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pro vyhledávání: '"Mona D, Lee"'
Autor:
Mona D, Lee, Yuhong, She, Michael J, Soskis, Christopher P, Borella, Jeffrey R, Gardner, Paula A, Hayes, Benzon M, Dy, Mark L, Heaney, Mark R, Philips, William G, Bornmann, Francis M, Sirotnak, David A, Scheinberg
Publikováno v:
Journal of Clinical Investigation. 114:1107-1116
Peptide deformylase activity was thought to be limited to ribosomal protein synthesis in prokaryotes, where new peptides are initiated with an N-formylated methionine. We describe here a new human peptide deformylase (Homo sapiens PDF, or HsPDF) that
Autor:
Francis M. Sirotnak, David A. Scheinberg, Christophe Antczak, William Bornmann, Mona D Lee, Yue-Ming Li
Publikováno v:
Biochemical and biophysical research communications. 312(2)
Peptide deformylases (PDFs) have been investigated as potential specific targets for antibiotics, but the possible existence of a functional human PDF (HsPDF) presents a potential hurdle to the design of specific drugs. We have expression cloned a Hs