Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Molly Rosano"'
Autor:
David P. Ryan, Eileen M. O'Reilly, Kenneth H. Yu, James M. Roach, Donald A. Richards, Spencer H. Shao, Julie Wolf, Tanios Bekaii-Saab, Diletta Barone, Keith T. Flaherty, Devalingam Mahalingam, Molly Rosano, Silva Krause
Publikováno v:
Eur J Cancer
Background Necuparanib, a rationally engineered low-molecular-weight heparin, combined with gemcitabine/nab-paclitaxel showed an encouraging safety and oncologic signal in a phase Ib trial. This randomised multicentre phase II trial evaluates the add
Autor:
Catherine Tjan, Keith T. Flaherty, James M. Roach, Silva Krause, Eileen M. O'Reilly, Paul J. E. Miller, Darrell Nix, Kenneth H. Yu, Molly Rosano, William Avery, David P. Ryan, Julie Wolf
Publikováno v:
The Oncologist
Lessons LearnedDespite the compelling preclinical rationale of evaluating the genetically engineered heparin derivative, necuparanib, combined with standard therapy in metastatic pancreas adenocarcinoma, the results were ultimately disappointing. Saf
Autor:
James M. Roach, Paul J. E. Miller, Eileen M. O'Reilly, Molly Rosano, David P. Ryan, Silva Krause, Louis Vaickus, William Avery, Tanios Bekaii-Saab, Keith T. Flaherty, Devalingam Mahalingam, Donald A. Richards, Spencer H. Shao, Julie Wolf
Publikováno v:
Journal of Clinical Oncology. 35:370-370
370 Background: The Phase 1 portion of a Phase 1/2 trial of Necuparanib (“Necu”) combined with nab-paclitaxel (nabP) + gemcitabine (gem) in patients with metastatic pancreatic cancer (ClinicalTrials.gov Identifier NCT01621243) showed acceptable s
Autor:
C. Huntenburg, B. Pavlova, D. Palmer, S. Darne, Niti Goel, J. Caminis, M. Alai-Safar, Tanmoy Ganguly, J. Hillson, D. Weilert, Jennifer Doralt, R. Reeve, P. Rhyne, James M. Roach, Molly Rosano, Tim Mant
Publikováno v:
Annals of the Rheumatic Diseases. 75:495.3-496
Background M923 is being developed as a biosimilar to the reference product HUMIRA® (adalimumab). An extensive panel of tests were used to characterize the physicochemical, functional, and in vivo attributes to support the initiation of clinical tes
Inhaled Cationic Airway Lining Modulator (iCALM) Attenuates Allergen-Induced Eosinophilic Bronchitis
Autor:
Laura Cancelliere, John P. Hanrahan, Molly Rosano, Katherine Radford, Shauna Denis, Parameswaran Nair
Publikováno v:
B34. INFLAMMATORY MECHANISMS IN ASTHMA.
Autor:
Paul J. E. Miller, Birgit Schultes, Eileen M. O'Reilly, James M. Roach, David P. Ryan, Molly Rosano, Julie Wolf, Keith T. Flaherty, Devalingam Mahalingam
Publikováno v:
Journal of Clinical Oncology. 33:4114-4114
4114 Background: Preclinical studies have shown necuparanib (necu)’s ability to bind growth factors, adhesion molecules, and chemokines to inhibit tumor progression, invasion, metastasis, and angio...