Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mona Motwani"'
Autor:
Mona Motwani, Jason McGowan, Jennifer Antonovitch, Kevin MingJie Gao, Zhaozhao Jiang, Shruti Sharma, Gretchen A. Baltus, Kevin M. Nickerson, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficienc
Externí odkaz:
https://doaj.org/article/fa75b31b38f0482698b841d9e116acff
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Roland Elling, Elektra K. Robinson, Barbara Shapleigh, Stephen C. Liapis, Sergio Covarrubias, Sol Katzman, Abigail F. Groff, Zhaozhao Jiang, Shiuli Agarwal, Mona Motwani, Jennie Chan, Shruti Sharma, Elizabeth J. Hennessy, Garret A. FitzGerald, Michael T. McManus, John L. Rinn, Katherine A. Fitzgerald, Susan Carpenter
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1511-1524.e6 (2018)
Summary: An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is
Externí odkaz:
https://doaj.org/article/9d6e33fd6acd48828a125c653a1219ae
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e66585 (2013)
P21-activated kinase 1 (PAK1), a serine/threonine protein kinase, modulates many cellular processes by phosphorylating its downstream substrates. In addition to its role in the cytoplasm, PAK1 also affects gene transcription due to its nuclear locali
Externí odkaz:
https://doaj.org/article/eedaba40a4b049639950e9333806755d
Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genes.
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36212 (2012)
N-linked glycosylation is one of the most frequent post-translational modifications of proteins with a profound impact on their biological function. Besides other functions, N-linked glycosylation assists in protein folding, determines protein orient
Externí odkaz:
https://doaj.org/article/da40f953626d4ed899d175b99d09eb46
Autor:
Kevin MingJie Gao, Mona Motwani, Thomas Tedder, Ann Marshak-Rothstein, Katherine A. Fitzgerald
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Pediatric patients with constitutively active mutations in the cytosolic double-stranded-DNA-sensing adaptor STING develop an autoinflammatory syndrome known as STING-associated vasculopathy with onset in infancy (SAVI). SAVI patients have elevated i
Publikováno v:
Nature Reviews Genetics. 20:657-674
The detection of pathogens through nucleic acid sensors is a defining principle of innate immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for foreign nucleic acids and, upon recognition, trigger immune signalling pathw
Autor:
M Marosfoi, Alexandra Weiss, Michael P. Moazami, Jonathan K. Watts, Katherine A. Fitzgerald, Pranathi Meda Krishnamurthy, Robert H. Brown, Julia M. Rembetsy-Brown, Robert M. King, Mona Motwani, Feng Wang, Heather L. Gray-Edwards
Antisense oligonucleotides (ASOs) are emerging as a promising class of therapeutics for neurological diseases. When injected directly into the cerebrospinal fluid, ASOs distribute broadly across brain regions and exert long-lasting therapeutic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5055b16e6679827ba7a000bb712ad720
https://doi.org/10.1101/2021.02.14.431096
https://doi.org/10.1101/2021.02.14.431096
Autor:
Gretchen A. Baltus, Ann Marshak-Rothstein, Jason D. McGowan, Zhaozhao Jiang, Shrutie Sharma, Mona Motwani, Kevin M. Nickerson, Jennifer Antonovitch, Katherine A. Fitzgerald, Kevin MingJie Gao
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Detection of DNA is an important determinant of host-defense but also a driver of autoinflammatory and autoimmune diseases. Failure to degrade self-DNA in DNAseII or III(TREX1)-deficient mice results in activation of the cGAS-STING pathway. Deficienc
Autor:
Ann Marshak-Rothstein, Katherine A. Fitzgerald, Terry Fang, Mona Motwani, Jennifer Bernier, Kate Henry, Sudesh Pawaria, Linda C. Burkly, Stephanie Moses
Studies over the past decade have revealed a central role for innate immune sensors in autoimmune and autoinflammatory diseases. cGAS, a cytosolic DNA sensor, detects both foreign and host DNA and generates a second-messenger cGAMP, which in turn bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb332b4bd2788b992dcf09e40282e48
https://europepmc.org/articles/PMC6475399/
https://europepmc.org/articles/PMC6475399/