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Akademický článek

Identification and validation of lung adenocarcinoma (LUAD)-associated targets for monascin from the extracts of Monascus purpureus-fermented rice: Compound preparation, high-throughput genome sequencing and bioinformatics analysis

Autor: Xilinqiqige Bao, Hanqing Li, Jiayin Xu, Xiaoqing Liu, Runa A, Jianming Chen, Fengzheng Chen, Nan Ya, Rigula Sa

Publikováno v: Saudi Pharmaceutical Journal, Vol 32, Iss 12, Pp 102215- (2024)

Despite the remarkable bioactivities exhibited by monascin against several tumors, its therapeutic targets remain unexplored. In this study, our objective is to identify therapeutic targets based on the antitumor activity of monascin against lung ade

Externí odkaz: https://doaj.org/article/4257a2378a2048b9b786fa4aa700eb9c

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Akademický článek

Revealing the Hypoglycemic Effect of Red Yeast Rice: Perspectives from the Inhibition of α-Glucosidase and the Anti-Glycation Capability by Ankaflavin and Monascin

Autor: Shufen Wu, Changyan Dong, Meihui Zhang, Yi Cheng, Xiaobo Cao, Benxu Yang, Chao Li, Xin Peng

Publikováno v: Foods, Vol 13, Iss 10, p 1573 (2024)

Red yeast rice dietary supplements have been proven to ameliorate hyperglycemia, but the mechanism was unclear. In this work, ankaflavin (AK) and monascin (MS), as typical pigments derived from red yeast rice, were found to exert noteworthy inhibitor

Externí odkaz: https://doaj.org/article/65603a7abf794a048d6a3d9eb4a25cfb

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Akademický článek

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Akademický článek

Monascin and ankaflavin prevents metabolic disorder by blood glucose regulatory, hypolipidemic, and anti-inflammatory effects in high fructose and high fat diet-induced hyperglycemic rat

Autor: Che-Wei Lin, Chun-Hung Lin, Ya-Wen Hsu, Tzu-Ming Pan, Chun-Lin Lee

Publikováno v: Journal of Functional Foods, Vol 104, Iss , Pp 105537- (2023)

Monascin (MS) and ankaflavin (AK) produced by Monascus purpureus fermented red mold dioscorea (RMD) elicit an anti-diabetes effect in streptozocin-induced type 1 diabetes. However, their effects on preventing metabolic disorder with type 2 diabetes i

Externí odkaz: https://doaj.org/article/0935f23df63b437eb1ef9fa934f97231

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Akademický článek

Monascus-fermented metabolites repressed amyloid β-peptide-induced neurotoxicity and inflammatory response in in vitro and in vivo studies

Autor: Che-Wei Lin, Pei-Ying Lin, Ya-Wen Hsu, Tzu-Ming Pan, Chun-Lin Lee

Publikováno v: Journal of Functional Foods, Vol 104, Iss , Pp 105509- (2023)

Monascus purpureus-produced monascin (MS) and ankaflavin (AK) have the potential to improve memory deficiency in Alzheimer's disease rat models; however, the mechanisms are still unclear. We aimed to investigate the effects and mechanisms of MS and A

Externí odkaz: https://doaj.org/article/b9a8f518ad024e1eb2dfca22e02a4b7a

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Akademický článek

Toxicological evaluation of the red mold rice extract, ANKASCIN 568-R: 13-week chronic toxicity, and genotoxicity studies

Autor: Che-Wei Lin, Hsiao-Lin Chen, Yu-Hui Yang, Ya-Yuan Chen, Ya-Wen Hsu, Tzu-Ming Pan

Publikováno v: Toxicology Reports, Vol 9, Iss , Pp 356-365 (2022)

ANKASCIN 568-R is an extract derived from red mold rice (RMR) fermented using Monascus purpureus NTU 568. RMR fermented using M. purpureus NTU 568 prevents cardiovascular diseases and decreases blood lipid levels. This study evaluates the safety of A

Externí odkaz: https://doaj.org/article/c5c7f37c12604ee7aefb977c6b8428c8

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Akademický článek

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Akademický článek

Monascin abrogates RANKL-mediated osteoclastogenesis in RAW264.7 cells via regulating MAPKs signaling pathways

Autor: Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Osteoclasts (OCs) are multinucleated cells that play a major role in osteolytic diseases such as osteoporosis. Monascin (Ms) is one of the active substances in the traditional Chinese medicine red yeast rice. Studies have found that red yeast rice ca

Externí odkaz: https://doaj.org/article/ad6cea6ca6fd4e66bada73bc3d63b7d7

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Akademický článek

Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway

Autor: Yong-Xiang Shi, Wei-Shan Chen

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 23, Iss 4, Pp 461-468 (2020)

Objective(s): The pathophysiology of neurodegenerative diseases is complicated, in which inflammatory reactions play a vital role. Microglia cells activation, an essential process of neuroinflammation, can produce neurotoxic molecules and neurotrophi

Externí odkaz: https://doaj.org/article/945f27fd1c86438580c5a4b9e9dd7700

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