Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Molly M. Haskins"'
Publikováno v:
IUCrJ, Vol 10, Iss 3, Pp 329-340 (2023)
Hesperetin (HES) is a weakly acidic flavonoid of topical interest owing to its antiviral properties. Despite the presence of HES in many dietary supplements, its bioavailability is hindered by poor aqueous solubility (1.35 µg ml−1) and rapid first
Externí odkaz:
https://doaj.org/article/c4199a6be2c24571bdd0ba5e30cb0511
Publikováno v:
Crystal Growth & Design. 22:3333-3342
Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ioniz
Autor:
Shasha Jin, Molly M. Haskins, Yassin H. Andaloussi, Ruiling Ouyang, Junbo Gong, Michael J. Zaworotko
We report the existence of conformational polymorphism in an ionic cocrystal (ICC) of the nutraceutical compound hesperetin (HES) in which its tetraethylammonium (TEA+) salt serves as a coformer. Three polymorphs, HESTEA-α, HESTEA-β and HESTEA-γ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2e47b10f288a77a4d5af028767d990
Autor:
Chenghua Deng, Bai-Qiao Song, Matteo Lusi, Andrey A. Bezrukov, Molly M. Haskins, Mei-Yan Gao, Yun-Lei Peng, Jian-Gong Ma, Peng Cheng, Soumya Mukherjee, Michael J. Zaworotko
Chiral metal−organic materials (CMOMs), can offer molecular binding sites that mimic the enantioselectivity exhibited by biomolecules and are amenable to systematic fine-tuning of structure and properties. Herein, we report that the reaction of Ni(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bd38ca6109c7edf943d7c17b36d979
Autor:
Michael J. Zaworotko, Molly M. Haskins
Publikováno v:
Crystal Growth & Design
Cocrystals of biologically active molecular compounds have potential utility in drug products thanks to their effect upon physicochemical properties such as aqueous solubility. The fact that control of cocrystallization can be more challenging than c