Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Molodavkin Gm"'
Autor:
Molodavkin Gm, V. P. Lezina, V. I. Poseva, G. V. Mokrov, T. A. Voronina, A. M. Likhosherstov, T. A. Gudasheva
Publikováno v:
Pharmaceutical Chemistry Journal. 47:464-469
A series of new 1,2,4,5-tetrahydro-3H-pyrrolo[1,2-a][1,4]diazepin-3-one derivatives were synthesized from widely available furfurol, 3-aminopropionic acid, and amines. The antidepressant and anxiolytic properties of the obtained compounds were invest
Antidepressant Effect of Dimeric Dipeptide GSB-106, an Original Low-Molecular-Weight Mimetic of BDNF
Autor:
T. A. Voronina, T. A. Gudasheva, Sergey B. Seredenin, Molodavkin Gm, S. A. Litvinova, V. I. Poseva, E A Elizarova, T. L. Garibova
Publikováno v:
Acta Naturae
A large amount of clinical and experimental data suggest the involvement of neurotrophins, in particular the brain-derived neurotrophic factor (BDNF), in depression pathogenesis. However, the therapeutic use of BDNF is limited because of its instabil
Publikováno v:
Pharmaceutical Chemistry Journal. 46:15-19
The synthesis of compounds effective in the treatment of anxiety—depression disorders is described. It is established that 4,6-dimethyl-2-(4-chlorophenyl)-2,3-dihydro-1H-pyrazolo[4,3-c]pyridine-3-one hydrochloride (IVa) possesses combined antidepre
Autor:
O. I. Epshtein, Molodavkin Gm, V. I. Poseva, M. A. Putilovskii, V. V. Andreeva, I. A. Ertuzun, Yu. L. Dugina, N. I. Suslov, N. N. Yakovleva, T. A. Voronina
Publikováno v:
Bulletin of experimental biology and medicine. 159(6)
The anxiolytic and antidepressant activities of complex preparations divaza and brizantin containing antibodies to brain-specific protein S100 were estimated using Vogel conflict test and Nomura forced swimming test. Course treatment (5 days) of briz
Publikováno v:
Bulletin of Experimental Biology and Medicine. 148:54-56
Antidepressant activity of Russian product Azafen (pipofezine) and foreign products Paroxetine and Tianepine was compared using behavioral despair test (Porsolt test) and forced swimming test in a container with wheels (Nomura). Azafen signifi cantly
Publikováno v:
Bulletin of Experimental Biology and Medicine. :14-16
Phenazepam in ultralow doses produced an anxiolytic effect on male outbred albino rats in the conflict situation and elevated plus-maze models and inhibited q-activity in EEG, which is typical of tranquilizers. As differentiated from standard doses,
Autor:
Molodavkin Gm, N. I. Khorseva, Sergey B. Seredenin, L. I. Chernyavskaya, E. B. Burlakova, T. A. Voronina
Publikováno v:
Bulletin of Experimental Biology and Medicine. :39-41
Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10-9-10-15 mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myore
Publikováno v:
Pharmaceutical Chemistry Journal. 35:591-593
Publikováno v:
ChemInform. 33
Publikováno v:
Pharmaceutical Chemistry Journal. 32:207-209