Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Molly Z Karlinsey"'
Autor:
Brandon G Santiago, Stephen H Eisennagel, Gregory E Peckham, Amanda M Liebhardt, Chad L Alburn, Theresa J Roethke, Michael A Reilly, Jens R Sydor, Molly Z Karlinsey
Publikováno v:
Bioanalysis. 15:177-191
As the desire for a shortened design/make/test/learn cycle increases in early drug discovery, the pressure to rapidly deliver drug metabolism pharmacokinetic data continues to rise. From a bioanalytical standpoint, in vitro assays are challenging bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8e751797d6b6f729953d29d28319b9
https://doi.org/10.4155/bio-2022-0207
https://doi.org/10.4155/bio-2022-0207
Autor:
Yinghe Brenda Li, Andrew P Mayer, John F. Kellie, Caroline J. Sychterz, Kristen E. Pannullo, Matthew Szapacs, Kristy J Fraley, Molly Z Karlinsey
Publikováno v:
Analytical chemistry. 92(12)
Complex biotherapeutics present challenges from drug discovery, screening, and development perspectives. While monoclonal antibody drugs are not monitored for metabolites in the same manner as small molecules, biotherapeutics such as fusion proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f91aeddf3229daeca008484cb53b7c8
https://pubmed.ncbi.nlm.nih.gov/32392410
https://pubmed.ncbi.nlm.nih.gov/32392410
Publikováno v:
Analytical Methods. 8:3023-3033
Carbohydrate analysis poses many analytical challenges, in terms of extraction, chromatographic separation, and detection. Extraction challenges are associated with poor recovery from biological matrices using conventional techniques such as protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50335eaee4d0fab9fc65f53f7c97371d
https://doi.org/10.1039/c6ay00061d
https://doi.org/10.1039/c6ay00061d
Autor:
Molly Z Karlinsey, John F. Kellie
Publikováno v:
Bioanalysis.
Biotherapeutic drugs have emerged in quantity in pharmaceutical pipelines, and increasingly diverse biomolecules are progressed through preclinical and clinical development. As purification, separation, mass spectrometer detection and data processing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16930baffeef373d6d1bcd66a074d85
https://pubmed.ncbi.nlm.nih.gov/30325207
https://pubmed.ncbi.nlm.nih.gov/30325207
Autor:
Shing H. Mai, Sarah L. Childs, Robert A. Biddlecombe, Molly Z Karlinsey, John R. White, John F. Kellie, Shugui Chen, Andrew S. Thomson
Publikováno v:
Journal of pharmaceutical sciences. 108(4)
Biotransformation monitoring involves tracking drug modification occurring during in-life studies. Critical Quality Attribute monitoring from forced degraded drug material or in-life sample sets can provide an in-depth assessment of product quality f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561a1ec778a67ced99f54cedfabeba7d
https://pubmed.ncbi.nlm.nih.gov/30465782
https://pubmed.ncbi.nlm.nih.gov/30465782
Publikováno v:
Bioanalysis. 10(4)
Aim: GSKA is a compound that was in development in clinical trials. A bioanalysis method to quantify GSKA using volumetric absorptive microsampling (VAMS) was developed and hematocrit (HCT) related assay bias was investigated. Methodology: After accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08086a6b2721a1dfb319dc642f0df4dc
https://pubmed.ncbi.nlm.nih.gov/29333871
https://pubmed.ncbi.nlm.nih.gov/29333871
Publikováno v:
Bioanalysis. 9(23)
Aim: Typically, quantitation of biotherapeutics from biological matrices by LC–MS is based on a surrogate peptide approach to determine molecule concentration. Recent efforts have focused on quantitation of the intact protein molecules or larger ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c2580edde804fb4c10d046c4c92616
https://pubmed.ncbi.nlm.nih.gov/29171758
https://pubmed.ncbi.nlm.nih.gov/29171758
Autor:
Michael S. Forbes, Timothy L. Macdonald, Preeti Chhabra, Lisa A. Palmer, Victor E. Laubach, Allan Doctor, Benjamin Gaston, Molly Z. Karlinsey, Mary Lynn Sheram
Publikováno v:
Journal of Clinical Investigation. 117:2592-2601
NO transfer reactions between protein and peptide cysteines have been proposed to represent regulated signaling processes. We used the pharmaceutical antioxidant N-acetylcysteine (NAC) as a bait reactant to measure NO transfer reactions in blood and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdbcc2da4985939423b0310c0c2728ab
https://doi.org/10.1172/jci29444
https://doi.org/10.1172/jci29444
Autor:
Esaie Pierre, Christopher A. Evans, Chester L. Bowen, Hermes Licea-Perez, Alan H. Stokes, Joseph Siple, Kristen E Jurusik, Molly Z Karlinsey, Neil Spooner, Jim Kenney
Publikováno v:
Bioanalysis. 5(9)
Background: A novel device and procedure for the collection and isolation of microvolumes of plasma have been developed and two pilot rodent PK studies have been completed. Results: This method involves collection of blood into a plastic-wrapped, EDT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743e5f0bc1b20e417bab27c89c6aeb5f
https://pubmed.ncbi.nlm.nih.gov/23641701
https://pubmed.ncbi.nlm.nih.gov/23641701