Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mona Svensson"'
Autor:
Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J. Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 940-953 (2021)
Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). Th
Externí odkaz:
https://doaj.org/article/0b5582ac7f564cf380fe77d5fa6cd305
Autor:
Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 815-823 (2020)
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX)
Externí odkaz:
https://doaj.org/article/0f50faf3cf0e43df86dcdb218f2f2fdd
Autor:
Naresh Sunduru, Mona Svensson, Mariateresa Cipriano, Sania Marwaha, C. David Andersson, Richard Svensson, Christopher J. Fowler, Mikael Elofsson
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 513-521 (2017)
Fatty acid amide hydrolase (FAAH) is a promising target for the development of drugs to treat neurological diseases. In search of new FAAH inhibitors, we identified 2-(4-cyclohexylphenoxy)-N-(3-(oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide, 4g, with a
Externí odkaz:
https://doaj.org/article/56045177574f429a8dafbbdc15fb8d71
Autor:
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139212 (2015)
Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-N-(3-
Externí odkaz:
https://doaj.org/article/a62dbb4ce5a34f169230d3bb37502d5d
Autor:
Jessica Karlsson, Carmine M Morgillo, Alessandro Deplano, Giovanni Smaldone, Emilia Pedone, F Javier Luque, Mona Svensson, Ettore Novellino, Cenzo Congiu, Valentina Onnis, Bruno Catalanotti, Christopher J Fowler
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142711 (2015)
Combined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more potent inh
Externí odkaz:
https://doaj.org/article/7c0231800b9a4742aa904b05b0831370
Autor:
Alessandro, Deplano, Jessica, Karlsson, Federica, Moraca, Mona, Svensson, Claudia, Cristiano, Carmine Marco, Morgillo, Christopher J, Fowler, Roberto, Russo, Bruno, Catalanotti, Valentina, Onnis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). Th
Autor:
Jessica Karlsson, Federica Moraca, Valentina Onnis, Alessandro Deplano, Mona Svensson, Bruno Catalanotti, Roberto Russo, Claudia Cristiano, Christopher J. Fowler, Carmine Marco Morgillo
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 940-953 (2021)
Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd9c57faf1465449b805b98139ba456
http://hdl.handle.net/11588/874478
http://hdl.handle.net/11588/874478
Autor:
Mona Svensson, Jessica Karlsson, Valentina Onnis, Christopher J. Fowler, Bruno Catalanotti, Federica Moraca, Alessandro Deplano
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 815-823 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 815-823 (2020)
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db433c48ee7b9cb29a4650e89efaae9c
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174734
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174734
Autor:
Alessandro Deplano, Valentina Onnis, Monica Demurtas, Maria Grazia Cabiddu, Mona Svensson, Giovanni Smaldone, Ettore Novellino, Bruno Catalanotti, Emilia Pedone, Emmelie Björklund, Carmine Marco Morgillo, Sanaz Hashemian, Mariateresa Cipriano, Christopher J. Fowler, F. Javier Luque
Publikováno v:
European Journal of Medicinal Chemistry. 136:523-542
Fatty acid amide hydrolase (FAAH) has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol. FAAH inhibition represents a promising strategy to act
Autor:
Yuji Nagai, Neil Vasdev, Mona Svensson, Daisuke Ogasawara, Tomoteru Yamasaki, Masayuki Fujinaga, Yiding Zhang, Gengyang Yuan, Benjamin F. Cravatt, Zhen Chen, Ran Cheng, Yunfei Du, Mireille Alhouayek, Mary Jo Ondrechen, Ming-Rong Zhang, Takafumi Minamimoto, Wakana Mori, Longle Ma, Hang Shi, Xiaofei Zhang, Katsushi Kumata, Steven H. Liang, Christopher J. Fowler, Akiko Hatori, Lin Xie, Lu Wang
Monoacylglycerol lipase (MAGL) is the principle enzyme for metabolizing endogenous cannabinoid ligand 2-arachidonoyglycerol (2-AG). Blockade of MAGL increases 2-AG levels, resulting in subsequent activation of the endocannabinoid system, and has emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b109c1f89956051463ba6b486c4e0
https://europepmc.org/articles/PMC5966020/
https://europepmc.org/articles/PMC5966020/