Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Molykutty J"'
Autor:
Molykutty J. Aryankalayil, Haaris Patel, Jared M. May, Uma Shankavaram, Michelle A. Bylicky, Shannon Martello, Sunita Chopra, Jim Axtelle, Naresh Menon, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Radiation injury, either from radiotherapy or a mass-casualty event requires a health care system that can efficiently allocate resources to patients. We conducted a comprehensive transcriptome analysis of whole blood from a nonhuman primate
Externí odkaz:
https://doaj.org/article/6fa9f0e4d23f495d8d84d8c179897a44
Autor:
Molykutty J. Aryankalayil, Michelle A. Bylicky, Shannon Martello, Sunita Chopra, Mary Sproull, Jared M. May, Aman Shankardass, Laurel MacMillan, Claire Vanpouille-Box, Juan Dalo, Kevin M. K. Scott, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Radiation injury from medical, accidental, or intentional sources can induce acute and long-term hepatic dysregulation, fibrosis, and cancer. This long-term hepatic dysregulation decreases quality of life and may lead to death. Our goal in t
Externí odkaz:
https://doaj.org/article/f2be66923f7043409c1e34cc8c6aacac
Autor:
Sunita Chopra, Uma Shankavaram, Michelle Bylicky, Juan Dalo, Kevin Scott, Molykutty J. Aryankalayil, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Recent and past research have highlighted the importance of the endothelium in the manifestation of radiation injury. Our primary focus is on medical triage and management following whole body or partial-body irradiation. Here we investigate
Externí odkaz:
https://doaj.org/article/0a71d507171040baaba5035ef44aef56
Autor:
Jared M. May, Uma Shankavaram, Michelle A. Bylicky, Sunita Chopra, Kevin Scott, Shannon Martello, Karla Thrall, Jim Axtelle, Naresh Menon, C. Norman Coleman, Molykutty J. Aryankalayil
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract In a mass radiation exposure, the healthcare system may rely on differential expression of miRNA to determine exposure and effectively allocate resources. To this end, miRNome analysis was performed on non-human primate serum after whole tho
Externí odkaz:
https://doaj.org/article/3d867539d00642e08915a7ae9623bf71
Autor:
Iris Eke, Molykutty J. Aryankalayil, Michelle A. Bylicky, Adeola Y. Makinde, Lance Liotta, Valerie Calvert, Emanuel F. Petricoin, Edward E. Graves, C. Norman Coleman
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The efficacy of molecular targeted therapy depends on expression and enzymatic activity of the target molecules. As radiotherapy modulates gene expression and protein phosphorylation dependent on dose and fractionation, we analyzed the long-
Externí odkaz:
https://doaj.org/article/20a423698d62445f83dc56265757f442
Autor:
Molykutty J. Aryankalayil, Shannon Martello, Michelle A. Bylicky, Sunita Chopra, Jared M. May, Aman Shankardass, Laurel MacMillan, Landy Sun, Jaleal Sanjak, Claire Vanpouille-Box, Iris Eke, C. Norman Coleman
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background Radiation therapy is integral to effective thoracic cancer treatments, but its application is limited by sensitivity of critical organs such as the heart. The impacts of acute radiation-induced damage and its chronic effects on no
Externí odkaz:
https://doaj.org/article/63b6648b6e304baaad201a8aeb009217
Autor:
Sunita Chopra, Maria Moroni, Jaleal Sanjak, Laurel MacMillan, Bernadette Hritzo, Shannon Martello, Michelle Bylicky, Jared May, C. Norman Coleman, Molykutty J. Aryankalayil
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents. We examined the whole blood gen
Externí odkaz:
https://doaj.org/article/a2516ae3c6894857babcede544e3384f
Autor:
Iris Eke, Michelle A. Bylicky, Veit Sandfort, Sunita Chopra, Shannon Martello, Edward E. Graves, C. Norman Coleman, Molykutty J. Aryankalayil
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 175-187 (2021)
Long non-coding RNAs (lncRNAs) have been shown to impact important biological functions such as proliferation, survival, and genomic stability. To analyze radiation-induced lncRNA expression in human tumors, we irradiated prostate cancer cells with a
Externí odkaz:
https://doaj.org/article/26b93631086d4fc78d670b89c64837ea
Autor:
Claire Vanpouille-Box, Amandine Alard, Molykutty J. Aryankalayil, Yasmeen Sarfraz, Julie M. Diamond, Robert J. Schneider, Giorgio Inghirami, C. Norman Coleman, Silvia C. Formenti, Sandra Demaria
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Trex1 is an exonuclease that degrades cytosolic DNA and has been associated with modulation of interferon responses in autoimmunity and viral infections. Here, the authors show that Trex1 attenuates the immunogenicity of cancer cells treated with hig
Externí odkaz:
https://doaj.org/article/fbe7810370734d60b0bb36cf8cb9767e
Autor:
Aryankalayil, Molykutty J.1 (AUTHOR) aryankalayilm@mail.nih.gov, Bylicky, Michelle A.1 (AUTHOR), Martello, Shannon1 (AUTHOR), Chopra, Sunita1 (AUTHOR), Sproull, Mary1 (AUTHOR), May, Jared M.1 (AUTHOR), Shankardass, Aman1 (AUTHOR), MacMillan, Laurel2 (AUTHOR), Vanpouille-Box, Claire3 (AUTHOR), Eke, Iris1,4 (AUTHOR), Scott, Kevin M. K.1 (AUTHOR), Dalo, Juan1 (AUTHOR), Coleman, C. Norman1,5 (AUTHOR)
Publikováno v:
International Journal of Radiation Biology. 2023, Vol. 99 Issue 11, p1702-1715. 14p.