Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Mona O. Sarhan"'
1
Akademický článek
Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs
Autor: Xueyi Chen, Bhavatharini Arun, Oscar J. Nino-Meza, Mona O. Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth W. Tucker, Laurence S. Carroll, Joel S. Freundlich, Charles A. Peloquin, Vijay D. Ivaturi, Sanjay K. Jain
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration. Here, we perform first
Externí odkaz: https://doaj.org/article/12b747e27b024b34afbe5771b810380b
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2
Akademický článek
Tailoring of Selenium-Plated Novasomes for Fine-Tuning Pharmacokinetic and Tumor Uptake of Quercetin: In Vitro Optimization and In Vivo Radiobiodistribution Assessment in Ehrlich Tumor-Bearing Mice
Autor: Heba M. Aboud, Amal K. Hussein, Abdallah Z. Zayan, Tarek Saad Makram, Mona O. Sarhan, Dina M. El-Sharawy
Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 875 (2022)
Quercetin (QRC) is a bioflavonoid with anti-inflammatory, antioxidant, and anticancer activities, yet QRC poor bioavailability has hampered its clinical implementation. The aim of the current work was to harness novasomes (NOVs), free fatty acid enri
Externí odkaz: https://doaj.org/article/a0b2257d7c654755a7b1cef32a69cb53
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3
Akademický článek
Discovery of New Coumarin-Based Lead with Potential Anticancer, CDK4 Inhibition and Selective Radiotheranostic Effect: Synthesis, 2D & 3D QSAR, Molecular Dynamics, In Vitro Cytotoxicity, Radioiodination, and Biodistribution Studies
Autor: Mona O. Sarhan, Somaia S. Abd El-Karim, Manal M. Anwar, Raghda H. Gouda, Wafaa A. Zaghary, Mohammed A. Khedr
Publikováno v: Molecules, Vol 26, Iss 8, p 2273 (2021)
Novel 6-bromo-coumarin-ethylidene-hydrazonyl-thiazolyl and 6-bromo-coumarin-thiazolyl-based derivatives were synthesized. A quantitative structure activity relationship (QSAR) model with high predictive power r2 = 0.92, and RMSE = 0.44 predicted five
Externí odkaz: https://doaj.org/article/26be2dc592cf4a98a26c8592b0570102
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Plný text Recenzováno Digitální knihovna AV ČR
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