Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Momo Morikawa"'
Autor:
Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto‐Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Yui Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-24 (2019)
Abstract Mice with the C3H background show greater behavioral propensity for schizophrenia, including lower prepulse inhibition (PPI), than C57BL/6 (B6) mice. To characterize as‐yet‐unknown pathophysiologies of schizophrenia, we undertook proteom
Externí odkaz:
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4
Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport
Autor:
Shogo Yoshihara, Xuguang Jiang, Momo Morikawa, Tadayuki Ogawa, Sotaro Ichinose, Hirooki Yabe, Akiyoshi Kakita, Manabu Toyoshima, Yasuto Kunii, Takeo Yoshikawa, Yosuke Tanaka, Nobutaka Hirokawa
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108971- (2021)
Summary: In schizophrenia (SCZ), neurons in the brain tend to undergo gross morphological changes, but the related molecular mechanism remains largely elusive. Using Kif3b+/− mice as a model with SCZ-like behaviors, we found that a high-betaine die
Externí odkaz:
https://doaj.org/article/4c9b7e9f217844439440e312b6372119
Autor:
Li Wang, Yosuke Tanaka, Doudou Wang, Momo Morikawa, Ruyun Zhou, Noriko Homma, Yuki Miyamoto, Nobutaka Hirokawa
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2894-2907 (2018)
Summary: Kinesin superfamily proteins (KIFs) are molecular motors that typically alter the subcellular localization of their cargos. However, the atypical kinesin KIF26A does not serve as a motor but can bind microtubules and affect cellular signalin
Externí odkaz:
https://doaj.org/article/c2489c1d84be41be9130f4058ae0c3c0
Publikováno v:
Cell Reports, Vol 23, Iss 13, Pp 3864-3877 (2018)
Summary: Fear extinction is a component of cognitive flexibility that is relevant for important psychiatric diseases, but its molecular mechanism is still largely elusive. We established mice lacking the kinesin-4 motor KIF21B as a model for fear ext
Externí odkaz:
https://doaj.org/article/3b823488424c4d56980ffba986a7adb2
Autor:
Yuansong, Wan, Momo, Morikawa, Manatsu, Morikawa, Suguru, Iwata, Muhammad Imran, Naseer, Adeel Gulzar, Ahmed Chaudhary, Yosuke, Tanaka, Nobutaka, Hirokawa
Publikováno v:
The Journal of cell biology. 222(2)
Epilepsy is a common neurological disease worldwide, and one of its causes is genetic abnormalities. Here, we identified a point mutation in KIF4A, a member of kinesin superfamily molecular motors, in patients with neurological disorders such as epil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bf10145cba2f4f0be0deaa47cb750dc
https://pubmed.ncbi.nlm.nih.gov/36482480
https://pubmed.ncbi.nlm.nih.gov/36482480
Autor:
Manatsu Morikawa, Nivedita U Jerath, Tadayuki Ogawa, Momo Morikawa, Yosuke Tanaka, Michael E Shy, Stephan Zuchner, Nobutaka Hirokawa
Publikováno v:
EMBO J
The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors facilitates intramolecular interaction cycles between the kinesin motor and neck domains, which are essential for microtubule‐based motility. Here, we c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7b390e40ac1c4c6aa757113845aa70
https://europepmc.org/articles/PMC8886545/
https://europepmc.org/articles/PMC8886545/
Autor:
Yuansong Wan1, Momo Morikawa1,2, Manatsu Morikawa1, Suguru Iwata1,2, Naseer, Muhammad Imran3, Chaudhary, Adeel Gulzar Ahmed3, Yosuke Tanaka1, Nobutaka Hirokawa1 hirokawa@m.u-tokyo.ac.jp
Publikováno v:
Journal of Cell Biology. 2/6/2023, Vol. 222 Issue 2, p1-24. 31p.
Publikováno v:
Science Advances
Neuronal activity–dependent dampening and regeneration of dendritic KIF17 transport underlie cognitive flexibility.
Synaptic weight changes among postsynaptic densities within a single dendrite are regulated by the balance between localized pr
Synaptic weight changes among postsynaptic densities within a single dendrite are regulated by the balance between localized pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef21eb8a2d805c63829185fe6774ee3
https://pubmed.ncbi.nlm.nih.gov/33328231
https://pubmed.ncbi.nlm.nih.gov/33328231
Autor:
Manabu Toyoshima, Tadayuki Ogawa, Sotaro Ichinose, Xuguang Jiang, Takeo Yoshikawa, Akiyoshi Kakita, Shogo Yoshihara, Nobutaka Hirokawa, Yosuke Tanaka, Momo Morikawa, Hirooki Yabe, Yasuto Kunii
Publikováno v:
SSRN Electronic Journal.
Neurons in schizophrenia (SCZ) brains tend to undergo gross morphological changes, but its molecular mechanism is still largely elusive. Using Kif3b+/- mice as a SCZ model, here we show that high betaine diet can significantly remedy their schizophre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2cb11b88b607668454cd6ab352e836
https://doi.org/10.2139/ssrn.3624389
https://doi.org/10.2139/ssrn.3624389
Autor:
Hideyuki Okano, Hisako Ohba, Tomonori Hara, Chie Shimamoto-Mitsuyama, Yui Murata, Yoshimi Iwayama, Yayoi Nozaki, Yuka Kimura, Hideo Kimura, Kazuhiko Uchida, Akiko Watanabe, Takeo Yoshikawa, Kenji Hashimoto, Yosuke Tanaka, Norihiro Shibuya, Hirooki Yabe, Momo Morikawa, Kohji Meno, Motoko Maekawa, Tetsuo Ohnishi, Yasuko Hisano, Shabeesh Balan, Kazuya Iwamoto, Tomoko Toyota, Nobutaka Hirokawa, Brian Dean, Akiyoshi Kakita, Tadafumi Kato, Masayuki Ide, Takuya Katagiri, Takashi Ishii, Masanari Itokawa, Shigeyoshi Fujisawa, Manabu Toyoshima, Yasuto Kunii, Akinori Nishi, Yuina Wada
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
EMBO Molecular Medicine
EMBO Molecular Medicine
Schizophrenia is a complex, multifactorial disease that displays heterogeneous behavioral and cognitive syndrome (Lieberman & First, 2018). The origin of schizophrenia appears to lie in genetic and/or environmental disruption of brain development (Ow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af69ce2f17a070f3c0b71c3c438ebb2
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4
https://doaj.org/article/7d421ed9c97e4545be1c2101a84acaa4