Výsledky vyhledávání - "Momoe Kassai"

Akademický článek

The Impact of Intestinal Microbiota and Toll-like Receptor 2 Signaling on α-Synuclein Pathology in Nontransgenic Mice Injected with α-Synuclein Preformed Fibrils

Autor: Yukako Koyanagi, Momoe Kassai, Hiroshi Yoneyama

Publikováno v: Microorganisms, Vol 12, Iss 1, p 106 (2024)

Intestinal microbiota and Toll-like receptor 2 (TLR2), which can bind lipoteichoic acid produced by microbiota, might contribute to the pathogenesis of Parkinson’s disease (PD), which is characterized by α-synuclein accumulation. Although the cont

Externí odkaz: https://doaj.org/article/f0b8d99a5f99414b83c7ee6138411af2

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Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor

Autor: Yoshie Nakatsuji, Hidenori Kimura, Yoko Deai, Katsunori Tsuboi, Yoshiaki Isobe, Momoe Kassai

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 44:128115

Kynurenine monooxygenase (KMO) is expected to be a good drug target to treat Huntington's disease (HD). This study presents the structure-activity relationship of pyridazine derivatives to find novel KMO inhibitors. The most promising compound 14 res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375ddeb5768db8eed4d7c0bd60b226ef
https://doi.org/10.1016/j.bmcl.2021.128115

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N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors

Autor: Mari Miyajima, Mika Endo, Yoko Deai, Momoe Kassai, Hitoshi Suda, Masahiro Yahata, Yoshiaki Isobe, Hidenori Kimura

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 33:127753

Huntington's disease (HD) is one of the serious neurodegenerative diseases and no disease modifiers are available to date. The correction of unbalanced kynurenine pathway metabolites may be useful to treat disease progression and kynurenine monooxyge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dfaa8c8e5fb195414e5d61a2dbd507
https://doi.org/10.1016/j.bmcl.2020.127753

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Synthesis, structure-activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators

Autor: Momoe Kassai, Makoto Takata, Wataru Hirose, Kohzo Yoshida, Satoki Imai, Takayoshi Yamamoto, Shun Hayashi, Yukiyo Arai, Yoshihiro Kato

Publikováno v: Bioorganicmedicinal chemistry letters. 26(16)

The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50=477nM), opt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e88d41a2a66ab3df07487247a3d766e
https://pubmed.ncbi.nlm.nih.gov/27432763

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