Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Molly Weaver"'
Autor:
Alessandra M. Sullivan, Andrej A. Arsovski, Agnieszka Thompson, Richard Sandstrom, Robert E. Thurman, Shane Neph, Audra K. Johnson, Shawn T. Sullivan, Peter J. Sabo, Fidencio V. Neri, Molly Weaver, Morgan Diegel, Jennifer L. Nemhauser, John A. Stamatoyannopoulos, Kerry L. Bubb, Christine Queitsch
Publikováno v:
Frontiers in Plant Science, Vol 10 (2019)
The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors. The accessibility and critical functions of epidermal cells have made them a model for connecti
Externí odkaz:
https://doaj.org/article/5c5ed775427e413b932d14ba9f620d34
Autor:
Mingju Cao, James W. MacDonald, Hai L. Liu, Molly Weaver, Marina Cortes, Lucien D. Durosier, Patrick Burns, Gilles Fecteau, André Desrochers, Jay Schulkin, Marta C. Antonelli, Raphael A. Bernier, Michael Dorschner, Theo K. Bammler, Martin G. Frasch
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential
Externí odkaz:
https://doaj.org/article/e140bb9426c84172bbaf67725170ec66
Autor:
Alessandra M. Sullivan, Andrej A. Arsovski, Janne Lempe, Kerry L. Bubb, Matthew T. Weirauch, Peter J. Sabo, Richard Sandstrom, Robert E. Thurman, Shane Neph, Alex P. Reynolds, Andrew B. Stergachis, Benjamin Vernot, Audra K. Johnson, Eric Haugen, Shawn T. Sullivan, Agnieszka Thompson, Fidencio V. Neri III, Molly Weaver, Morgan Diegel, Sanie Mnaimneh, Ally Yang, Timothy R. Hughes, Jennifer L. Nemhauser, Christine Queitsch, John A. Stamatoyannopoulos
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 2015-2030 (2014)
Our understanding of gene regulation in plants is constrained by our limited knowledge of plant cis-regulatory DNA and its dynamics. We mapped DNase I hypersensitive sites (DHSs) in A. thaliana seedlings and used genomic footprinting to delineate ∼
Externí odkaz:
https://doaj.org/article/eb2965a5058047bd8d6435cb1f0f6504
Autor:
Mingju Cao, James W. MacDonald, Hai L. Liu, Molly Weaver, Marina Cortes, Lucien D. Durosier, Patrick Burns, Gilles Fecteau, André Desrochers, Jay Schulkin, Marta C. Antonelli, Raphael A. Bernier, Michael Dorschner, Theo K. Bammler, Martin G. Frasch
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e65366d98234e3a6abcaec15f73b204
http://arxiv.org/abs/1812.06617
http://arxiv.org/abs/1812.06617
Autor:
Agnieszka Thompson, Jennifer L. Nemhauser, Alessandra M. Sullivan, Andrej A Arsovski, Molly Weaver, Shawn Sullivan, John A. Stamatoyannopoulos, Pete J. Sabo, Audra K. Johnson, Kerry L. Bubb, Richard Sandstrom, Fidencio Neri, Christine Queitsch, Robert E. Thurman, Shane Neph, Morgan Diegel
The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors. The accessibility and critical functions of epidermal cells have made them a model for connecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ece7922c9189297969f28661bd2cc8
Autor:
Rodriguez-Casero, Sophie Calvert, Ingrid E. Scheffer, Michael O. Dorschner, Sara Kivity, Simone C. Yendle, N. Zelnick, Dorit Lev, Jay Shendure, Samuel F. Berkovic, Sinéad Heavin, Steensbjerre R. Møller, Geoffrey Wallace, Ann M. E. Bye, Rachel L. Webster, Heather C Mefford, Molly Weaver, Katherine B. Howell, Stephen M. Malone, Thorsten Stanley, Brian J. O'Roak, Jeremy L. Freeman, Lynette G. Sadleir, Joseph Cook, Carvill Gl, Tally Lerman-Sagie, Andrew Bleasel, Mark T Mackay, Danielle M. Andrade, Amos D. Korczyn, Asma A. Khan
Publikováno v:
Epilepsia. 54:4-29
Purpose: Epileptic encephalopathies (EEs) are a devastating group of epilepsies characterized by refractory seizures, cognitive arrest or regression, associated with ongoing epileptic activity, and a poor prognosis. De novo mutations in a number of g
Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1
Autor:
Zaid Afawi, Sophie Calvert, Heather C Mefford, Adiba Khan, Geoffrey Wallace, Deepak Gill, Dorit Lev, Nathanel Zelnick, Brian J. O'Roak, Ann M. E. Bye, Molly Weaver, Lynette G. Sadleir, Andrew Bleasel, Victoria Rodriguez-Casero, Mark T Mackay, Joseph Cook, Sara Kivity, Thorsten Stanley, Stephen M. Malone, Ingrid E. Scheffer, Simone C. Yendle, Jacinta M McMahon, Richard Webster, Tally Lerman-Sagie, Katherine B. Howell, Jay Shendure, Gemma L. Carvill, Samuel F. Berkovic, Jeremy L. Freeman, Danielle M. Andrade, Amos D. Korczyn, Rikke S. Møller, Sinéad Heavin, Michael O. Dorschner
Publikováno v:
Nature genetics
