Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Momoko Ohori"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, including development of multiple diseases. In particular, alternative splicing is profoundly involved in cancer progression thro
Externí odkaz:
https://doaj.org/article/c21bb2b1bacd4e879afd3fc7e4a56305
Autor:
Momoko Ohori, Yusuke Nakayama, Mari Ogasawara-Shimizu, Hiroyoshi Toyoshiba, Atsushi Nakanishi, Samuel Aparicio, Shinsuke Araki
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory network, including genome
Externí odkaz:
https://doaj.org/article/8a3ccdb38a2246d8b51530ba78db631f
Autor:
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
The phosphorylation of serine/arginine-rich proteins by CDC-like kinase is a central regulatory mechanism for RNA splicing reactions. Here, the authors synthesize a novel small molecule CLK inhibitor and map CLK-responsive alternative splicing events
Externí odkaz:
https://doaj.org/article/5aad2179e7e647afa20357dc81dea1bc
Autor:
Akihiro Ohashi, Momoko Ohori, Kenichi Iwai, Tadahiro Nambu, Maki Miyamoto, Tomohiro Kawamoto, Masanori Okaniwa
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144675 (2015)
Centromere-associated protein E (CENP-E) regulates both chromosome congression and the spindle assembly checkpoint (SAC) during mitosis. The loss of CENP-E function causes chromosome misalignment, leading to SAC activation and apoptosis during prolon
Externí odkaz:
https://doaj.org/article/da42cd14ef954614b2ceb184d31e0661
Autor:
Toshio Tanaka, Tomohiro Kawamoto, Satoshi Endo, Samuel Aparicio, Michiko Tawada, Atsushi Nakanishi, Momoko Ohori, Douglas R. Cary, Masahiro Ito, Masahiro Nogami, Toshihiro Imaeda, Misa Iwatani, Shinsuke Araki, Shoichi Nakao, Yasuhiro Imaeda
Publikováno v:
Biochemical and Biophysical Research Communications. 523:795-801
The DEAD-box family of RNA helicases plays essential roles in both transcriptional and translational mRNA degradation; they unwind short double-stranded RNA by breaking the RNA-RNA interactions. Two DEAD-box RNA helicases, eukaryotic translation init
Autor:
Toshiyuki Nomura, Hiroshi Sugimoto, Noriko Uchiyama, Akihiro Ohashi, Hideto Hara, Takashi Imada, Yukiko Yamamoto, Isaac Hoffman, Kenichi Iwai, Momoko Ohori, Misaki Homma, Osamu Kurasawa, Nobuo Cho, Tohru Miyazaki, Yuya Oguro, Kentaro Iwata, Robert J. Skene
Publikováno v:
Journal of Medicinal Chemistry. 63:1084-1104
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2-d]pyrimidinone analogue I showing time-dependent Cdc7 kinase inhibition and slow dissociation kinetics
Autor:
Samuel Aparicio, Hiroyoshi Toyoshiba, Yusuke Nakayama, Atsushi Nakanishi, Momoko Ohori, Mari Ogasawara-Shimizu, Shinsuke Araki
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Background Endothelial cell senescence is the state of permanent cell cycle arrest and plays a critical role in the pathogenesis of age-related diseases. However, a comprehensive understanding of the gene regulatory network, including genome-wide alt
Autor:
Ali Bashashati, Shinsuke Araki, Atsushi Nakanishi, Poul H. Sorensen, Damian Yap, Alborz Mazloomian, Amal El-Naggar, Samuel Aparicio, Momoko Ohori, Shoichi Nakao, Sohrab P. Shah
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-15 (2019)
Communications Biology
Communications Biology
The RNA helicase EIF4A3 regulates the exon junction complex and nonsense-mediated mRNA decay functions in RNA transcript processing. However, a transcriptome-wide network definition of these functions has been lacking, in part due to the lack of suit
Autor:
Momoko Ohori, Etsurou Watanabe, Tsuyoshi Ishi, Jason Yano, Shigeru Kondo, Shinji Fujimoto, Maki Miyamoto, Masato Yoshikawa, Toshiya Nishi, Takanobu Kuroita, Sayuri Watanabe, Haruhi Kamisaki Ando, Eiji Sunahara, William Farnaby, Shigeo Hasegawa, Shinichi Kondo, Tatsuki Koike, Matthew J. During
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S-hydroxycholesterol, the primary mechanism of cholesterol catabolism in the brain. The therapeutic potential of CH24H activation has been extensively inve
Autor:
Paola Nicoletti, Hisashi Anayama, Yasunori Nio, Yui Noguchi, Paul B. Watkins, Takanori Takebe, Momoko Ohori, Eri Kawakami, Guruprasad P. Aithal, Masaru Koido, Tadahiro Shinozawa, Junko Fukumura, Ann K. Daly, Yvonne P. Dragan
Publikováno v:
Nat Med
Drug-induced liver injury (DILI) is a leading cause of termination in drug development programs and removal of drugs from the market; this is partially due to the inability to identify patients who are at risk1. In this study, we developed a polygeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e2931a5dda5b2e2f7d2b4a5e3b0f9a
https://europepmc.org/articles/PMC8482794/
https://europepmc.org/articles/PMC8482794/