(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

Autor: Lammertsma Adriaan A, Huisman Marc C, Windhorst Albert D, Molthoff Carla FM, Luurtsema Gert, Syvänen Stina, Voskuyl Rob A, de Lange Elizabeth C

Publikováno v: BMC Medical Imaging, Vol 11, Iss 1, p 1 (2011)

Abstract Background Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by

Externí odkaz: https://doaj.org/article/22533da4a69941199c7c9f678e2488e8

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography

Autor: Lammertsma Adriaan A, Molthoff Carla FM, Lubberink Mark, Duijst Suzanne, Boontje Nicky M, Vlasblom Ronald, Huisman Marc C, van den Brom Charissa E, van der Velden Jolanda, Boer Christa, Ouwens D Margriet, Diamant Michaela

Publikováno v: Cardiovascular Diabetology, Vol 8, Iss 1, p 39 (2009)

Abstract Background In vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose of the present study was to study in a rat model of early DCM, in v

Externí odkaz: https://doaj.org/article/d2412141b3104594b67d183dd822ab60

Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles.

Autor: Turaihi, Alexander H., Serné, Erik H., Molthoff, Carla F. M., Koning, Jasper J., Knol, Jaco, Niessen, Hans W., Goumans, Marie Jose T. H., van Poelgeest, Erik M., Yudkin, John S., Smulders, Yvo M., Jimenez, Connie R., van Hinsbergh, Victor W. M., Eringa, Etto C., Molthoff, Carla Fm, Jose Th Goumans, Marie, van Hinsbergh, Victor Wm

Publikováno v: Diabetes; Apr2020, Vol. 69 Issue 4, p603-613, 11p

[11C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein.

Autor: Froklage FE; Division of Pharmacology, LACDR, Leiden University, PO Box 9502, Leiden, 2300 RA, The Netherlands. s.syvanen@lacdr.leidenuniv.nl., Syvänen S, Hendrikse NH, Huisman MC, Molthoff CF, Tagawa Y, Reijneveld JC, Heimans JJ, Lammertsma AA, Eriksson J, de Lange EC, Voskuyl RA

Publikováno v: EJNMMI research [EJNMMI Res] 2012 Mar 28; Vol. 2, pp. 12. Date of Electronic Publication: 2012 Mar 28.