Carvill, G L, Heavin, S B, Yendle, S C, McMahon, J M, O'Roak, B J, Cook, J, Khan, A, Dorschner, M O, Weaver, M, Calvert, S, Malone, S, Wallace, G, Stanley, T, Bye, A M E, Bleasel, A, Howell, K B, Kivity, S, Mackay, M T, Rodriguez-Casero, V, Webster, R, Korczyn, A, Afawi, Z, Zelnick, N, Lerman-Sagie, T, Lev, D, Møller, R S, Gill, D, Andrade, D M, Freeman, J L, Sadleir, L G, Shendure, J, Berkovic, S F, Scheffer, I E & Mefford, H C 2013, ' Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 ', Nature Genetics, vol. 45, no. 7, pp. 825-830 . https://doi.org/10.1038/ng.2646
Carvill, G L, Heavin, S B, Yendle, S C, McMahon, J M, O'Roak, B J, Cook, J, Khan, A, Dorschner, M O, Weaver, M, Calvert, S, Malone, S, Wallace, G, Stanley, T, Bye, A M E, Bleasel, A, Howell, K B, Kivity, S, Mackay, M T, Rodriguez-Casero, V, Webster, R, Korczyn, A, Afawi, Z, Zelnick, N, Lerman-Sagie, T, Lev, D, Møller, R S, Gill, D, Andrade, D M, Freeman, J L, Sadleir, L G, Shendure, J, Berkovic, S F, Scheffer, I E & Mefford, H C 2013, ' Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1 ', Nature Genetics, vol. 45, no. 7, pp. 825-830 . https://doi.org/10.1038/ng.2646
Epileptic encephalopathies are a devastating group of epilepsies with poor prognosis, of which the majority are of unknown etiology. We perform targeted massively parallel resequencing of 19 known and 46 candidate genes for epileptic encephalopathy i
Autor:
Carleton Goold, Nadia Solovieff, William B. Dobyns, Richard A. Gibbs, Elisa Rahikkala, Jonathan D. Biag, Colleen F. Macmurdo, Eric Boerwinkle, Sonya A. Gunter, Sandra L. Poliachik, Brian H.Y. Chung, Christine D. Wilson, Evan A. Boyle, Scott Mahan, Robert F. Hevner, Russell P. Saneto, Katta M. Girisha, Rebecca Leary, Wendy Winckler, Molly Weaver, Sharon S. McDaniel, Jay Shendure, Laura A. Jansen, Shanming Liu, Shalini N. Jhangiani, Andrew E. Timms, William R. Sellers, Gisele Ishak, Michael Morrissey, Michael O. Dorschner, Donna M. Muzny, Catarina D. Campbell, Jeffrey G. Ojemann, Beth Martin, Edward J. Novotny, Renzo Guerrini, Ghayda M. Mirzaa, Leon Murphy, Valerio Conti, Jonathan A. Bernstein, James R. Lupski, Sarah Collins, Suchithra Menon, Carissa Olds, Kit San Yeung
Publikováno v:
JAMA neurology. 73(7)
Importance Focal cortical dysplasia (FCD), hemimegalencephaly, and megalencephaly constitute a spectrum of malformations of cortical development with shared neuropathologic features. These disorders are associated with significant childhood morbidity
Autor:
Vishwanath R. Iyer, Lingyun Song, Michael O. Dorschner, Joshua M. Akey, Andrew B. Stergachis, Kristen Lee, Anthony Shafer, Shinny Vong, Amartya Sanyal, Hongzhu Qu, Audra K. Johnson, Ericka M. Johnson, Kavita Garg, Minerva E. Sanchez, Daniel Bates, Benjamin Vernot, George Stamatoyannopoulos, Tanya Kutyavin, Robert E. Thurman, Patrick A. Navas, Douglas Dunn, Eric Rynes, Bryan R. Lajoie, Matthew T. Maurano, Jeff Vierstra, Molly Weaver, Jason D. Lieb, Sam John, Alexias Safi, Lisa Boatman, Shane Neph, Zhancheng Zhang, Yongqi Yan, Bum Kyu Lee, Dimitra Lotakis, Zhuzhu Zhang, Gregory E. Crawford, Tristan Frum, Abigail K. Ebersol, Richard Sandstrom, Theresa K. Canfield, Eric Haugen, Erika Giste, Job Dekker, Muneesh Tewari, Alex Reynolds, Eric D. Nguyen, Fidencio Neri, Richard Humbert, Peter J. Sabo, Morgan Diegel, John A. Stamatoyannopoulos, Vaughn Roach, Hao Wang, Rajinder Kaul, Terrence S. Furey, Nathan C. Sheffield, R. Scott Hansen, Jeremy M. Simon, Shamil R. Sunyaev, Boris Lenhard, Darin London
Publikováno v:
Nature
DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned the discovery of all classes of cis-regulatory elements including enhancers, promoters, insulators, silencers and locus control regions. Here we present the first
Autor:
Michael J. MacCoss, Mark Groudine, Molly Weaver, Tanya Kutyavin, John A. Stamatoyannopoulos, Shane Neph, Daniel Bates, Eric Rynes, Benjamin Vernot, Douglas Dunn, Anthony Schafer, Joshua M. Akey, Peter J. Sabo, Jeff Vierstra, Robert E. Thurman, R. Scott Hansen, Andrew B. Stergachis, Rajinder Kaul, Shinny Vong, Alex Reynolds, Theresa K. Canfield, Richard Humbert, Erika Giste, Jun Neri, Michaël Bender, Miaohua Zhang, Kristen Lee, Rachel Byron, Richard Sandstrom, Sam John, Eric Haugen, Gayathri Balasundaram, Vaughn Roach, Morgan Diegel, Hao Wang, Audra K. Johnson, Matthew T. Maurano
Publikováno v:
Nature
Regulatory factor binding to genomic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footprints. Using genomic DNase I footprinting across 41 diverse cell and tissue types, we detected 45 million transcrip