Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mona Hoseini Soflaee"'
Autor:
Mona Hoseini Soflaee, Rushendhiran Kesavan, Umakant Sahu, Alpaslan Tasdogan, Elodie Villa, Zied Djabari, Feng Cai, Diem H. Tran, Hieu S. Vu, Eunus S. Ali, Halie Rion, Brendan P. O’Hara, Sherwin Kelekar, James Hughes Hallett, Misty Martin, Thomas P. Mathews, Peng Gao, John M. Asara, Brendan D. Manning, Issam Ben-Sahra, Gerta Hoxhaj
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces s
Externí odkaz:
https://doaj.org/article/e65828f4fe7b450899c62fcdaa40754f
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Genetically encoded, Förster resonance energy transfer (FRET) biosensors enable live-cell optical imaging of signaling molecules. Small conformational changes often limit the dynamic range of biosensors that combine fluorescent proteins (FP
Externí odkaz:
https://doaj.org/article/2d7f8e26831048bfbb6bfd92a1762bb0
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 6, Pp 945-952 (2020)
Lipid kinases and phosphatases play key roles in cell signaling and regulation, are implicated in many human diseases, and are thus attractive targets for drug development. Currently, no direct in vitro activity assay is available for these important
Externí odkaz:
https://doaj.org/article/8df42892778b48d8b3a475499dd94984
Autor:
Halie Rion, Ralph J. DeBerardinis, Diem Hong Tran, Mona Hoseini Soflaee, Rushendhiran Kesavan, Hieu Sy Vu, John A. Phillips, Divya Bezwada, Gerta Hoxhaj, Feng Cai, Ashley Solmonson
Publikováno v:
Nature Metabolism. 3:571-585
Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress. NADPH exists in separate pools, in both the cytosol and
Autor:
Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G. Zacharias, Thomas P. Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj
Publikováno v:
Molecular Cell
Molecular Cell, In press, 82 (17), pp.3299-3311.e8. ⟨10.1016/j.molcel.2022.06.026⟩
Molecular Cell, In press, 82 (17), pp.3299-3311.e8. ⟨10.1016/j.molcel.2022.06.026⟩
Submitted document; International audience; NAD+ kinases (NADKs) are metabolite kinases that phosphorylate NAD+ molecules to make NADP+, a limiting substrate for the generation of reducing power NADPH. NADK2 sustains mitochondrial NADPH production th
Autor:
Diem H, Tran, Rushendhiran, Kesavan, Halie, Rion, Mona Hoseini, Soflaee, Ashley, Solmonson, Divya, Bezwada, Hieu S, Vu, Feng, Cai, John A, Phillips, Ralph J, DeBerardinis, Gerta, Hoxhaj
Publikováno v:
Nat Metab
Nicotinamide adenine dinucleotide phosphate (NADP(+)) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress. NADPH exists in separate pools, in both the cytosol an
Publikováno v:
Analyst
We report a label-free nanopore sensor for the detection of Zn(2+) ion. By taking advantage of the cleavage of a substrate peptide by zinc dependent enzyme, nanomolar concentrations of Zn(2+) ion could be detected within minutes. Furthermore, structu