Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mona Kalmouni"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 11, p 1443 (2024)
Peptides possess a number of pharmacologically desirable properties, including greater chemical diversity than other biomolecule classes and the ability to selectively bind to specific targets with high potency, as well as biocompatibility, biodegrad
Externí odkaz:
https://doaj.org/article/e40427d75b2e4ecb87a79098cdd7bf56
Autor:
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell prol
Externí odkaz:
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Autor:
Sudhir Kumar Sharma, Sumaya Al Hosani, Mona Kalmouni, Anjana Ramdas Nair, Loganathan Palanikumar, Renu Pasricha, Kirsten C. Sadler, Mazin Magzoub, Ramesh Jagannathan
Publikováno v:
ACS Omega, Vol 5, Iss 9, Pp 4558-4567 (2020)
Externí odkaz:
https://doaj.org/article/c7eaf05c39bb44bcab799d50b58a1acb
Autor:
L. Palanikumar, Mona Kalmouni, Tatiana Houhou, Osama Abdullah, Liaqat Ali, Renu Pasricha, Sneha Thomas, Ahmed J. Afzal, Francisco N. Barrera, Mazin Magzoub
Publikováno v:
bioRxiv
Photodynamic therapy (PDT) and photothermal therapy (PTT) have garnered considerable interest as non-invasive cancer treatment modalities. However, these approaches remain limited by low solubility, poor stability and inefficient targeting of many co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd888381651ca6b38dca29e06aa9eef
https://doi.org/10.1101/2023.05.22.541491
https://doi.org/10.1101/2023.05.22.541491
Autor:
Laura Karpauskaite, Ahmed J. Afzal, Ibrahim Chehade, Jemil Ahmed, Renu Pasricha, Mazin Magzoub, Andrew D. Hamilton, Debabrata Maity, Mona Kalmouni, Loganathan Palanikumar, Sunil Kumar, Maheen Alam, Tatiana Houhou, Gennaro Esposito, Zackary Falls, Shake Karapetyan, Yamanappa Hunashal, Ram Samudrala, Mohamed Al-Sayegh, Liaqat Ali, Sarah Hassan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Nature Communications
Nature Communications
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expose it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914b9d23167b4db0a4609f8d776a3030
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Publikováno v:
Biochemistry. 59:2259-2273
Cancer cells are often characterized by elevated levels of mitochondrion-bound hexokinase II (HKII), which facilitates their survival, proliferation, and metastasis. Here, we have designed a cancer-selective cell-penetrating peptide (CPP) by covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72350928acd31cf76a394d5a3e19b673
https://doi.org/10.1021/acs.biochem.0c00141
https://doi.org/10.1021/acs.biochem.0c00141
Autor:
Kirsten C. Sadler, Loganathan Palanikumar, Seema Sharma, Anjana Ramdas Nair, Sumaya Al Hosani, Ramesh Jagannathan, Mona Kalmouni, Mazin Magzoub, Renu Pasricha
Publikováno v:
ACS Omega, Vol 5, Iss 9, Pp 4558-4567 (2020)
Cisplatin is a highly toxic material used clinically as a potent chemotherapeutic. While effective against some cancers, toxicity limits widespread use and low solubility confounds delivery. To formulate a better tolerated and more water-soluble form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2cbe9b7c0fc638d5bbaf51977c65c3
https://doaj.org/article/c7eaf05c39bb44bcab799d50b58a1acb
https://doaj.org/article/c7eaf05c39bb44bcab799d50b58a1acb
Autor:
Mazin Magzoub, Sarah Hassan, Maheen Alam, Yamanappa Hunashal, Gennaro Esposito, Mohamed Al-Sayegh, Ibrahim Chehade, Liaqat Ali, Zackary Falls, Andrew D. Hamilton, Renu Pasricha, Sunil Kumar, Laura Karpauskaite, Ahmed J. Afzal, Mona Kalmouni, Jemil Ahmed, Ram Samudrala, Debabrata Maity, Loganathan Palanikumar, Shake Karapetyan
Missense mutations in p53 are severely deleterious and occur in over 50% of all human cancers. The vast majority of these mutations are located in the inherently unstable DNA-binding domain (DBD), many of which destabilize the domain further and expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa961805711ad26790abd3b96f53b97
https://doi.org/10.1101/2020.08.10.243154
https://doi.org/10.1101/2020.08.10.243154
Autor:
Palanikumar Loganathan, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Ali, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Tatiana Houhou, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Biophysical Journal. 121:300a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe04b24e5b092891b3c7e61f9e1fc2ce
https://doi.org/10.1016/j.bpj.2021.11.1253
https://doi.org/10.1016/j.bpj.2021.11.1253
Autor:
Sudhir Kumar, Sharma, Sumaya, Al Hosani, Mona, Kalmouni, Anjana Ramdas, Nair, Loganathan, Palanikumar, Renu, Pasricha, Kirsten C, Sadler, Mazin, Magzoub, Ramesh, Jagannathan
Publikováno v:
ACS Omega
Cisplatin is a highly toxic material used clinically as a potent chemotherapeutic. While effective against some cancers, toxicity limits widespread use and low solubility confounds delivery. To formulate a better tolerated and more water-soluble form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b77c8583f8e82ecc717e0ebea18c4bc
https://pubmed.ncbi.nlm.nih.gov/32175502
https://pubmed.ncbi.nlm.nih.gov/32175502