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Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial

Autor: Monti, Giacomo, Bradic, Nikola, Marzaroli, Matteo, Konkayev, Aidos, Fominskiy, Evgeny, Kotani, Yuki, Likhvantsev, Valery V, Momesso, Elena, Nogtev, Pavel, Lobreglio, Rosetta, Redkin, Ivan, Toffoletto, Fabio, Bruni, Andrea, Baiardo Redaelli, Martina, D'Andrea, Natascia, Paternoster, Gianluca, Scandroglio, Anna Mara, Gallicchio, Francesca, Ballestra, Mariano, Calabrò, Maria Grazia, Cotoia, Antonella, Perone, Romina, Cuffaro, Raffaele, Montrucchio, Giorgia, Pota, Vincenzo, Ananiadou, Sofia, Lembo, Rosalba, Musu, Mario, Rauch, Simon, Galbiati, Carola, Pinelli, Fulvio, Pasin, Laura, Guarracino, Fabio, Santarpino, Giuseppe, Agrò, Felice Eugenio, Bove, Tiziana, Corradi, Francesco, Forfori, Francesco, Longhini, Federico, Cecconi, Maurizio, Landoni, Giovanni, Bellomo, Rinaldo, Zangrillo, Alberto

Importance: Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3977::007abbc7149a9007c8ad370bae459feb
https://hdl.handle.net/11591/500888

Continuous infusion versus intermittent administration of meropenem in critically ill patients (MERCY): A multicenter randomized double-blind trial. Rationale and design

Autor: Ingrid Marcela Pabon, Barbara Azzali, Mattia Bozzetti, Vincenzo Pota, Antonio De Sio, Andrey Yavorovskiy, Natascia D'Andrea, Rosetta Lobreglio, Andrea Della Selva, Evgeny Fominskiy, Federico Canavosio, Barbara Ferrara, Vittorio Pazzanese, Francesca Gallicchio, Nicola Pasculli, Valery Likhvantsev, Eugenio Garofalo, Sergio Colombo, Anna Mara Scandroglio, Felice Eugenio Agrò, Margherita Tozzi, Gianluca Paternoster, Francesco Corradi, Tiziana Bove, Filippo Palmesino, Elena Momesso, Luigi Vetrugno, Francesco Giuseppe Nisi, Giorgia Montrucchio, Daniela Missio, Mara Bernasconi, Giacomo Monti, Mariano Ballestra, Marco Gemma, Giovanni Marino, Silvia Ajello, Alberto Zangrillo, Rosalba Lembo, Maria Grazia Calabrò, Romina Perone, Andrea Bruni, Pavel Nogtev, Alberto Cappelletti, Gabriele Finco, Daniele Cristadoro, Leonarda Pia Cantatore, Marina Pieri, Sofia Ananiadou, Italo Calamai, Chiara Millin, A. Mattei, Luca Cabrini, Marina Petrova, Valentina Paola Plumari, Nicoletta Boffa, Davide Maraggia, Elena Moizo, Gianna Curci, Giovanni Landoni, Giuseppe Biondi-Zoccai, Giuseppe Giardina, Giacomo Iapichino, Carola Galbiati, Fabio Guarracino, Antonella Cotoia, Matteo Marzaroli, Nikola Bradic, Umberto Benedetto, Giorgio Gallioli, Fabrizio D'Ascenzo, Francesco Forfori, Fabio Toffoletto, Milena Mucci, Manuela Mainetti

Objective Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial activity against gram-negative, gram-positive and anaerobic micro-organisms and is important in the empirical treatment of serious infections in Intensive Care Unit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d072490aa836c3dc730522460e6e6e5
http://hdl.handle.net/11390/1206486

Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial.

Autor: Monti G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Bradic N; Clinical Department of Anesthesiology, Resuscitation and Intensive Medicine, University Hospital Dubrava, Zagreb, Croatia.; University North, Varazdin, Croatia., Marzaroli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Konkayev A; National Scientific Center of Traumatology and Orthopedia named acad NBatpenov, Astana Medical University, Astana, Kazakhstan., Fominskiy E; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kotani Y; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.; Kameda Medical Center, Kamogawa, Japan., Likhvantsev VV; V. Negovsky Reanimatology Research Institute, Moscow, Russia., Momesso E; UOC Anestesia Rianimazione Ospedale San Donà di Piave, San Donà di Piave, Italy., Nogtev P; I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia., Lobreglio R; Department of Anesthesia, Intensive Care and Emergency, Citta della Salute e della Scienza University Hospital, Turin, Italy., Redkin I; Federal Research and Clinical Center of Resuscitation and Rehabilitation, Moscow, Russia., Toffoletto F; UOC Anestesia Rianimazione Ospedale San Donà di Piave, San Donà di Piave, Italy., Bruni A; Anesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Baiardo Redaelli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., D'Andrea N; Department of Anesthesia and Intensive Care Medicine, ASUFC University Hospital of Udine, Udine, Italy., Paternoster G; Azienda Ospedaliera Regionale San Carlo, Potenza, Italy., Scandroglio AM; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Gallicchio F; Azienda Ospedaliera Regionale San Carlo, Potenza, Italy., Ballestra M; Rianimazione Ospedali Galliera, Genova, Italy., Calabrò MG; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Cotoia A; University Hospital Policlinico of Foggia, Foggia, Italy., Perone R; Department of Cardio Thoracic and Vascular Surgery, Pineta Grande Hospital, Pineta Grande, Italy., Cuffaro R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Montrucchio G; Department of Anesthesia, Intensive Care and Emergency, Citta della Salute e della Scienza University Hospital, Turin, Italy.; Department of Surgical Sciences, University of Turin, Turin, Italy., Pota V; Università della Campania L. Vanvitelli, Napoli, Italy., Ananiadou S; Anestesia e Rianimazione ASST Cremona, Cremona, Italy., Lembo R; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Musu M; Dipartimento di Scienze Mediche e Sanità Pubblica, Università degli Studi di Cagliari, Cagliari, Italy.; Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy., Rauch S; Department of Anaesthesiology and Intensive Care Medicine, Hospital of Merano, Merano, Italy., Galbiati C; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy., Pinelli F; Azienda Ospedaliera Universitaria Careggi, Florence, Italy., Pasin L; Azienda Ospedale Università Padova, Padua, Italy., Guarracino F; Dipartimento Anestesia e Rianimazione, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy., Santarpino G; Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.; GVM Care and Research, Department of Cardiac Surgery, Città di Lecce Hospital, Lecce, Italy.; Department of Cardiac Surgery, Paracelsus Medical University, Nuremberg, Germany., Agrò FE; Research Unit of Anesthesia and Intensive Care, Department of Medicine and Surgery, Università Campus Bio-Medico, Rome, Italy.; Operative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy., Bove T; Department of Anesthesia and Intensive Care Medicine, ASUFC University Hospital of Udine, Udine, Italy.; Department of Medicine, University of Udine, Udine, Italy., Corradi F; Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy., Forfori F; Department of Surgical, Medical, Molecular Pathology, and Critical Care Medicine, University of Pisa, Pisa, Italy., Longhini F; Anesthesia and Intensive Care, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Cecconi M; Department of Biomedical Sciences, Humanitas University Pieve Emanuele, Milan, Italy.; Department of Anaesthesia and Intensive Care, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Landoni G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Bellomo R; Department of Critical Care, University of Melbourne, Melbourne, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia., Zangrillo A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.

Publikováno v: JAMA [JAMA] 2023 Jul 11; Vol. 330 (2), pp. 141-151.