosher, Wendy S. Garrett, Jeffrey Bu, Kelly Chatman, Stephen Johnston, Todd R. Golub, Michal Barzily-Rokni, Nancy Gavert, Michael P. Kim, Cristina R. Ferrone, Keith T. Flaherty, Dennie T. Frederick, Curtis Huttenhower, Roi Avraham, Ravid Straussman, Matthew H.G. Katz, Yaara Zwang, David Smith, Monia Michaud, Kevin Shee, Oliver Jonas, Leore T. Geller, Anirban Maitra, Christoph A. Thaiss, Garold Fuks

Publikováno v: Science. 357:1156-1160

Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2′,2′-difluorodeoxycytidine) into its inactive f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73de7a5f35b9daf75ea6546a5eaf0a29
https://doi.org/10.1126/science.aah5043