Comparison of an in-house 'home-brew' and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples.

Autor: Kaelo K Seatla, Wonderful T Choga, Mompati Mogwele, Thabo Diphoko, Dorcas Maruapula, Lucy Mupfumi, Rosemary M Musonda, Christopher F Rowley, Ava Avalos, Ishmael Kasvosve, Sikhulile Moyo, Simani Gaseitsiwe

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0224292 (2019)

BackgroundRoll-out of Integrase Strand Transfer Inhibitors (INSTIs) such as dolutegravir for HIV combination antiretroviral therapy (cART) in sub-Saharan Africa necessitates the development of affordable HIV drug resistance (HIVDR) assays targeting t

Externí odkaz: https://doaj.org/article/563981b73ee344e398ad6377ba952991

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana

Autor: Tshenolo Ntsipe, Mompati Mogwele, Kaelo K Seatla, Simani Gaseitsiwe, Madisa Mine, Ishmael Kasvosve, Sikhulile Moyo, Joseph Makhema, Bornapate Nkomo, Shahin Lockman, Dinah Ramaabya, Wonderful T. Choga, Max Kapanda, Dorcas Maruapula, Nametso Mathiba, Mompati Mmalane

Publikováno v: Viruses
Volume 13
Issue 4
Viruses, Vol 13, Iss 594, p 594 (2021)

There are limited real-world mutational and virological outcomes data of treatment-experienced persons diagnosed with HIV-1 subtype C (HIV-1 C) who are failing Integrase Strand Transfer Inhibitor-based regimens. Requisition forms sent for HIV-1 genot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f859bfff9b1f64289326abb50641b0

Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana

Autor: Thomas S. Harrison, Joseph N Jarvis, Natasha O. Moraka, Rosemary Musonda, Simani Gaseitsiwe, Kwana Lechiile, Ishmael Kasvosve, Mompati Mogwele, Dorcas Maruapula, Kesaobaka Molebatsi, Tshepo B Leeme, David S Lawrence, Sikhulile Moyo, Kaelo K Seatla, Nametso Kelentse, Lerato Esele

Publikováno v: Medicine

To determine effects of cryptococcal meningitis (CM) on human immunodeficiency virus (HIV)-1C cerebrospinal fluid (CSF) viral escape, CSF/plasma viral discordance, and drug resistance mutation (DRM) discordance between CSF and plasma compartments, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578be15c77a19f4d0fa10c3ffc2c5581
https://pubmed.ncbi.nlm.nih.gov/33031315

Comparison of an in-house 'home-brew' and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples.

Autor: Seatla, Kaelo K.^1,2 (AUTHOR), Choga, Wonderful T.³ (AUTHOR), Mogwele, Mompati^1,2 (AUTHOR), Diphoko, Thabo^1,2 (AUTHOR), Maruapula, Dorcas^1,2 (AUTHOR), Mupfumi, Lucy^1,2 (AUTHOR), Musonda, Rosemary M.^1,4 (AUTHOR), Rowley, Christopher F.⁴ (AUTHOR), Avalos, Ava^1,5,6 (AUTHOR), Kasvosve, Ishmael² (AUTHOR), Moyo, Sikhulile^1,4 (AUTHOR), Gaseitsiwe, Simani^1,4 (AUTHOR) sgaseitsiwe@gmail.com

Publikováno v: PLoS ONE. 11/21/2019, Vol. 14 Issue 11, p1-14. 14p.

HIV-1 Subtype C Drug Resistance Mutations in Heavily Treated Patients Failing Integrase Strand Transfer Inhibitor-Based Regimens in Botswana †.

Autor: Seatla, Kaelo K.^1,2 (AUTHOR) dmaruapula@gmail.com, Maruapula, Dorcas^1,2 (AUTHOR) wchoga@bhp.org.bw, Choga, Wonderful T.^1,3 (AUTHOR) nmathiba@bhp.org.bw, Ntsipe, Tshenolo⁴ (AUTHOR) tntsipe@bhp.org.bw, Mathiba, Nametso¹ (AUTHOR) mogwelem@yahoo.com, Mogwele, Mompati¹ (AUTHOR) jmakhema@bhp.org.bw, Kapanda, Max⁵ (AUTHOR) maxkapanda@gmail.com, Nkomo, Bornapate⁵ (AUTHOR) bnkomo@gov.bw, Ramaabya, Dinah⁵ (AUTHOR) dramaabya@gov.bw, Makhema, Joseph¹ (AUTHOR) mmmalane@bhp.org.bw, Mmalane, Mompati¹ (AUTHOR) shahin.lockman@gmail.com, Mine, Madisa⁴ (AUTHOR) madisamine0@gmail.com, Kasvosve, Ishmael² (AUTHOR), Lockman, Shahin^1,6,7 (AUTHOR) smoyo@bhp.org.bw, Moyo, Sikhulile^1,7 (AUTHOR) sgaseitsiwe@gmail.com, Gaseitsiwe, Simani^1,7 (AUTHOR), Grevenynghe, Julien Van (AUTHOR)

Publikováno v: Viruses (1999-4915). Apr2021, Vol. 13 Issue 4, p594. 1p.