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Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability

Autor: Daniela Miranda, Francisca Lopes, Inês S. Albuquerque, Rui Moreira, Margarida Sanches-Vaz, Marta Machado, Moni Sharma, Maria de Jesus Perry, Joana Magalhães, Miguel Prudêncio, Philip J. Rosenthal, Rita Capela, Raquel F. M. Frade, Jiri Gut

Publikováno v: European Journal of Medicinal Chemistry

Hybrid compounds may play a critical role in the context of the malaria eradication agenda, which will benefit from therapeutic tools active against the symptomatic erythrocytic stage of Plasmodium infection, and also capable of eliminating liver sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18917fd79c320b8c1859cb9d56371cde
https://doi.org/10.1016/j.ejmech.2018.02.048

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Facile ligand-free Pd-catalyzed tandem C–C/C–N coupling reaction: a novel access to highly diverse tetrazole tag isoindoline derivatives

Autor: Ruchir Kant, Sanjeev K. Shukla, Irfan Khan, Moni Sharma, Rohit Mahar, Shahnawaz Khan, Prem M. S. Chauhan

Publikováno v: Tetrahedron Letters. 56:5401-5408

A novel and robust route for the synthesis of diversely substituted isoindoline skeletons through a ligand-free Pd-catalyzed cascade consisting of isocyanide insertion into Ugi-tetrazole has been developed. The tetrazole precursor is prepared in one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::905a3c488e88b83bfcc7d72abe1f5257
https://doi.org/10.1016/j.tetlet.2015.08.008

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New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl)thiazol-4(%H)-one as potent antitubercular agents

Autor: Kuldeep Chauhan, Moni Sharma, Prem M. S. Chauhan, Priyanka Trivedi, Vinita Chaturvedi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 24:4166-4170

In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1e8b81fee9bf6b514eaab44647024d
https://doi.org/10.1016/j.bmcl.2014.07.061

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Design and Synthesis of a New Class of 4-Aminoquinolinyl- and 9-Anilinoacridinyl Schiff Base Hydrazones as Potent Antimalarial Agents

Autor: Kumkum Srivastava, Shiv Vardan Singh, Prem M. S. Chauhan, Rajeev K. Srivastava, Jitendra Kumar Saxena, Kuldeep Chauhan, Moni Sharma, Sunil K. Puri

Publikováno v: Chemical Biology & Drug Design. 84:175-181

A series of novel 4-aminoquinolinyl and 9-anilinoacridinyl Schiff base hydrazones have been synthesized and evaluated for their antimalarial activity. All compounds were evaluated in vitro for their antimalarial activity against chloroquine-sensitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0050825f182c69bbb9a9a67840adcb
https://doi.org/10.1111/cbdd.12289

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Assessing the risk factors of suicide among adolescents and evaluating the knowledge on suicide prevention at Goalpara, Assam

Autor: Tarulata Kakati Majhi, Rita Moni Sharma

Publikováno v: Indian Journal of Psychiatric Nursing. 16:72

Background of the Study: A study was conducted to assess the risk factors of suicide among adolescents and evaluate the knowledge on suicide prevention in selected colleges of Goalpara district, Assam. Aims: Aims of the study were to reduce suicide r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6517b3ac1b15a3c38768431440473d70
https://doi.org/10.4103/iopn.iopn_24_19

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Potassium carbonate mediated unusual transformation of 2,3-dihydroquinazolinone via cascade reaction

Autor: Ruchir Kant, Rohit Mahar, Sanjeev K. Shukla, Prem M. S. Chauhan, Moni Sharma

Publikováno v: Tetrahedron Letters. 54:6171-6177

An unusual potassium carbonate mediated transformation of 2,3-dihydroquinazolinone by a one-pot operation is reported under mild conditions. In addition, it is interesting to report the regioselective transformation of 3-(2-bromophenyl)-2-isopropyl-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e69d343a5bca0c887a5350b5b685898d
https://doi.org/10.1016/j.tetlet.2013.08.095

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Discovery of Triazine Mimetics As Potent Antileishmanial Agents

Autor: Suman Gupta, Rahul Shivahare, Yenamandra S. Prabhakar, Prem M. S. Chauhan, Moni Sharma, Utsab Debnath, Kuldeep Chauhan

Publikováno v: ACS Medicinal Chemistry Letters. 4:1108-1113

The World Health Organization has classified the leishmaniasis as a major tropical disease. The discovery of new compounds for leishmaniasis is therefore a pressing concern for the anti-infective research program. We have synthesized 19 compounds of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2447aa7daf94857da4e96f703075e9ff
https://doi.org/10.1021/ml400317e

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Discovery of a New Class of Natural Product-Inspired Quinazolinone Hybrid as Potent Antileishmanial agents

Autor: Manish Kumar Suthar, Kuldeep Chauhan, Brijesh Kumar, Abhisheak Sharma, Preeti Vishwakarma, Prem M. S. Chauhan, Jawahar Lal, Rahul Shivahare, Jitendra Kumar Saxena, Preeti Chandra, Suman Gupta, Moni Sharma

Publikováno v: Journal of Medicinal Chemistry. 56:4374-4392

The high potential of quinazolinone containing natural products and their derivatives in medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridization. Most of the synthesize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4886f0e229379932098596cda11a08
https://doi.org/10.1021/jm400053v

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