Novel, tightly structurally related N-myristoyltransferase inhibitors display equally potent yet distinct inhibitory mechanisms

Autor: Rivière, Frédéric, Dian, Cyril, Dutheil, Rémi F., Monassa, Paul, Giglione, Carmela, Meinnel, Thierry

Publikováno v: In Structure 3 October 2024 32(10):1737-1750

Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging.

Autor: Monassa P; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France., Rivière F; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France., Dian C; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France., Frottin F; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France., Giglione C; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France. Electronic address: carmela.giglione@i2bc.paris-saclay.fr., Meinnel T; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette cedex, France. Electronic address: thierry.meinnel@i2bc.paris-saclay.fr.

Publikováno v: Methods in enzymology [Methods Enzymol] 2023; Vol. 684, pp. 135-166. Date of Electronic Publication: 2023 Mar 28.