Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mona Reichel"'
Autor:
Edda S. F. Matthees, Jenny C. Filor, Natasha Jaiswal, Mona Reichel, Noureldine Youssef, Giulia D’Uonnolo, Martyna Szpakowska, Julia Drube, Gabriele M. König, Evi Kostenis, Andy Chevigné, Amod Godbole, Carsten Hoffmann
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract G protein-coupled receptors (GPCRs) are mainly regulated by GPCR kinase (GRK) phosphorylation and subsequent β-arrestin recruitment. The ubiquitously expressed GRKs are classified into cytosolic GRK2/3 and membrane-tethered GRK5/6 subfamili
Externí odkaz:
https://doaj.org/article/96a45090aeee491db5f90c0458558dd1
Autor:
Raphael S. Haider, Edda S. F. Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells. These reveal that the same GPCR induces differential conformational rearrangements th
Externí odkaz:
https://doaj.org/article/c788b6ac74db47fe8176035c251fe6d0
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1195
G protein-coupled receptors (GPCRs) are regulated by GPCR kinases (GRKs) which phosphorylate intracellular domains of the active receptor. This results in the recruitment of arrestins, leading to desensitization and internalization of the GPCR. Aside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::37105054ba2489936ba3035cee94cac9