Enriched environment enhances β‐adrenergic signaling to prevent microglia inflammation by amyloid‐β

Autor: Huixin Xu, Molly M Rajsombath, Pia Weikop, Dennis J Selkoe

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-17 (2018)

Abstract Environmental enrichment (EE) is a rodent behavioral paradigm that can model the cognitive benefits to humans associated with intellectual activity and exercise. We recently discovered EE's anti‐inflammatory protection of brain microglia a

Externí odkaz: https://doaj.org/article/6042a47b2d4743dcb10dfa26b12af8bc

Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice

Autor: Thomas D McCaffery, Silke Nuber, Warren D. Hirst, Alice Y Nam, Tim Moors, Dennis J. Selkoe, Andreas Weihofen, Kelly E. Glajch, Yi Chen, Ulf Dettmer, Molly M Rajsombath, Pascal A Bechade

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance The mechanisms responsible for brain α-synuclein (αS) dyshomeostasis, caused by Gaucher’s GBA1 mutations that increase Parkinson’s disease (PD) risk, are largely unknown. We previously showed that abrogating physiological αS tetra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fa12f9336821ebecf68270d274c6b0
https://pubmed.ncbi.nlm.nih.gov/34326260

Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice

Autor: Alice Y Nam, Molly M Rajsombath, Silke Nuber, Maria Ericsson

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(38)

Many studies report a higher risk for Parkinson's disease (PD) and younger age of onset in men. This, and the fact that the neuropathological process underlying PD symptoms may begin before menopause, suggests that estrogen-based hormone therapy coul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d047c0a50d4b71579c2490d31b8d3110
https://pubmed.ncbi.nlm.nih.gov/31405930

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers

Autor: Dennis J. Selkoe, Huixin Xu, Ting Yang, Shaomin Li, Molly M Rajsombath, Eilrayna Gelyana

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(35)

Microglial dysfunction is increasingly recognized as a key contributor to the pathogenesis of Alzheimer9s disease (AD). Environmental enrichment (EE) is well documented to enhance neuronal form and function, but almost nothing is known about whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd679bd0c7abece9ac7fb87de746df7
https://pubmed.ncbi.nlm.nih.gov/28100733

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Autor: Nuber S; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Rajsombath M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Minakaki G; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University (FAU), Erlangen-Nürnberg, 91054 Erlangen, Germany., Winkler J; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-University (FAU), Erlangen-Nürnberg, 91054 Erlangen, Germany., Müller CP; Department of Psychiatry and Psychotherapy, Friedrich-Alexander-University (FAU), Erlangen-Nürnberg, 91054 Erlangen, Germany., Ericsson M; Electron Microscopy Laboratory, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Caldarone B; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; NeuroBehavior Laboratory, Harvard NeuroDiscovery Center, Harvard Medical School, Boston, MA 02115, USA., Dettmer U; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA., Selkoe DJ; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: dselkoe@bwh.harvard.edu.

Publikováno v: Neuron [Neuron] 2018 Oct 10; Vol. 100 (1), pp. 75-90.e5.