Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mona Al-Mugotir"'
Autor:
Mona Al-Mugotir, Jeffrey J Lovelace, Joseph George, Mika Bessho, Dhananjaya Pal, Lucas Struble, Carol Kolar, Sandeep Rana, Amarnath Natarajan, Tadayoshi Bessho, Gloria E O Borgstahl
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248941 (2021)
Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics against cancer cells. Inactivation of RAD52 is synthetically lethal to homologous recombination (HR) deficient cancer cell lines. Replication protein A (RPA)
Externí odkaz:
https://doaj.org/article/61c7e66c5d784f338511623f59b276e2
Autor:
Carol Kolar, Gloria E. O. Borgstahl, Mona Al-Mugotir, Amarnath Natarajan, Krysten E. Vance, David Lee Kelly
Publikováno v:
Anal Biochem
Due to the therapeutic potential of targeting protein-protein interactions (PPIs) there is a need for easily executed assays to perform high throughput screening (HTS) of inhibitors. We have developed and optimized an innovative and robust fluorescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba7597a2cf9ccfe6f983d7a264f145c
https://doi.org/10.1016/j.ab.2019.01.010
https://doi.org/10.1016/j.ab.2019.01.010
Autor:
Dhananjaya Pal, Mika Bessho, Joseph W. George, Gloria E. O. Borgstahl, Tadayoshi Bessho, Lucas R. Struble, Sandeep Rana, Jeffrey J. Lovelace, Mona Al-Mugotir, Carol Kolar, Amarnath Natarajan
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248941 (2021)
PLoS ONE
PLoS ONE
Synthetic lethality is a successful strategy employed to develop selective chemotherapeutics against cancer cells. Inactivation of RAD52 is synthetically lethal to homologous recombination (HR) deficient cancer cell lines. Replication protein A (RPA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c624fd19c4fc13767612c84f47b8a4
https://doaj.org/article/61c7e66c5d784f338511623f59b276e2
https://doaj.org/article/61c7e66c5d784f338511623f59b276e2
Autor:
Amaranth Natarajan, Gloria E. O. Borgstahl, Mona Al-Mugotir, David Lee Kelly, Carol Kolar, Tadayoshi Bessho
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9ce08af949fa43a784cb28dd9b618fd
https://doi.org/10.1096/fasebj.2020.34.s1.00544
https://doi.org/10.1096/fasebj.2020.34.s1.00544
Autor:
Sydney Zach, Rosslyn Grosely, Gaelle Spagnol, Fabien Kieken, Mona Al-Mugotir, Sarah Nabors, Paul L. Sorgen, Jennifer L. Kopanic
Publikováno v:
Journal of Biological Chemistry. 288:24857-24870
Phosphorylation of the connexin43 C-terminal (Cx43CT) domain regulates gap junction intercellular communication. However, an understanding of the mechanisms by which phosphorylation exerts its effects is lacking. Here, we test the hypothesis that pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9a66f6b28edcf63ca57793307952b2
https://doi.org/10.1074/jbc.m113.454389
https://doi.org/10.1074/jbc.m113.454389
Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifyingGolgi/post-Golgi compartments
Autor:
Paul L. Sorgen, Satyanarayana Rachagani, Srustidhar Das, Mona Al-Mugotir, Surinder K. Batra, Prabin D. Majhi
Publikováno v:
Scientific Reports
MUC16, precursor of the most widely used ovarian cancer biomarker CA125, is upregulated in multiple malignancies and is associated with poor prognosis. While thepro-tumorigenic and metastatic roles of MUC16 are ascribed to the cell-associatedcarboxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc96ed57a2bb4ec197fd732d9920c4a3
https://doi.org/10.1038/srep09759
https://doi.org/10.1038/srep09759
Autor:
Stephen I. Rennard, Xiangde Liu, Qiuhong Fang, Mona Al-Mugotir, Tetsu Kobayashi, Shinji Abe, Tadashi Kohyama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 35:714-721
Degradation of preexisting and newly synthesized extracellular matrix is thought to play an important role in tissue remodeling. The current study evaluated whether thrombin and TNF-alpha/IL-1beta could collaboratively induce collagen degradation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02eb8cbfede8fa9cb0a63785d91f1a4b
https://doi.org/10.1165/rcmb.2005-0026oc
https://doi.org/10.1165/rcmb.2005-0026oc
Autor:
Mona Al-Mugotir, Rosslyn Grosely, Jennifer L. Kopanic, Paul L. Sorgen, Srustidhar Das, Sydney Zach
Publikováno v:
Frontiers in Pharmacology, Vol 4 (2013)
Frontiers in Pharmacology
Frontiers in Pharmacology
A major problem for structural characterization of membrane proteins, such as connexins, by nuclear magnetic resonance (NMR) occurs at the initial step of the process, the production of sufficient amounts of protein. This occurs because proteins must
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db0bc401113564928b29a9150007e76
http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00106/full
http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00106/full
Autor:
Jennifer L. Kopanic, Paul L. Sorgen, Andrew J. Trease, Mona Al-Mugotir, Sydney Zach, Fabien Kieken
Publikováno v:
Biophysical Journal. (10):2184-2195
Mechanisms underlying the initiation and persistence of lethal cardiac rhythms are of significant clinical and scientific interests. Gap junctions are principally involved in forming the electrical connections between myocytes, and changes in distrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c155224a7e9c7efcc083daf97a71d6
Autor:
Xingqi Wang, Qiu Hong Fang, Peter B. Bitterman, Huijung Kim, Xiangde Liu, Mona Al-Mugotir, Tetsu Kobayashi, Lijun Mao, Shinsaku Togo, Stephen I. Rennard
Publikováno v:
Respiratory Research, Vol 9, Iss 1, p 66 (2008)
Respiratory Research
Respiratory Research
Background We have previously reported that low concentrations of cigarette smoke extract induce DNA damage without leading to apoptosis or necrosis in human bronchial epithelial cells (HBECs), and that IL-6/STAT3 signaling contributes to the cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91cd9bf6b4a9ba895073e9f79689d8c