Výsledky vyhledávání

In Silico Design and Experimental Validation of siRNAs Targeting Conserved Regions of Multiple Hepatitis C Virus Genotypes

Autor: Tae Kyu Kim, Marwa Amer, Mona Kamar, Saehong Min, Nafisa M. Hassan, Suher Zada, Marc P. Windisch, Mahmoud ElHefnawi, Eman El-Ahwany, Hee-Young Kim

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0159211 (2016)

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism that mediates the sequence-specific degradation of targeted RNA and thus provides a tremendous opportunity for development of oligonucleotide-based drugs. Here, we report on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c5f72b107f162a48f7ece409faba4a
https://pubmed.ncbi.nlm.nih.gov/27441640

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The design of optimal therapeutic small interfering RNA molecules targeting diverse strains of influenza A virus

Autor: Anna Lisa Remoli, Iman A. El-Azab, Giulia Marsili, Mona Kamar, Marco Sgarbanti, Osama AlAidy, Nafisa M. Hassan, Rania Siam, Mahmoud ElHefnawi

Publikováno v: Bioinformatics (Oxford, England). 27(24)

Motivation: There is an urgent need for new medications to combat influenza pandemics. Methods: Using the genome analysis of the influenza A virus performed previously, we designed and performed a combinatorial exhaustive systematic methodology for o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7684bacbd19cc62aa432c7e00f5aa1fa
https://pubmed.ncbi.nlm.nih.gov/21994230

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Identification of novel conserved functional motifs across most Influenza A viral strains

Autor: Iman A. El-Azab, Osama Alaidi, Mona Kamar, Suher Zada, Rania Siam, Mahmoud ElHefnawi, Nafisa Mohamed

Publikováno v: Virology Journal, Vol 8, Iss 1, p 44 (2011)
Virology Journal

Background Influenza A virus poses a continuous threat to global public health. Design of novel universal drugs and vaccine requires a careful analysis of different strains of Influenza A viral genome from diverse hosts and subtypes. We performed a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92716518d3cc5a5e6acbcb001901aa0
http://www.virologyj.com/content/8/1/44

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