Výsledky vyhledávání - "Mona Elgazzaz"

Akademický článek

Maternal Western diet programs cardiometabolic dysfunction and hypothalamic inflammation via epigenetic mechanisms predominantly in the male offspring

Autor: Mona Elgazzaz, Clara Berdasco, Jone Garai, Melody Baddoo, Shiping Lu, Hisham Daoud, Jovanny Zabaleta, Franck Mauvais-Jarvis, Eric Lazartigues

Publikováno v: Molecular Metabolism, Vol 80, Iss , Pp 101864- (2024)

Objective: Maternal exposure during pregnancy is a strong determinant of offspring health outcomes. Such exposure induces changes in the offspring epigenome resulting in gene expression and functional changes. In this study, we investigated the effec

Externí odkaz: https://doaj.org/article/6489b879ed3342e9a6f9cdf90331e953

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Nedd4-2 up-regulation is associated with ACE2 ubiquitination in hypertension

Autor: Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A Mendiola Plá, Dawn E Bowles, Andreas M Beyer, Xinping Yue, Eric Lazartigues, Catalin M Filipeanu

Publikováno v: Cardiovascular Research.

Aims Angiotensin-converting enzyme 2 (ACE2) is a critical component of the compensatory renin–angiotensin system that is down-regulated during the development of hypertension, possibly via ubiquitination. However, little is known about the mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26d6a6e936df1e86cc0cfcfa56418ebc
https://doi.org/10.1093/cvr/cvad070

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UBR1 Mediates ACE2 Ubiquitination and Hypertension in Male Mice

Autor: Mona Elgazzaz, Anna Nuzzo, Luke Restivo, Kevin Miao, Eric Lazartigues

Publikováno v: Physiology. 38

Angiotensin-II is one of the main players in the renin angiotensin system (RAS). It mediates vasoconstriction and inflammation through binding to angiotensin-II receptor 1 (AT1R). Conversely, angiotensin converting enzyme 2 (ACE2) counteracts the vas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18d3f15c3989aa3eedbe961594765e0a
https://doi.org/10.1152/physiol.2023.38.s1.5724799

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Abstract 058: ACE2 Ubiquitination Regulates Neuronal Activity In Hypertension

Autor: Mazher Mohammed, Mona Elgazzaz, Xinping Yue, Catalin Filipeanu, Eric D Lazartigues

Publikováno v: Hypertension. 79

ACE2 expression on GABAergic neurons could maintain the inhibitory tone over pre-sympathetic neurons in the paraventricular nucleus (PVN) and thus contribute to the regulation of blood pressure (BP). Here we investigated the role of ACE2 ubiquitinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faeda7f64dac3457a6b0f7f7c4b73475
https://doi.org/10.1161/hyp.79.suppl_1.058

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158-OR: Perinatal Hypercaloric Diet Leads to Cardiometabolic Imbalance via Hypothalamic Methylation Events in Male Mice

Autor: MONA ELGAZZAZ, CLARA BERDASCO, ERIC D. LAZARTIGUES

Publikováno v: Diabetes. 71

Cardiometabolic diseases are among the highest prevalent diseases worldwide. We have reported that perinatal maternal programming through hypercaloric diet (HCD) leads to an elevation in systolic BP and blood glucose levels exclusively in male mice o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb5ea9a3701407fc8566814a814df45c
https://doi.org/10.2337/db22-158-or

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Epigenetic modifications of the renin–angiotensin system in cardiometabolic diseases

Autor: Mona Elgazzaz, Eric Lazartigues

Publikováno v: Clinical Science. 135:127-142

Cardiometabolic diseases (CMDs) are among the most prevalent and the highest mortality diseases. Single disease etiology such as gene mutation, polymorphisms, or environmental exposure has failed to explain the origin of CMD. This can be evident in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99de85b9b708025b6339ba417e194ce
https://doi.org/10.1042/cs20201287

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ACE2 Ubiquitination in the Paraventricular Nucleus of the Hypothalamus Contributes to Angiotensin‐II‐Induced Hypertension in Mice

Autor: Mazher Mohammed, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Md Abdul Awoal, Parnia Mobasheran, Catalin Filipeanu, Eric Lazartigues

Publikováno v: The FASEB Journal. 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5ce3dfbc6a2d0e8f3129d2b8d951946
https://doi.org/10.1096/fasebj.2022.36.s1.r4386

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Abstract MP57: Chronic Inhibition Of Brain Rhomboid-like Protein 2 (irhom2) Activity Decreases Arterial Blood Pressure In Salt-sensitive Hypertension In Mice

Autor: Eric Lazartigues, Mazher Mohammed, Clara Berdasco, Mona Elgazzaz

Publikováno v: Hypertension. 78

We previously reported that ADAM17 (aka tumor necrosis factor-α convertase) is critical for the development of hypertension in experimental models and patients. Recent studies highlighted that ADAM17’s formation of TNF-α relies on prior maturatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::076225116b00d0ce41bbaf02504c0d54
https://doi.org/10.1161/hyp.78.suppl_1.mp57

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172-OR: Perinatal Exposure to a Western Diet Alters Hypothalamic Gene Expression and Predisposes to Diabetes in Adult Male Mice

Autor: Eric Lazartigues, Franck Mauvais-Jarvis, Mona Elgazzaz

Publikováno v: Diabetes. 70

Cardiometabolic diseases are among the most prevalent diseases worldwide. Maternal epigenetic imprinting affects gene expression in offspring, leading to increased disease susceptibility later in life. We showed previously that perinatal exposure to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de7dd58c702104540e1b40f2a9a5fdc
https://doi.org/10.2337/db21-172-or

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