Eicosanoids and Oxidative Stress in Diabetic Retinopathy

Autor: Mong-Heng Wang, George Hsiao, Mohamed Al-Shabrawey

Publikováno v: Antioxidants, Vol 9, Iss 6, p 520 (2020)

Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR) because the retina has high vascularization and long-time light exposition. Cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes can

Externí odkaz: https://doaj.org/article/a2c3ad1cbadc4e648c393b17a3420ea9

Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibition.

Autor: Luyun Wang, Yang Liu, Huamin Wang, Xun Liu, Jie Chen, Mong-Heng Wang, Jingfeng Wang, Hui Huang

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94400 (2014)

Inner medulla collecting duct (IMCD) cells are the key part for urinary concentration. Hypotonic stress may trigger apoptosis of IMCD cells and induce renal injury. Epoxyeicosatrienoic acids (EETs) play an important role in anti-apoptosis, but their

Externí odkaz: https://doaj.org/article/be5ccceacd454c2a9580207a24e58b69

Ergosta-7,9(11),22-trien-3β-ol Alleviates Intracerebral Hemorrhage-Induced Brain Injury and BV-2 Microglial Activation

Autor: Mong Heng Wang, Shu Hsien Huang, Jing Lun Yen, Fan Li Lin, Chih Kuang Chen, Ping Huei Tsai, Po Jen Hsueh, Che Jen Hsiao, Yueh-Hsiung Kuo, George Hsiao

Publikováno v: Molecules, Vol 26, Iss 2970, p 2970 (2021)
Molecules
Volume 26
Issue 10

Intracerebral hemorrhage (ICH) is a devastating neurological disorder characterized by an exacerbation of neuroinflammation and neuronal injury, for which few effective therapies are available at present. Inhibition of excessive neuroglial activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a10642d8e0263fd74edef1275781a0
https://www.mdpi.com/1420-3049/26/10/2970

Targeting of 12/15-Lipoxygenase in retinal endothelial cells, but not in monocytes/macrophages, attenuates high glucose-induced retinal leukostasis

Autor: Khaled Elmasry, Amany Tawfik, Nader Sheibani, Khaled A. Hussein, Mong Heng Wang, Mohamed El-Shafey, Babak Baban, Ahmed Ibrahim, Mohamed Al-Shabrawey, Heba Saleh

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1862:636-645

Aims Our previous studies have established a role for 12/15-lipoxygenase (LO) in mediating the inflammatory response in diabetic retinopathy (DR). However, the extent at which the local or systemic induction of 12/15-LO activity involved is unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b422fc7d9a53703e0a3f311b14e14e1
https://doi.org/10.1016/j.bbalip.2017.03.010

Transcriptional profiling of uterine leiomyoma rats treated by a traditional herb pair, Curcumae rhizoma and Sparganii rhizoma

Autor: Cheng Peng, Xingming Shi, Cheng Hao Yu, Teng Peng, Yao Li, R. Clinton Webb, Jin Shuang Zhao, Hui Zhao, Dong Cheng Shen, Qiu Xia Xu, Wei Jun Ding, Mong Heng Wang

Publikováno v: Brazilian Journal of Medical and Biological Research
Brazilian Journal of Medical and Biological Research, Volume: 52, Issue: 6, Article number: e8132, Published: 27 MAY 2019
Brazilian Journal of Medical and Biological Research, Vol 52, Iss 6
Brazilian Journal of Medical and Biological Research v.52 n.6 2019
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC

The aim of this study was to elucidate the concise effects of a traditional herb pair, Curcumae rhizoma-Sparganii rhizoma (CRSR), on uterine leiomyoma (UL) by analyzing transcriptional profiling. The UL rat model was made by intramuscular injection o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b5bd7ab6fbcbe8b969ed7dac69a186
https://doi.org/10.1590/1414-431x20198132