Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Monacolin J"'
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Akademický článek
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Autor:
Chenxiao Bai, Yiqi Liu, Xinjie Chen, Zhilan Qian, Haifeng Liu, Xiangshan Zhou, Yuanxing Zhang, Menghao Cai
Publikováno v:
Bioresources and Bioprocessing, Vol 7, Iss 1, Pp 1-9 (2020)
Abstract Background Monacolin J (MJ) is a key intermediate for the synthesis of cholesterol-lowering drug simvastatin. Current industrial production of MJ involves complicated chemical hydrolysis of microbial fermented lovastatin. Recently, heterolog
Externí odkaz:
https://doaj.org/article/4903a3e6900749c18fe6cf2613d36ef8
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 407 (2022)
Monacolin J (MJ), a key precursor of Lovastatin, could synthesize important statin drug simvastatin by hydrolyzing lovastatin and adding different side chains. In this study, to reduce the cumbersome hydrolysis of lovastatin to produce MJ in the nati
Externí odkaz:
https://doaj.org/article/9bb3c58c864e42b3bea5690303fcf4d7
Publikováno v:
Pharmaceuticals, Vol 14, Iss 10, p 981 (2021)
Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular di
Externí odkaz:
https://doaj.org/article/96fd6e864b9b493f93631bb544a85449
Autor:
Xuefeng Lu, Yajing Liang
Publikováno v:
J Biol Chem
The lovastatin hydrolase PcEST from the fungus Penicillium chrysogenum exhibits enormous potential for industrial-scale applications in single-step production of monacolin J, the key precursor for synthesis of the cholesterol-lowering drug simvastati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60b57ac5eef284f85dc33fbbda2758d
https://doi.org/10.1016/s0021-9258(17)49914-5
https://doi.org/10.1016/s0021-9258(17)49914-5
Autor:
Qi Liu, Mingqiang Xu, Xiangshan Zhou, Menghao Cai, Zhilan Qian, Yuanxing Zhang, Jiahui Yu, Chenxiao Bai, Yiqi Liu, Qin Xu, Qiangqiang Peng
Publikováno v:
Metabolic Engineering. 54:275-284
Many natural drugs use acetyl-CoA as the key biosynthetic precursor. While in eukaryotic chassis host like yeast, efficient biosynthesis of these drugs is often hampered by insufficient acetyl-CoA supply because of its compartmentalized metabolism. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a010b9483347826ed125b8774f2e476
https://doi.org/10.1016/j.ymben.2019.05.001
https://doi.org/10.1016/j.ymben.2019.05.001
Publikováno v:
Applied Microbiology and Biotechnology
The goal of the study was to compare the production of secondary metabolites by Aspergillus terreus ATCC 20542 under the conditions of submerged mono- and co-cultivation. The suggested experimental scheme encompassed a diverse set of co-culture initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee071bdb1e8ce81e9e78f7a0b1a15f9
https://doi.org/10.1007/s00253-019-09874-0
https://doi.org/10.1007/s00253-019-09874-0
Publikováno v:
ACS Synthetic Biology. 8:818-825
Monacolin J is a key precursor for the synthesis of the cholesterol-lowering drug simvastatin. Industrially, monacolin J is manufactured through the alkaline hydrolysis of the fungal polyketide lovastatin, which is relatively complex and environmenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318353fa41235b95b8702a5e18c03c65
https://doi.org/10.1021/acssynbio.8b00489
https://doi.org/10.1021/acssynbio.8b00489