Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Molly S Hein"'
Autor:
Consuelo M López De Padilla, Molly S Hein, Cynthia S Crowson, Christopher S Choo, Abigail B Green, Michelle Petri, Hatice Bilgic, Emily C Baechler, Ann M Reed
Publikováno v:
SAGE Open Medicine, Vol 1 (2013)
Objective: We investigated ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif, member 13) messenger RNA levels as a biomarker of disease features in systemic lupus erythematosus. Methods: We measured and compared messen
Externí odkaz:
https://doaj.org/article/cdfc883bb7224367a4f9a213d2ba3da7
Autor:
Jennifer L Oliveira, Christineil H Thompson, Siva Arumugam Saravanaperumal, Tejaswi Koganti, Garrett Jenkinson, Molly S Hein, Mira A Kohorst, Linda Hasadsri, Phuong L Nguyen, Dietrich Matern, Benjamin R Kipp, Eric W Klee, Eric D Wieben, James D Hoyer, Aruna Rangan
Publikováno v:
Clinical Chemistry.
Background Large β-globin gene cluster deletions (hereditary persistence of fetal hemoglobin [Hb] or β-, δβ-, γδβ-, and ϵγδβ-thalassemia), are associated with widely disparate phenotypes, including variable degrees of microcytic anemia and
Autor:
J. Martin Johnston, Jennifer L. Oliveira, Michelle E. Savedra, Lea M. Coon, Min Shi, Rong He, Molly S. Hein, Aruna Rangan, James D. Hoyer, Benjamin R. Kipp, Nikita Mehta
Publikováno v:
Hemoglobin. 44:174-178
Hb Bronovo [α103(G10)His→Leu, HBA2: c.311A>T] is an α-globin variant that interferes with and decreases binding efficiency to α hemoglobin (Hb) stabilizing protein (AHSP), a chaperone molecule. The...
Autor:
Jennifer L. Oliveira, Andre M. Oliveira, Michelle E. Savedra, Rong He, Aruna Rangan, Linnea M. Baudhuin, James D. Hoyer, Tavanna R. Porter, Laura J. Train, Molly S. Hein, Phuong L. Nguyen, Lea M. Coon
Publikováno v:
Blood. 134:2228-2228
Background: Genetic variants resulting in quantitative defects in the production of α-spectrin are associated with autosomal recessive hereditary spherocytosis (HS). Because erythroid cells produce α-spectrin in a 3-4:1 ratio in relation to β-spec
Autor:
Jennifer L. Oliveira, Min Shi, James D. Hoyer, Molly S. Hein, Tavanna R. Porter, Aruna Rangan, Michelle E. Savedra, Phuong L. Nguyen, Jessica Szuberski
Publikováno v:
Blood. 134:1011-1011
Background: Voxelotor (GBT440) is a small molecule allosteric effector with high specificity for hemoglobin (Hb) that inhibits Hb S polymerization by increasing hemoglobin oxygen affinity. Developed as an oral, once-daily medication, it is undergoing
Autor:
James D. Hoyer, Christopher A. Hilker, Joseph H. Blommel, Jin Jen, Rong He, Aruna Rangan, Eric W. Klee, Tejaswi Koganti, Ross A. Aleff, David S. Viswanatha, William G. Jenkinson, Eric D. Wieben, Nicole L. Hoppman, Tavanna R. Porter, Molly S. Hein, Jennifer L. Oliveira, Benjamin R. Kipp
Publikováno v:
Blood. 134:3548-3548
Introduction: Globin gene sequencing has long been impeded by repetitive regions, homology and structural variation. Currently, long-read sequencing technology has been limited by high cost and error rate. These challenges can be mitigated by sample
Autor:
Mrinal M. Patnaik, Kenneth C. Swanson, Ayalew Tefferi, James D. Hoyer, Jennifer L. Oliveira, Stefan K.G. Grebe, Molly S. Hein, Michelle E. Savedra, Animesh Pardanani, Tavanna R. Porter, David S. Viswanatha, Lori Frederick, Lea M. Coon
Publikováno v:
American journal of hematology.
Hereditary erythrocytosis is associated with high oxygen affinity hemoglobin variants (HOAs), 2,3-bisphosphoglycerate deficiency and abnormalities in EPOR and the oxygen-sensing pathway proteins PHD, HIF2α, and VHL. Our laboratory has 40 years of ex
Autor:
Molly S. Hein, Ann M. Reed, Consuelo M. Lopez De Padilla, Floranne C. Ernste, Cynthia S. Crowson
Publikováno v:
The Journal of Rheumatology. 40:1200-1211
Objective:To determine the clinical characteristics and subsets of peripheral blood lymphocytes (PBL), which correlate with decreased disease activity in patients with juvenile dermatomyositis (JDM).Methods.Peripheral blood mononuclear cells from 24
Autor:
Steven R. Ytterberg, Cynthia S. Crowson, Kelly T. McNallan, Ann M. Reed, Erik J. Peterson, Shreyasee Amin, Molly S. Hein, Emily C. Baechler, Richard J. Bram, Hatice Bilgic, Consuelo M. Lopez De Padilla
Publikováno v:
The Journal of Rheumatology. 40:294-302
Objective.To investigate B cell survival cytokine messenger RNA (mRNA) levels as biomarkers of idiopathic inflammatory myopathies (IIM).Methods.We measured and compared mRNA levels of B cell survival cytokines by quantitative real-time polymerase cha
Autor:
Erik J. Peterson, Emily C. Baechler, Michael A. Strausbauch, Floranne C. Ernste, Timothy B. Niewold, Ann M. Reed, Richard S. Pendegraft, Cynthia S. Crowson, Molly S. Hein, Consuelo M. Lopez De Padilla
Publikováno v:
The Journal of rheumatology. 44(1)
Objective.To identify shared and differential molecular pathways in blood and affected muscle between adult dermatomyositis (DM) and juvenile DM, and their association with clinical disease activity measures.Methods.Gene expression of transcription f