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Akademický článek

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.

Autor: Foloppe N; Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge, CB21 6GB, UK. n.foloppe@vernalis.com, Benwell K, Brooks TD, Kennett G, Knight AR, Misra A, Monck NJ

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Aug 01; Vol. 19 (15), pp. 4183-90. Date of Electronic Publication: 2009 Jun 02.

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Akademický článek

Discovery of a novel class of selective human CB1 inverse agonists.

Autor: Foloppe N; Vernalis (R&D) Ltd, Granta Park, Abington, Cambridge CB21 6GB, UK. n.foloppe@vernalis.com, Allen NH, Bentley CH, Brooks TD, Kennett G, Knight AR, Leonardi S, Misra A, Monck NJ, Sellwood DM

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Feb 01; Vol. 18 (3), pp. 1199-206. Date of Electronic Publication: 2007 Dec 07.

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Akademický článek

5-HT2C ligands: recent progress.

Autor: Monck NJ; Vernalis (R&D) Ltd., 613 Reading Road, Winnersh, Wokingham, Berkshire, RG41 5UA, UK., Kennett GA

Publikováno v: Progress in medicinal chemistry [Prog Med Chem] 2008; Vol. 46, pp. 281-390.

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Akademický článek

Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.

Autor: Richter HG; F. Hoffmann-La Roche Ltd, Discovery Research, 4070 Basel, Switzerland. hans.richter@roche.com, Adams DR, Benardeau A, Bickerdike MJ, Bentley JM, Blench TJ, Cliffe IA, Dourish C, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, Misra A, Mizrahi J, Monck NJ, Plancher JM, Roever S, Roffey JR, Taylor S, Vickers SP

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Mar 01; Vol. 16 (5), pp. 1207-11. Date of Electronic Publication: 2005 Dec 19.

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Akademický článek

Highly stereoselective Michael addition reactions of CamTHP*-desymmetrized glycinamide for the synthesis of functionally dense amino acid derivatives.

Autor: Dixon DJ; Department of Chemistry, University of Manchester, Manchester, M13 9PL, U.K. darren.dixon@man.ac.uk, Horan RA, Monck NJ, Berg P

Publikováno v: Organic letters [Org Lett] 2004 Nov 25; Vol. 6 (24), pp. 4427-9.

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Akademický článek

CamTHP*OH: a camphor-derived delta-lactol auxiliary for the effective desymmetrization of attached glycinamide residues. Asymmetric synthesis of alpha-amino carbonyl compounds.

Autor: Dixon DJ; Department of Chemistry, University of Manchester, Manchester M13 9PL, U.K. darren.dixon@man.ac.uk, Horan RA, Monck NJ

Publikováno v: Organic letters [Org Lett] 2004 Nov 25; Vol. 6 (24), pp. 4423-6.

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Akademický článek

Indoline derivatives as 5-HT(2C) receptor agonists.

Autor: Bentley JM; Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, Berkshire RG41 5UA, UK. j.bentley@vernalis.com, Adams DR, Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, Dawson CE, Dourish CT, Duncton MA, Gaur S, George AR, Giles PR, Hamlyn RJ, Kennett GA, Knight AR, Malcolm CS, Mansell HL, Misra A, Monck NJ, Pratt RM, Quirk K, Roffey JR, Vickers SP, Cliffe IA

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 May 03; Vol. 14 (9), pp. 2367-70.

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Akademický článek

3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.

Autor: Bebbington D; Department of Chemistry, Cerebrus, Winnersh, Wokingham, UK. david_bebbington@vpharm.com, Monck NJ, Gaur S, Palmer AM, Benwell K, Harvey V, Malcolm CS, Porter RH

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2000 Jul 27; Vol. 43 (15), pp. 2779-82.

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